@article {1392,
	title = {Glucosamine conjugates of tricarbonylcyclopentadienyl rhenium(I) and technetium(I) cores},
	journal = {Inorganic Chemistry},
	volume = {45},
	number = {17},
	year = {2006},
	note = {ISI Document Delivery No.: 073DPTimes Cited: 13Cited Reference Count: 43Ferreira, Cara L. Ewart, Charles B. Bayly, Simon R. Patrick, Brian O. Steele, Jennifer Adam, Michael J. Orvig, Chris},
	month = {Aug},
	pages = {6979-6987},
	type = {Article},
	abstract = {To obtain a Tc-99m glucose conjugate for imaging, double-ligand transfer (DLT) and related reactions were examined for the preparation of CpM(CO)(3) (Cp = cyclopentadienyl; M = Re, Tc) complexes with pendant carbohydrates at Cp. Tricarbonyl {N-(1,3,4,6-tetra-O-acetyl-2-amino-2-deoxy-beta-D-glucopyranose) cyclopentadienyl carboxamide} rhenium(I) (1a) and tricarbonyl {N-(2-amino-2-deoxy-beta-D-glucopyranose) cyclopentadienyl carboxamide} rhenium(I) (2a) were prepared. The compounds were fully characterized by mass spectrometry, elemental analysis, IR, and NMR spectroscopy. Full assignment of the NMR spectra verified the pendant nature of the glucosamine moieties in the solution state and that 2a exists as both anomers. The solid-state structure of 2a was determined by X-ray crystallography, again confirming the pendant nature of the glucosamine, but differing from the solution state in that the, anomer crystallized preferentially (93\%). Compound 2a was determined to be a high-affinity competitive inhibitor (K-i = 330 +/- 70 mu M) of the glucose metabolism enzyme hexokinase, demonstrating that it retains certain biological activity. The Tc-99m analogues 1b and 2b were prepared in moderate radiochemical yields by means of the single-ligand transfer (SLT) route, which is more pertinent to radiopharmaceutical synthesis.},
	keywords = {BIOMOLECULES, COORDINATION, CYCLOPENTADIENYL-TRICARBONYL COMPLEXES, DERIVATIVES, FUNCTIONALIZATION, IN-VITRO, METAL-COMPLEXES, RE-186(I), RECEPTOR, TC-99M},
	isbn = {0020-1669},
	url = {<Go to ISI>://000239723300060},
	author = {Ferreira, C. L. and Ewart, C. B. and Bayly, S. R. and Patrick, B. O. and Steele, J. and Adam,Michael J. and Orvig, Chris}
}
@article {1392,
	title = {Glucosamine conjugates of tricarbonylcyclopentadienyl rhenium(I) and technetium(I) cores},
	journal = {Inorganic Chemistry},
	volume = {45},
	number = {17},
	year = {2006},
	note = {ISI Document Delivery No.: 073DPTimes Cited: 13Cited Reference Count: 43Ferreira, Cara L. Ewart, Charles B. Bayly, Simon R. Patrick, Brian O. Steele, Jennifer Adam, Michael J. Orvig, Chris},
	month = {Aug},
	pages = {6979-6987},
	type = {Article},
	abstract = {To obtain a Tc-99m glucose conjugate for imaging, double-ligand transfer (DLT) and related reactions were examined for the preparation of CpM(CO)(3) (Cp = cyclopentadienyl; M = Re, Tc) complexes with pendant carbohydrates at Cp. Tricarbonyl {N-(1,3,4,6-tetra-O-acetyl-2-amino-2-deoxy-beta-D-glucopyranose) cyclopentadienyl carboxamide} rhenium(I) (1a) and tricarbonyl {N-(2-amino-2-deoxy-beta-D-glucopyranose) cyclopentadienyl carboxamide} rhenium(I) (2a) were prepared. The compounds were fully characterized by mass spectrometry, elemental analysis, IR, and NMR spectroscopy. Full assignment of the NMR spectra verified the pendant nature of the glucosamine moieties in the solution state and that 2a exists as both anomers. The solid-state structure of 2a was determined by X-ray crystallography, again confirming the pendant nature of the glucosamine, but differing from the solution state in that the, anomer crystallized preferentially (93\%). Compound 2a was determined to be a high-affinity competitive inhibitor (K-i = 330 +/- 70 mu M) of the glucose metabolism enzyme hexokinase, demonstrating that it retains certain biological activity. The Tc-99m analogues 1b and 2b were prepared in moderate radiochemical yields by means of the single-ligand transfer (SLT) route, which is more pertinent to radiopharmaceutical synthesis.},
	keywords = {BIOMOLECULES, COORDINATION, CYCLOPENTADIENYL-TRICARBONYL COMPLEXES, DERIVATIVES, FUNCTIONALIZATION, IN-VITRO, METAL-COMPLEXES, RE-186(I), RECEPTOR, TC-99M},
	isbn = {0020-1669},
	url = {<Go to ISI>://000239723300060},
	author = {Ferreira, C. L. and Ewart, C. B. and Bayly, S. R. and Patrick, B. O. and Steele, J. and Adam,Michael J. and Orvig, Chris}
}
