@article {2243,
	title = {Altering pyridinone N-substituents to optimise activity as potential prodrugs for Alzheimer{\textquoteright}s disease},
	journal = {Dalton Transactions},
	number = {45},
	year = {2008},
	note = {ISI Document Delivery No.: 371METimes Cited: 5Cited Reference Count: 29Scott, Lauren E. Page, Brent D. G. Patrick, Brian O. Orvig, Chris},
	pages = {6364-6367},
	type = {Article},
	abstract = {Selective design modifications of specifically substituted 3-hydroxy-4(1H)-pyridinones show possibly advantageous ring freedom while maintaining metal-binding ability and antioxidant capacity, moving toward an efficient potential treatment for Alzheimer{\textquoteright}s disease.},
	keywords = {aluminum, BLOOD-BRAIN-BARRIER, COMPLEXES, DISORDERS, DIVALENT, IRON CHELATORS, PENETRATION, STABILITIES, therapy, TRIVALENT METAL-IONS},
	isbn = {1477-9226},
	url = {<Go to ISI>://000260834600005},
	author = {Scott, L. E. and Page, B. D. G. and Patrick, B. O. and Orvig, Chris}
}
@article {1428,
	title = {Blood compatibility of novel water soluble hyperbranched polyglycerol-based multivalent cationic polymers and their interaction with DNA},
	journal = {Biomaterials},
	volume = {27},
	number = {31},
	year = {2006},
	note = {ISI Document Delivery No.: 085NOTimes Cited: 48Cited Reference Count: 41Kainthan, Rajesh Kumar Gnanamani, Muthiah Ganguli, Munia Ghosh, Tanay Brooks, Donald E. Maiti, Souvik Kizhakkedathu, Jayachandran N.},
	month = {Nov},
	pages = {5377-5390},
	type = {Article},
	abstract = {A novel class of hyperbranched polymers based on polyglycerol (PG) and poly(ethylene glycol) (PEG) are synthesized by multibranching anionic ring opening polymerization. Multivalent cationic sites are added to these polymers by a post-amination and quarternization reactions. Blood compatibility studies using these polymers at different concentrations showed insignificant effects on complement activation, platelet activation, coagulation, erythrocyte aggregation and hemolysis compared to branched cationic polyethyleneimine (PEI). The degree of quarternization does not have large influence on the blood compatibility of the new polymers. Cytotoxicity of these polymers is significantly lower than that of PEI and is a function of quarternized nitrogen present in the polymer. Also, these polymers bind DNA in the nanomolar range and are able to condense DNA to highly compact, stable, water soluble nanoparticles in the range of 60-80 nm. Gel electrophoresis studies showed that they form electroneutral complexes with DNA around N/P ratio 1 irrespective of the percentage of quarternization under the conditions studied. (c) 2006 Elsevier Ltd. All rights reserved.},
	keywords = {AFM, blood-compatibility, cationic polymers, COAGULATION, COMPLEXES, delivery, DNA, drug, GENE DELIVERY, hyperbranched polymers, IN-VITRO, MOLECULAR-WEIGHT, NANOPARTICLES, OPPOSITELY CHARGED SURFACTANT, PLATELETS, RANDOM COPOLYMER, therapy},
	isbn = {0142-9612},
	url = {<Go to ISI>://000240611000005},
	author = {Kainthan, R. K. and Gnanamani, M. and Ganguli, M. and Ghosh, T. and Brooks, D. E. and Maiti, S. and Kizhakkedathu, J. N.}
}
@article {1577,
	title = {Design of targeting ligands in medicinal inorganic chemistry},
	journal = {Chemical Society Reviews},
	volume = {35},
	number = {6},
	year = {2006},
	note = {ISI Document Delivery No.: 047UHTimes Cited: 58Cited Reference Count: 51},
	pages = {534-544},
	type = {Review},
