@article {1998,
	title = {An easy-to-use, regioselective, and robust bis(amidate) titanium hydroamination precatalyst: Mechanistic and synthetic investigations toward the preparation of tetrahydroisoquinolines and benzoquinolizine alkaloids},
	journal = {Chemistry-a European Journal},
	volume = {13},
	number = {7},
	year = {2007},
	note = {Zhang, Zhe Leitch, David C. Lu, Man Patrick, Brian O. Schafer, Laurel L.},
	pages = {2012-2022},
	abstract = {Amidate-supported titanium amido complexes are efficient and regioselective precatalysts for intermolecular hydroamination of terminal alkynes with primary amines. The synthesis and characterization of the first bis(amidate)-supported titanium-imido complex is reported. Its role as the active catalytic species is suggested in the course of product distribution studies using deuterated substrates. The bis (amidate)-supported precatalysts exhibit good functional-group tolerance, even performing hydroaminations in the presence of ester and amide groups. This functional-group tolerance was exploited in the synthesis of a variety of 1-substituted tetrahydroisoquinoline alkaloids and a one-pot hydroaminative procedure for the high yielding preparation of the benzo[a]quinolizine skeleton.},
	isbn = {0947-6539},
	url = {<Go to ISI>://000244914700011},
	author = {Zhang, Z. and Leitch, D. C. and Lu, M. and Patrick, B. O. and Schafer, L. L.}
}
