@article {2118,
	title = {Unimolecular Micelles based on Hydrophobically Derivatized Hyperbranched Polyglycerols: Biodistribution Studies},
	journal = {Bioconjugate Chemistry},
	volume = {19},
	number = {11},
	year = {2008},
	note = {ISI Document Delivery No.: 373VOTimes Cited: 7Cited Reference Count: 31Kainthan, Rajesh Kumar Brooks, Donald E.},
	month = {Nov},
	pages = {2231-2238},
	type = {Article},
	abstract = {We recently reported the synthesis and testing of a new class of unimolecular micelles based on hyperbranched polyglycerols as second generation synthetic plasma expanders and as general drug delivery vehicles. A detailed biodistribution study of two derivatized hyperbranched polyglycerols of different molecular weights derivatized with hydrophobic groups and short poly(ethylene glycol) chains is reported in this article. In mice, these materials are nontoxic with circulation half-lives as high as 31 h, controllable by manipulating the molecular weight and the degree of PEG derivatization. Organ accumulation is low, presumably due to the "pegylation" effect. Thermal degradation and hydrolysis data suggest that these polymers are highly stable with a long shelf life, a major advantage for a pharmaceutical product. Degradation under acidic conditions has been observed for these polymers.},
	keywords = {ALBUMIN, BIOLOGICAL EVALUATION, DENDRIMERS, IMMUNOGENICITY, IN-VIVO, LIPOSOMES, MOLECULAR-WEIGHT, POLYETHYLENE-GLYCOL DEGRADATION, POLYMERS, STARCH},
	isbn = {1043-1802},
	url = {<Go to ISI>://000261001800018},
	author = {Kainthan, R. K. and Brooks, D. E.}
}
@article {916,
	title = {Atom transfer radical polymerization using multidentate amine ligands supported on soluble hyperbranched polyglycidol},
	journal = {Macromolecular Chemistry and Physics},
	volume = {205},
	number = {5},
	year = {2004},
	note = {ISI Document Delivery No.: 811MBTimes Cited: 12Cited Reference Count: 31},
	month = {Mar},
	pages = {567-573},
	type = {Article},
	abstract = {Controlled polymerization of styrene in toluene was achieved by atom transfer radical polymerization (ATRP) using hyperbranched polyglycidol-supported multidentate amine ligands/(CuBr)-Br-I catalyst systems. These catalyst systems with nanoscopic dimensions were more active than the corresponding low-molecular-weight ligands. The controlled/living nature of the polymerization is supported by linear first order plots (ln[M](o)/[M] versus time) and a linear increase of (M) over bar (n) versus conversion as well as low polydispersity. Similar controlled polymerization of methyl methacrylate was possible in acetonitrile. Up to 97\% of total copper used for polymerization could be removed from the polymer by simple precipitation in methanol and filtration.},
	keywords = {AMBIENT-TEMPERATURE, atom transfer radical polymerization (ATRP), ATRP, branched, CATALYST, CATALYSTS, COPPER BROMIDE, DENDRIMERS, METHYL-METHACRYLATE, polystyrene, ROMP},
	isbn = {1022-1352},
	url = {<Go to ISI>://000220774900002},
	author = {Kumar, K. R. and Kizhakkedathu, J. N. and Brooks, D. E.}
}
