@article {1267,
	title = {Carbohydrate-appended 2,2 {\textquoteright}-dipicolylamine metal complexes as potential imaging agents},
	journal = {Inorganic Chemistry},
	volume = {44},
	number = {8},
	year = {2005},
	note = {ISI Document Delivery No.: 916GWTimes Cited: 44Cited Reference Count: 58},
	month = {Apr},
	pages = {2698-2705},
	type = {Article},
	abstract = {Three discrete carbohydrate-appended 2,2{\textquoteright}-dipicolylamine ligands were complexed to the {M(CO)3}(+) (M = Tc-99m/ Re) core: 2-(bis(2-pyridinylmethyl)amino)ethyl-beta-D-glucopyranoside (L-1), 2-(bis(2-pyridinylmethyl)amino)ethyl-beta-Dxylopyranoside (L-2), and 2-(bis(2-pyridinylmethyl)amino)ethyl-alpha-D-mannopyranoside (L-3). An ethylene spacer is used to separate the carbohydrate moiety and the dipicolylamine (DPA) function in all three ligands. The Re complexes [Re(L1-3)(CO)(3)]Br were characterized by H-1 and C-13 1D/2D NMR spectroscopies, which confirmed the pendant nature of the carbohydrate moieties in solution. NMR measurements also established the long-range asymmetric effect of the carbohydrate functions on the chelating portion of the ligand. One analogue, [Re(L-1)(CO)(3)]Cl, was characterized in the solid state by X-ray crystallography. Further characterization was provided by IR spectroscopy, elemental analysis, conductivity, and mass spectrometry. Radiolabeling of L-1-L-3 with [Tc-99m(H2O)(3)(CO)(3)](+) afforded high yield compounds of identical character to the Re analogues. The radiolabeled compounds were found to be stable toward ligand exchange in the presence of a large excess of either cysteine or histidine over a 24-h period.},
	keywords = {AMINO-SUGARS, ANTITUMOR-ACTIVITY, BOMBESIN ANALOG, D-GLUCOSE, HIGH-AFFINITY, IN-VITRO, LIGANDS, PALLADIUM(II) COMPLEXES, RHENIUM CARBONYL-COMPLEXES, STRUCTURAL-CHARACTERIZATION, TRIDENTATE},
	isbn = {0020-1669},
	url = {<Go to ISI>://000228374400020},
	author = {Storr, T. and Sugai, Y. and Barta, C. A. and Mikata, Y. and Adam,Michael J. and Yano, S. and Orvig, Chris}
}
@article {1267,
	title = {Carbohydrate-appended 2,2 {\textquoteright}-dipicolylamine metal complexes as potential imaging agents},
	journal = {Inorganic Chemistry},
	volume = {44},
	number = {8},
	year = {2005},
	note = {ISI Document Delivery No.: 916GWTimes Cited: 44Cited Reference Count: 58},
	month = {Apr},
	pages = {2698-2705},
	type = {Article},
	abstract = {Three discrete carbohydrate-appended 2,2{\textquoteright}-dipicolylamine ligands were complexed to the {M(CO)3}(+) (M = Tc-99m/ Re) core: 2-(bis(2-pyridinylmethyl)amino)ethyl-beta-D-glucopyranoside (L-1), 2-(bis(2-pyridinylmethyl)amino)ethyl-beta-Dxylopyranoside (L-2), and 2-(bis(2-pyridinylmethyl)amino)ethyl-alpha-D-mannopyranoside (L-3). An ethylene spacer is used to separate the carbohydrate moiety and the dipicolylamine (DPA) function in all three ligands. The Re complexes [Re(L1-3)(CO)(3)]Br were characterized by H-1 and C-13 1D/2D NMR spectroscopies, which confirmed the pendant nature of the carbohydrate moieties in solution. NMR measurements also established the long-range asymmetric effect of the carbohydrate functions on the chelating portion of the ligand. One analogue, [Re(L-1)(CO)(3)]Cl, was characterized in the solid state by X-ray crystallography. Further characterization was provided by IR spectroscopy, elemental analysis, conductivity, and mass spectrometry. Radiolabeling of L-1-L-3 with [Tc-99m(H2O)(3)(CO)(3)](+) afforded high yield compounds of identical character to the Re analogues. The radiolabeled compounds were found to be stable toward ligand exchange in the presence of a large excess of either cysteine or histidine over a 24-h period.},
	keywords = {AMINO-SUGARS, ANTITUMOR-ACTIVITY, BOMBESIN ANALOG, D-GLUCOSE, HIGH-AFFINITY, IN-VITRO, LIGANDS, PALLADIUM(II) COMPLEXES, RHENIUM CARBONYL-COMPLEXES, STRUCTURAL-CHARACTERIZATION, TRIDENTATE},
	isbn = {0020-1669},
	url = {<Go to ISI>://000228374400020},
	author = {Storr, T. and Sugai, Y. and Barta, C. A. and Mikata, Y. and Adam,Michael J. and Yano, S. and Orvig, Chris}
}