	abstract = {This tutorial review will highlight recent advances in medicinal inorganic chemistry pertaining to the use of multifunctional ligands for enhanced effect. Ligands that adequately bind metal ions and also include specific targeting features are gaining in popularity due to their ability to enhance the efficacy of less complicated metal-based agents. Moving beyond the traditional view of ligands modifying reactivity, stabilizing specific oxidation states, and contributing to substitution inertness, we will discuss recent work involving metal complexes with multifunctional ligands that target specific tissues, membrane receptors, or endogenous molecules, including enzymes.},
	keywords = {CANCER, COMPLEXES, FLUORESCENCE, GADOLINIUM, IN-VITRO, PARACEST AGENTS, PROTEINS, RECEPTOR, therapy, TRANSPORT},
	isbn = {0306-0012},
	url = {<Go to ISI>://000237903700005},
	author = {Storr, T. and Thompson, K. H. and Orvig, Chris}
}
@article {1600,
	title = {Metal complexes in medicinal chemistry: new vistas and challenges in drug design},
	journal = {Dalton Transactions},
	number = {6},
	year = {2006},
	note = {ISI Document Delivery No.: 014YVTimes Cited: 60Cited Reference Count: 44},
	month = {Feb},
	pages = {761-764},
	type = {Article},
	abstract = {An overview is presented of selected metal-bases! pharmaceuticals, either diagnostic or therapeutic, with emphasis on specific attributes and in vivo interactions of these compounds relevant to their use in medicinal applications. Both the advantages and the challenges of this approach are outlined, with possibilities for future developments accentuated.},
	keywords = {AGENTS, BINDING CONSTANTS, BIS(MALTOLATO)OXOVANADIUM(IV), GLUCOSE, HUMAN-SERUM TRANSFERRIN, MODULATION, therapy, TRANSPORT},
	isbn = {1477-9226},
	url = {<Go to ISI>://000235520000001},
	author = {Thompson, K. H. and Orvig, Chris}
}
@article {1241,
	title = {Coordination chemistry and insulin-enhancing behavior of vanadium complexes with maltol C6H6O3 structural isomers},
	journal = {Inorganic Chemistry},
	volume = {44},
	number = {8},
	year = {2005},
	note = {ISI Document Delivery No.: 916GWTimes Cited: 19Cited Reference Count: 49},
	month = {Apr},
	pages = {2689-2697},
	type = {Article},
	abstract = {Syntheses of vanadium complexes using the naturally occurring ligands isomaltol (Hima) and allomaltol (Hama), as well as a newly synthesized, potentially tetradentate diaminodipyrone [H-2(en(ama)(2)], are reported. Complete characterization of the resulting compounds [trans-VO(ima)(2)(H2O), VO(ama)(2), V(ima)(3), V(ama)(3) and VO(en(ama)(2))], including X-ray crystallography analyses for trans-VO(ima)(2)(H2O) and V(ima)3, are presented herein. Potentiometric titrations (25 degrees C, / = 0.16 M NaCl) were used to measure stability constants in the V(IV)-Hima system; these data were compared to previous data collected on the V(IV)-L (L = Hma, Hama) systems. The in vivo efficacy of these compounds to lower the blood glucose levels of STZ-diabetic rats was tested; all but VO(en(ama)2) produced significant decreases in plasma glucose levels. The results were compared to those of the benchmark compound BMOV [VO(ma)(2), bis(maltolato)oxovanadium(IV)], a known insulin-enhancing agent.},
	keywords = {aluminum, BIS(MALTOLATO)OXOVANADIUM(IV), CRYSTAL-STRUCTURE, DIABETIC-RATS, ISOMALTOL, LIGANDS, REFINEMENT, SPECIATION, therapy, VANADATE},
	isbn = {0020-1669},
	url = {<Go to ISI>://000228374400019},
	author = {Saatchi, K. and Thompson, K. H. and Patrick, B. O. and Pink, M. and Yuen, V. G. and McNeill, J. H. and Orvig, Chris}
}
@article {435,
	title = {Evaluation of tetraphenyl-2,3-dihydroxychlorins as potential photosensitizers},
	journal = {Journal of Porphyrins and Phthalocyanines},
	volume = {6},
	number = {2},
	year = {2002},
	note = {ISI Document Delivery No.: 595XYTimes Cited: 15Cited Reference Count: 33},
	pages = {146-155},
	type = {Article},
