@article {11818,
	title = {Biosynthetic O-Methylation Protects Cladoniamides from Self-destruction.},
	journal = {Organic letters},
	volume = {15},
	year = {2013},
	month = {2013 May 2},
	pages = {2538{\textendash}2541},
	chapter = {2538},
	abstract = {Bisindole cladoniamides, nanomolar inhibitors of colon cancer cell line HCT-116, contain a rare, indolotryptoline substructure. In this report, the structures of xenocladoniamides A-E (9-13) are described. Compounds 9-13 are generated from a cladoniamide heterologous production system where O-methyltransferase gene claM3 has been inactivated. The results suggest that O-methylation, installed by enzyme ClaM3, is critical to maintaining the structural integrity of the indolotryptoline scaffold. Xenocladoniamides D and E are modestly cytotoxic against colon cancer cell line HCT-116.},
	issn = {1523-7052},
	doi = {10.1021/ol401036f},
	author = {Du, Yi Ling and Ding, Tong and Ryan, Katherine S}
}
