@article {1480, title = {Electrospray ionization source geometry for mass spectrometry: past, present, and future}, journal = {Trac-Trends in Analytical Chemistry}, volume = {25}, number = {3}, year = {2006}, note = {ISI Document Delivery No.: 026CJTimes Cited: 34Cited Reference Count: 130}, month = {Mar}, pages = {243-256}, type = {Review}, abstract = {The geometry of an electrospray ion source plays important roles in the processes of analyte desolvation, ionization, transportation, and detection in a mass spectrometer. We provide a brief account of the scientific principles involved in developing an electrospray ion source, and in the various geometries used to improve the sensitivity of mass spectrometry. We also present some popular configurations currently available and outline future trends in this research area. (C) 2005 Elsevier Ltd. All rights reserved.}, keywords = {ANALYSIS SYSTEMS, atmospheric pressure ionization, ATMOSPHERIC-PRESSURE, CAPILLARY-ZONE-ELECTROPHORESIS, CHARGED DROPLETS, commercial ion source design, electrospray ionization, ion source, ion source geometry, mass, MICRO-ELECTROSPRAY, MICROFLUIDIC DEVICES, NANOSCALE LIQUID-CHROMATOGRAPHY, PRESSURE ION LENS, PROTEIN IDENTIFICATION, SOLUTION FLOW-RATES, SPECTROMETRY}, isbn = {0165-9936}, url = {://000236314000013}, author = {Manisali, I. and Chen, D. D. Y. and Schneider, B. B.} }