@article {WANG2024139004,
	title = {Strategies for using magnetic beads in enhanced deep eutectic solvent-mechanochemical extraction of natural products from orange peels},
	journal = {Food Chemistry},
	volume = {447},
	year = {2024},
	pages = {139004},
	abstract = {To address the challenges of low recovery, prolonged extraction times, and environmental pollution caused by toxic solvents in traditional extraction methods, magnetic bead-enhanced deep eutectic solvent mechanochemical extraction was developed for extracting natural products from orange peels. The extraction efficiencies of deep eutectic solvents were experimentally evaluated, and theoretical methods were used to guide solvent selection. Choline chloride-ethylene glycol demonstrated the highest efficiency under the optimal extraction conditions: a molar ratio of 1:2, no water content, a solid-liquid ratio of 0.08~g/mL, and an extraction time of 60~s. The synergy between the deep eutectic solvent and magnetic bead-enhanced the mechanochemical extraction efficiencies. The study also examined the effects of different magnetic bead types and orange peel powder particle sizes on extraction efficiency, finding that a 0.11~mm particle size combined with CIP@SiO2 yielded the best results. Overall, this study holds promise as an environmentally friendly and efficient extraction method.},
	keywords = {Deep eutectic solvents, Hydrogen bond donors and acceptors, Magnetic beads, Mechanochemical extraction, natural products, Orange peel},
	issn = {0308-8146},
	doi = {https://doi.org/10.1016/j.foodchem.2024.139004},
	url = {https://www.sciencedirect.com/science/article/pii/S0308814624006538},
	author = {Zhaoyang Wang and Wuxia Ge and Wentao Bi and David Da Yong Chen}
}
@article {JIANG2019,
	title = {Simultaneous determination of multiple components in cigarettes by mechanochemical extraction and direct analysis in real time mass spectrometry in minutes},
	journal = {Analytica Chimica Acta},
	volume = {1057},
	year = {2019},
	month = {05/2019},
	pages = {70-79},
	abstract = {<p>A simple, rapid and high throughput analytical approach with combination of mechanochemical extraction (MCE) and direct analysis in real time mass spectrometry (DART-MS) analysis was developed for the simultaneous determination of multiple chemical components in cigarette fillers. Different kinds of substances including nicotine, cigarette alkaloids, carbohydrates, organic acids, humectants and other additives were successfully extracted using MCE and detected by high resolution DART-MS. Six solvents of various polarities were compared during MCE process and significant differences were observed. Different brands of cigarettes as well as standard research cigarette exhibited distinctive chemical features and DART-MS fingerprints. Principle component analysis showed clear differentiation among different cigarettes extracted with the same solvent and different solvent extracts of the same type of cigarette. The putative chemical formulas were proposed based on accurate m/z values with \&lt;10 ppm mass errors. The relative contents of nicotine and other identified substances were compared and significant differences were observed among cigarettes of different locations. The whole procedure of MCE combined with DART-MS only takes minutes from raw cigarette fillers to obtaining the semi-quantitative results. The operation is simple and high throughput, providing an efficient method to analyze cigarette composition, and to establish a methodology to acquire the rapid cigarette fingerprints for quality control.</p>},
	keywords = {Cigarette filler, direct analysis in real time mass spectrometry, Mechanochemical extraction, Principle component analysis},
	issn = {0003-2670},
	doi = {https://doi.org/10.1016/j.aca.2019.01.024},
	url = {http://www.sciencedirect.com/science/article/pii/S0003267019300935},
	author = {Qing Jiang and Diya Dai and Hongli Li and David D.Y. Chen}
}
