@article {4410,
	title = {Complexation of gallium(III) by 2-hydroxynicotinic acid and 3-hydroxypicolinic acid in aqueous solution},
	journal = {Inorganica Chimica Acta},
	volume = {273},
	number = {1-2},
	year = {1998},
	note = {ISI Document Delivery No.: ZP204Times Cited: 17Cited Reference Count: 27XXXIII International Conference on Coordination ChemistryAUG 30-SEP 04, 1998FLORENCE, ITALY},
	month = {May},
	pages = {47-53},
	type = {Proceedings Paper},
	abstract = {The deprotonations of 2-hydroxynicotinic acid (H(2)nic) and 3-hydroxypicolinic acid (H(2)pic) and the complexation of these molecules with Ga3+ were studied by H-1 NMR, UV-Vis spectrophotometry and potentiometric titration. Both ligands bind Ga3+ at very low pH; the ligand binds in the monodeprotonated form. The stability constants of the [Ga(HL)(n)]((3-n)+) (L = nic or pic; n = 1, 2, or 3) complexes were measured at 25 degrees C, 1.0 M NaCl (for beta(1)) and 0.16 M NaCl (for beta(2) and beta(3)); for H(2)nic (H(2)pic), log beta(1) = 6.78 (7.04), log beta(2) = 12.43 (13.09) and log beta(3) = 16.20 (17.74). At higher pH, polynuclear mixed ligand-hydroxo species form, although their composition and stability could not be determined. These complexes undergo hydrolysis to form [Ga(OH)(4)](-) above pH 7. (C) 1998 Elsevier Science S.A. All rights reserved.},
	keywords = {3-HYDROXY-4-PYRIDINONES, aluminum, CHELATION, CHEMISTRY, COMPLEXES, EQUILIBRIUM, GA-68, gallium complexes, hydroxynicotinic acid, hydroxypicolinic acid complexes, INDIUM COMPLEXES, INVIVO, LIGANDS, RADIOPHARMACEUTICALS},
	isbn = {0020-1693},
	url = {<Go to ISI>://000073728200008},
	author = {Stephens, A. K. W. and Orvig, Chris}
}
@article {7397,
	title = {POTENTIAL GA-67 RADIOPHARMACEUTICALS FOR MYOCARDIAL IMAGING - TRIS(1-ARYL-3-HYDROXY-2-METHYL-4-PYRIDINONATO)GALLIUM(III) COMPLEXES},
	journal = {Nuclear Medicine and Biology},
	volume = {19},
	number = {3},
	year = {1992},
	note = {ISI Document Delivery No.: HL213Times Cited: 36Cited Reference Count: 33},
	month = {Apr},
	pages = {327-335},
	type = {Article},
	abstract = {A series of highly lipophilic complexes of 1-aryl-3-hydroxy-2-methyl-4-pyridinones with gallium(III)-67 has been evaluated in vitro and in vivo as potential radiopharmaceuticals. The pyridinones have different substituents at the para -position of the phenyl ring: R = H, CH3, OCH3 and NO2. Biodistribution studies of Ga-67 complexes have been carried out in rabbits, mice, rats and a dog. High heart uptake of the radionuclide has been shown in rabbits and the dog. The different biodistribution patterns in mice and rats indicate that there is a species difference in the biodistribution of these complexes. Rabbits and the dog show rapid heart uptake and blood clearance. The speciation of the Ga3+ ion in vivo is simulated in vitro with a simple blood plasma model based on the available thermodynamic data.},
	keywords = {3-HYDROXY-4-PYRIDINONES, aluminum, BIODISTRIBUTION, CHELATING LIGAND, CHEMISTRY, gallium, INDIUM COMPLEXES, MULTIDENTATE LIGANDS, N, N{\textquoteright}-DIACETIC ACID, N{\textquoteright}-DIPYRIDOXYLETHYLENEDIAMINE-N, TRIVALENT METAL-IONS},
	isbn = {0883-2897},
	url = {<Go to ISI>://A1992HL21300012},
	author = {Zhang, Z. H. and Lyster, D. M. and Webb, G. A. and Orvig, Chris}
}