	abstract = {A series of beta,beta-dihydroxychlorins derived from meso-tetraphenylporphyrins (TPPs) have been synthesized. Their in vitro cytotoxicity has been measured and compared to BPDMA (verteporfin). Under the assay conditions BPDMA had an LD50 (lethal dose to kill 50\% of cells) value of 0.007 muM (5 ng/mL). The LD50 values for the TPP derivatives varied from 1.7 x 10(-2) to 9.9 muM depending upon the substituents and their position on the phenyl groups. One example of the dihydroxychlorin prepared from unsubstituted 5,15-diphenylporphyrin was examined and this exhibited an LD50 of 2.4 x 10(-3) muM! Copyright (C) 2002 Society of Porphyrins \& Phthalocyanines.},
	keywords = {AGGREGATION, BACTERIOCHLORINS, beta, beta-dihydroxychlorins, BIODISTRIBUTION, chlorins, cytotoxicity, DERIVATIVES, photodynamic, PHOTODYNAMIC THERAPY, PHOTOPHYSICAL PROPERTIES, PHOTOSENSITIZERS, porphyrins, PROTEIN-BINDING, SENSITIZERS, therapy, TUMOR PHOTOSENSITIZERS},
	isbn = {1088-4246},
	url = {<Go to ISI>://000178134600008},
	author = {Macalpine, J. K. and Boch, R. and Dolphin, D.}
}
@article {5046,
	title = {Aggregation studies of benzoporphyrin derivative},
	journal = {Canadian Journal of Chemistry-Revue Canadienne De Chimie},
	volume = {79},
	number = {5-6},
	year = {2001},
	note = {ISI Document Delivery No.: 456EVTimes Cited: 11Cited Reference Count: 33},
	month = {May},
	pages = {1068-1074},
	type = {Article},
	abstract = {The photophysical properties of a ring B benzoporphyrin derivative 1,3-diene dimethylester were investigated in solution (water-DMSO mixtures). At low proportions of water in DMSO, the diester obeys Beer{\textquoteright}s law at all pH values and ionic strengths investigated. For solvent systems containing more than 30\% water, the extent of deviation from Beer{\textquoteright}s law as a function of porphyrin concentration is attributed to formation of porphyrin dimers. Dimerization equilibrium constants (Kd) have been determined in different percentage of solvent mixtures, using absorption and fluorescence spectroscopies, and were found to exhibit a linear correlation between log (Kd) and the inverse of the dielectric constant (log (Kd) = 24.6 - 1060.4 x 1/epsilon (mix)). This equation permits the calculation of Kd in mixtures of water-DMSO.},
	keywords = {AGGREGATION, benzoporphyrin, BPD, DERIVATIVE, DIMERIZATION, FLUORESCENCE, PHOTODYNAMIC THERAPY, PHOTOSENSITIZERS, porphyrins, SPECTROSCOPY, therapy},
	isbn = {0008-4042},
	url = {<Go to ISI>://000170070900079},
	author = {Delmarre, D. and Hioka, N. and Boch, R. and Sternberg, E. and Dolphin, D.}
}
@article {4063,
	title = {Chemical modification of chlorophyll a: Synthesis of new regiochemically pure benzoporphyrin and dibenzoporphyrin derivatives},
	journal = {Canadian Journal of Chemistry-Revue Canadienne De Chimie},
	volume = {75},
	number = {3},
	year = {1997},
	note = {ISI Document Delivery No.: XD813Times Cited: 10Cited Reference Count: 28},
	month = {Mar},
	pages = {262-275},
	type = {Article},
	abstract = {Starting from pheophorbide a methyl ester (5), a degradation product of chlorophyll a, routes for the preparation of 3-vinylporphyrins 6 and 9 and of an [A,C]-divinylporphyrin 16 are described. These porphyrins were obtained as a result of chemical modification of 5 on ring D and the exocyclic ring E. Diels-Alder reactions of these (di)vinylporphyrins with dimethyl acetylenedicarboxylate, to afford new regiochemically pure benzoporphyrin derivatives 29 and 30 and dibenzoporphyrin derivative 33 for potential use as sensitizers in photodynamic therapy of tumors, were also investigated.},
	keywords = {(di)benzoporphyrins, (di)vinylporphyrins, chlorins, CHLOROPHYLL, CONVERSION, Diels-Alder, ESTERS, photodynamic, PHOTODYNAMIC THERAPY, ROUTE, therapy},
	isbn = {0008-4042},
	url = {<Go to ISI>://A1997XD81300003},
	author = {Ma, L. F. and Dolphin, D.}
}
