@article {509,
	title = {Synthesis and solution studies of the complexes of pyrone analogue ligands with vanadium(IV) and vanadium(V)},
	journal = {Inorganica Chimica Acta},
	volume = {339},
	year = {2002},
	note = {ISI Document Delivery No.: 616BDTimes Cited: 8Cited Reference Count: 16},
	month = {Nov},
	pages = {393-399},
	type = {Article},
	abstract = {A new potentially tetradentate chelator N,N{\textquoteright}-bis(3-hydroxy-6-methyl-2-methylene-4-pyrone)ethylenediamine (H-2(en(ama)(2))), has been synthesized and its protonation constants, as well as those of two other 3-hydroxy-4-pyrone ligands (allomaltol (Hama) and methylmaltol (Hmma)) determined potentiometrically at 25 degreesC and 0.16 M NaCl: pK(a1) = 3.67+/-0.07, pK(a2) = 5.82+/-0.07, pK(a3) = 7.96+/-0.04, pK(a4) = 8.77+/-0.03 for [H-4(en(ama)(2))](2+), pK(a) = 8.04+/-0.02 for Hama and pK(a) = 8.82+/-0.02 for Hmma. Potentiometric pH titrations were also used to measure the stability constants of these ligands with V(IV) and V(V) and to study the structures of the complexes of (en(ama)(2))(2-) in aqueous solution. H-1 NMR was used to assign the protonation constant values to the different protons in H-2(en(ama)(2)). A pM versus pH plot confirmed that H-2(en(ama)(2)) has much stronger complexation than its bidentate analogues, in the same pH range. (C) 2002 Elsevier Science B.V. All rights reserved.},
	keywords = {AQUEOUS-SOLUTION, BIS(MALTOLATO)OXOVANADIUM(IV), GLUCOSE, insulin drugs, ION-COORDINATING PROPERTIES, potentiometry, stability constants, vanadium complexes},
	isbn = {0020-1693},
	url = {<Go to ISI>://000179281100048},
	author = {Song, B. and Saatchi, K. and Rawji, G. H. and Orvig, Chris}
}
@article {5209,
	title = {Coordination chemistry of vanadium in metallopharmaceutical candidate compounds},
	journal = {Coordination Chemistry Reviews},
	volume = {219},
	year = {2001},
	note = {ISI Document Delivery No.: 478JQTimes Cited: 138Cited Reference Count: 119},
	month = {Sep-Oct},
	pages = {1033-1053},
	type = {Review},
	abstract = {The discovery of vanadium{\textquoteright}s insulin-like behaviour in vitro, and later of the orally available glucose- and lipid-lowering capability of these same compounds in vivo, has stimulated renewed interest in vanadium coordination chemistry. Besides the anti-diabetic effects for which it is now so well known, vanadium also exhibits a number of other therapeutic effects including anti-tumour and anti-inflammatory activities. In this review, emphasis will be on the most recent developments in the coordination chemistry of vanadium(III), (IV) and (V), as related to development of these compounds for pharmaceutical use. How best to measure bioactivity and the pharmaceutical relevance of accompanying increased oxidative stress will also be considered. (C) 2001 Elsevier Science B.V. All rights reserved.},
	keywords = {bioactivity, BIOLOGICAL-ACTIVITY, CANCER, CRYSTAL-STRUCTURE, Diabetes mellitus, DIABETES-MELLITUS, ESEEM, INSULIN-LIKE ACTIVITIES, OXIDATIVE STRESS, OXOVANADIUM(IV) COMPLEXES, OXYGEN-BRIDGED DIMER, PEROXO HETEROLIGAND VANADATES(V), pharmaceutical agents, RAY, SPECTROSCOPIC PROPERTIES, structure-activity relationships, TYROSINE PHOSPHORYLATION, vanadium complexes},
	isbn = {0010-8545},
	url = {<Go to ISI>://000171343600035},
	author = {Thompson, K. H. and Orvig, Chris}
}
