@article {2542,
	title = {Paclitaxel incorporated in hydrophobically derivatized hyperbranched polyglycerols for intravesical bladder cancer therapy},
	journal = {Bju International},
	volume = {103},
	number = {7},
	year = {2009},
	note = {ISI Document Delivery No.: 417GSTimes Cited: 6Cited Reference Count: 37Mugabe, Clement Hadaschik, Boris A. Kainthan, Rajesh K. Brooks, Donald E. So, Alan I. Gleave, Martin E. Burt, Helen M.},
	month = {Apr},
	pages = {978-986},
	type = {Article},
	abstract = {To develop paclitaxel incorporated into unimolecular micelles based on hydrophobically derivatized hyperbranched polyglycerols (dHPGs) for use as mucoadhesive intravesical agents against non-muscle-invasive bladder cancer. Two different types of dHPGs (HPG- C10-polyethylene glycol (PEG) and polyethyleneimine (PEI)-C18-HPG) were synthesized and paclitaxel was loaded into these using a solvent evaporation method. After physicochemical characterization of the resulting nanoparticles, four human bladder cancer cell lines were incubated with various concentrations of paclitaxel incorporated in dHPGs and the results were compared with those of paclitaxel formulated in Cremophor-EL (Taxol (R), Bristol-Myers-Squibb). In vivo, nude mice with orthotopic KU7-luc tumours were intravesically instilled with phosphate buffered saline, Taxol, or paclitaxel/HPG-C10-PEG. dHPGs are mucoadhesive nanoparticles with hydrodynamic radii of < 10 nm and incorporation of paclitaxel did not affect their size. The release profiles of paclitaxel from dHPGs were characterized by a rapid-release phase followed by a slower sustained-release phase. While the PEI-C18-HPG formulation released only approximate to 40\% of the initially incorporated paclitaxel, up to 80\% was released from HPG-C10-PEG. Moreover, only paclitaxel/HPG-C10-PEG was stable in acidic urine. In vitro, all paclitaxel formulations potently decreased bladder cancer proliferation although paclitaxel/HPG-C10-PEG was slightly less cytotoxic than standard Taxol. By contrast, in vivo, the mucoadhesive HPG-C10-PEG formulation of paclitaxel was significantly more effective in reducing orthotopic tumour growth than Taxol and was well tolerated. Intravesical administration of mucoadhesive nanoparticulate formulations of paclitaxel might be a promising approach for instillation therapy of patients with non-muscle-invasive bladder cancer.},
	keywords = {ARCHITECTURES, bladder cancer, chemotherapy, DESIGN, DRUG-DELIVERY, hyperbranched polyglycerols, intravesical therapy, MANAGEMENT, MICROSPHERES, MUCOADHESION, orthotopic mouse model, PACLITAXEL, pharmacokinetics, POLYMERS, unimolecular micelles},
	isbn = {1464-4096},
	url = {<Go to ISI>://000264065100022},
	author = {Mugabe, C. and Hadaschik, B. A. and Kainthan, R. K. and Brooks, D. E. and So, A. I. and Gleave, M. E. and Burt, H. M.}
}
@article {2376,
	title = {Plectosphaeroic Acids A, B, and C, Indoleamine 2,3-Dioxygenase Inhibitors Produced in Culture by a Marine Isolate of the Fungus Plectosphaerella cucumerina},
	journal = {Organic Letters},
	volume = {11},
	number = {14},
	year = {2009},
	note = {ISI Document Delivery No.: 472NMTimes Cited: 1Cited Reference Count: 29Carr, Gavin Tay, Wendy Bottriell, Helen Andersen, Sarah K. Mauk, A. Grant Andersen, Raymond J.},
	month = {Jul},
	pages = {2996-2999},
	type = {Article},
	abstract = {Laboratory cultures of the fungus Plectosphaerella cucumerina obtained from marine sediments collected in Barkley Sound, British Columbia, yielded the novel alkaloids plectosphaeroic acids A (1) to C (3). The alkaloids 1-3 are inhibitors of indoleamine 2,3-dioxygenase (IDO).},
	keywords = {CANCER, CELLS, chemotherapy, EXIGUAMINE-A, EXPRESSION, IDO, MECHANISM, METABOLITES, SUPPRESSION, TRYPTOPHAN DEGRADATION},
	isbn = {1523-7060},
	url = {<Go to ISI>://000268138800011},
	author = {Carr, G. and Tay, W. and Bottriell, H. and Andersen, S. K. and Mauk, A. G. and Andersen, R. J.}
}
@article {2037,
	title = {Synthesis of indoleamine 2,3-dioxygenase inhibitory analogues of the sponge alkaloid exiguamine A},
	journal = {Journal of Medicinal Chemistry},
	volume = {51},
	number = {9},
	year = {2008},
	note = {ISI Document Delivery No.: 295USTimes Cited: 17Cited Reference Count: 20Carr, Gavin Chung, Marco K. W. Mauk, A. Grant Andersen, Raymond J.},
	month = {May},
	pages = {2634-2637},
	type = {Article},
	abstract = {Synthetic analogues of the sponge natural product exiguamine A (3) have been prepared and evaluated for their ability to inhibit indoleamine 2,3-dioxygenase in vitro.},
	keywords = {CANCER, CATABOLISM, CELLS, chemotherapy, EXPRESSION, IDO, IMMUNE TOLERANCE, MECHANISM, SMALL-MOLECULE INHIBITORS, TRYPTOPHAN DEGRADATION},
	isbn = {0022-2623},
	url = {<Go to ISI>://000255500000008},
