@article {1737,
	title = {Systematic optimization of exhaustive electrokinetic injection combined with micellar sweeping in capillary electrophoresis},
	journal = {Analyst},
	volume = {132},
	number = {2},
	year = {2007},
	note = {Fang, Ning Meng, Pingjia Zhang, Hong Sun, Ying Chen, David D. Y.},
	pages = {127-134},
	abstract = {The combination of exhaustive electrokinetic injection and sweeping micellar electrokinetic chromatography (sweeping-MEKC) in capillary electrophoresis often provides a several thousandfold improvement in concentration detection limit. However, reproducibility of this method has been a major issue that often prevents its use as a quantitative tool for the analysis of ultra-trace analytes in complex matrices. In this paper, we demonstrate that such a technique can be systematically optimized with five key factors: the conductivity of the sample solution, the conductivities of the separation buffers, the fraction of the capillary that is filled with the high conductivity buffer, the electrokinetic injection time, and the surfactant concentration. By controlling the sample conductivity, we were able to achieve highly reproducible results, while still maintaining the sensitivity of field-amplified sample injection. At optimal conditions, we were able to analyze three amine drugs (amphetamine, methamphetamine, and methylenedioxymethamphetamine) with limits of detection of 6 to 8 pg ml(-1) (ppt), which is a several thousand-fold improvement over normal sample injection using CE with a photodiode array detector.},
	isbn = {0003-2654},
	url = {<Go to ISI>://000243789800008},
	author = {Fang, N. and Meng, P. J. and Zhang, H. and Ying, S. and Chen, D. D. Y.}
}