	author = {Carr, G. and Chung, M. K. W. and Mauk, A. G. and Andersen, R. J.}
}
@article {1522,
	title = {Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific marine hydroid Garveia annulata},
	journal = {Journal of Natural Products},
	volume = {69},
	number = {10},
	year = {2006},
	note = {ISI Document Delivery No.: 098ZQTimes Cited: 17Cited Reference Count: 20Pereira, Alban Vottero, Eduardo Roberge, Michel Mauk, A. Grant Andersen, Raymond J.},
	month = {Oct},
	pages = {1496-1499},
	type = {Article},
	abstract = {Crude extracts of the marine hydroid Garveia annulata show potent inhibition of indoleamine 2,3-dioxygenase (IDO). Fractionation of the extract led to the identification of the new polyketides annulin C (1), 2-hydroxygarveatin E (4), garveatin E (5), and garvin C (9). Annulins A (2), B (3), and C (1) were found to be submicromolar inhibitors of IDO.},
	keywords = {CANCER, chemotherapy, ENZYME, HUMAN LENS, MECHANISM, METABOLITES, NUCLEAR CATARACT, REJECTION, TOLERANCE, TRYPTOPHAN DEGRADATION},
	isbn = {0163-3864},
	url = {<Go to ISI>://000241562700025},
	author = {Pereira, A. and Vottero, E. and Roberge, M. and Mauk, A. G. and Andersen, R. J.}
}
@article {1407,
	title = {Sulfated meroterpenoids from the Brazilian sponge Callyspongia sp. are inhibitors of the antileishmaniasis target adenosine phosphoribosyl transferase},
	journal = {Journal of Organic Chemistry},
	volume = {71},
	number = {23},
	year = {2006},
	note = {ISI Document Delivery No.: 101QKTimes Cited: 14Cited Reference Count: 23Gray, Christopher A. de Lira, Simone P. Silva, Marcio Pimenta, Eli F. Thiemann, Otavio H. Oliva, Glaucius Hajdu, Eduardo Andersen, Raymond J. Berlinck, Roberto G. S.},
	month = {Nov},
	pages = {8685-8690},
	type = {Article},
	abstract = {Three new disulfated meroterpenoids, ilhabelanol (1), ilhabrene (2), and isoakaterpin (3), have been isolated from extracts of the Brazilian marine sponge Callyspongia sp. Isoakaterpin (3) inhibits Leishmania spp. adenosine phosphoribosyl transferase with an IC50 of 1.05 mu M. The structures of 1, 2, and 3 were elucidated by analysis of one- and two-dimensional NMR data. Ilhabelanol (1) and ilhabrene (2) both have unprecedented meroterpenoid carbon skeletons.},
	keywords = {AKA ADOCIA SP, AKATERPIN, chemotherapy, DRUGS, HEXAPRENOID HYDROQUINONES, LEISHMANIASIS, NATURAL-PRODUCTS, TOXICLONA-TOXIUS},
	isbn = {0022-3263},
	url = {<Go to ISI>://000241755300001},
	author = {Gray, C. A. and de Lira, S. P. and Silva, M. and Pimenta, E. F. and Thiemann, O. H. and Oliva, G. and Hajdu, E. and Andersen, R. J. and Berlinck, R. G. S.}
}
@article {7365,
	title = {INVITRO SCREENING OF CRUDE EXTRACTS AND PURE METABOLITES OBTAINED FROM MARINE-INVERTEBRATES FOR THE TREATMENT OF BREAST-CANCER},
	journal = {Cancer Chemotherapy and Pharmacology},
	volume = {30},
	number = {5},
	year = {1992},
	note = {ISI Document Delivery No.: JG989Times Cited: 31Cited Reference Count: 27},
	month = {Sep},
	pages = {401-406},
	type = {Article},
	abstract = {A total of 15 samples (crude extracts and pure secondary metabolites) obtained from marine invertebrates collected from the offshore waters of British Columbia, Papua New Guinea, and Sri Lanka have previously been shown to exert cytotoxic activity in the in vitro L1210 leukemic bioassay. We screened these metabolites for in vitro cytotoxic activity against the drug-sensitive breast-tumor cell lines MCF-7, T-47D, ZR-75- 1, and MDA-MB23 1; the multidrug-resistant and P-glycoprotein (Pgp)-positive breast-tumor cell lines MCF-7 Ad(r) and MDA-Al(r); and normal and malignant human breast epithelial cells (HBEC) in primary culture. Eight samples exhibited significant [drug concentration resulting in a 50\% decrease in cell growth as compared with controls (ED50), <25-mu-g/ml] dose-dependent cytotoxicity against the drug-sensitive cell lines; the ED50 values were as low as 0.004-mu-g/ml. Five of the eight samples exhibited significant cytotoxicity against the multidrug-resistant cell lines; the ED50 values were as low as 0.0006-mu-g/ml. Incubation of MCF-7 Ad(r) cells with varying concentrations of compounds in the presence of Adriamycin demonstrated that none of the compounds tested interfered with Pgp function. Results obtained using HBEC in primary culture showed a wide range of chemosensitivities for a given drug against tissue taken from different patients, demonstrating the uniqueness of the response of different individuals to chemotherapy.},
	keywords = {BREAST CANCER, CELLS, chemotherapy, COLORIMETRIC ASSAY, GROWTH, INVITRO SCREENING, MARINE ORGANISMS, SPONGE, TUMOR},
	isbn = {0344-5704},
	url = {<Go to ISI>://A1992JG98900011},
	author = {Stingl, J. and Andersen, R. J. and Emerman, J. T.}
}
