@article {2682,
	title = {Construction of protected hydroxylated pyrrolidines using nitrogen-centered radical cyclizations},
	journal = {Chemical Communications},
	number = {38},
	year = {2009},
	note = {ISI Document Delivery No.: 498CXTimes Cited: 3Cited Reference Count: 41Zhai, Huimin Zlotorzynska, Maria Sammis, Glenn},
	pages = {5716-5718},
	type = {Article},
	abstract = {Nitrogen-centered radical cyclizations onto silyl enol ethers were utilized for the syntheses of protected polyhydroxylated pyrrolidines 2-hydroxymethyl-3-hydroxypyrrolidine and 1,4-dideoxy-1,4-imino-L-ribitol.},
	keywords = {1, 4-DIDEOXY-1, 4-IMINO-L-RIBITOL, ADDITIONS, AMINYL RADICALS, GENERATION, glycosidase, inhibitors, NATURAL OCCURRENCE, ring expansion, ROUTE, STRAIGHTFORWARD SYNTHESIS, THERAPEUTIC APPLICATIONS},
	isbn = {1359-7345},
	url = {<Go to ISI>://000270115300013},
	author = {Zhai, H. M. and Zlotorzynska, M. and Sammis, G.}
}
@article {2561,
	title = {Functional Cell-Based Screening and Saturation Transfer Double-Difference NMR Have Identified Haplosamate A as a Cannabinoid Receptor Agonist},
	journal = {Acs Chemical Biology},
	volume = {4},
	number = {2},
	year = {2009},
	note = {ISI Document Delivery No.: 410WNTimes Cited: 1Cited Reference Count: 19Pereira, Alban Pfeifer, Tom A. Grigliatti, Thomas A. Andersen, Raymond J.},
	month = {Feb},
	pages = {139-144},
	type = {Article},
	abstract = {A marine natural product extract library has been screened with a functional cell-based G-protein coupled receptor assay to find compounds capable of binding the human cannabinoid receptors CB1 and CB2. The methanol extract of the marine sponge Dasychalina fragilis collected in Papua New Guinea was active in the assay. Bioassay guided fractionation of the extract identified the phosphorylated sterol sulfate haplosamate A(1) as a cannabinoid receptor agonist. The high water solubility of haplosamate A(1) allowed exploration of its binding interactions with the human cannabinoid recepors in whole insect cells by means of saturation transfer double-difference NMR spectroscopy. This technique confirmed that haplosamate A(1) binds selectively to these receptors.},
	keywords = {DOCKING, ENDOCANNABINOID SYSTEM, inhibitors, INTEGRIN ALPHA(IIB)BETA(3), LIGAND-BINDING, PEPTIDE, PROTEIN, SPECTROSCOPY, STD-NMR},
	isbn = {1554-8929},
	url = {<Go to ISI>://000263609100008},
	author = {Pereira, A. and Pfeifer, T. A. and Grigliatti, T. A. and Andersen, R. J.}
}
@article {2385,
	title = {A Peterson avenue to 5-alkenyloxazoles},
	journal = {Tetrahedron Letters},
	volume = {50},
	number = {45},
	year = {2009},
	note = {ISI Document Delivery No.: 506HLTimes Cited: 3Cited Reference Count: 50Chau, Jaclyn Zhang, Jianmin Ciufolini, Marco A.},
	month = {Nov},
	pages = {6163-6165},
	type = {Article},
	abstract = {The TiCl4-promoted Peterson olefination of aldehydes with readily available 5-(trimethylsilyl)methyloxazoles furnishes 5-alkenyloxazoles (mostly E-isomers). (C) 2009 Elsevier Ltd. All rights reserved.},
	keywords = {CALYCULIN, CHEMISTRY, CONSTRUCTION, HETEROCYCLIC-DERIVATIVES, inhibitors, NATURAL-PRODUCTS, OXAZOLES, PHORBOXAZOLE, PSEUDOMONIC ACID, SIPHONAZOLE},
	isbn = {0040-4039},
	url = {<Go to ISI>://000270765700015},
	author = {Chau, J. and Zhang, J. M. and Ciufolini,Marco A.}
}
@article {1054,
	title = {Avrainvilloside, a 6-deoxy-6-aminoglucoglycerolipid from the green alga Avrainvillea nigricans},
	journal = {Journal of Natural Products},
	volume = {68},
	number = {9},
	year = {2005},
	note = {ISI Document Delivery No.: 968NTTimes Cited: 5Cited Reference Count: 13},
	month = {Sep},
	pages = {1428-1430},
	type = {Article},
	abstract = {Fractionation of the organic extract obtained from the Dominican green alga Avrainvillea nigricans led to the isolation of avrainvilloside (2), a new glycoglycerolipid bearing the extremely rare 6-deoxy-6-aminoglucose moiety. The structure of avrainvilloside has been established on the basis of spectroscopic data and methanolysis/GC-MS analysis.},
	keywords = {GLYCEROGLYCOLIPIDS, inhibitors},
	isbn = {0163-3864},
	url = {<Go to ISI>://000232169900027},
	author = {Andersen, R. J. and Taglialatela-Scafati, O.}
}
@article {1029,
	title = {Pachymoside A - A novel glycolipid isolated from the marine sponge Pachymatisma johnstonia},
	journal = {Canadian Journal of Chemistry-Revue Canadienne De Chimie},
	volume = {82},
	number = {2},
	year = {2004},
	note = {ISI Document Delivery No.: 802BHTimes Cited: 5Cited Reference Count: 21},
	month = {Feb},
	pages = {102-112},
	type = {Article},
	abstract = {Crude extracts of the North Sea marine sponge Pachymatisma johnstonia showed promising activity in a new assay for inhibitors of bacterial type III secretion. Bioassay-guided fractionation resulted in the isolation of the pachymosides, a new family of sponge glycolipids. A major part of the structural diversity in this family of glycolipids involves increasing degrees of acetylation and differing positions of acetylation on a common pachymoside glycolipid template. All of the metabolites with these variations in acetylation pattern were converted into the same peracetylpachymoside methyl ester (2) for purification and spectroscopic analysis. Pachymoside A (1) is the component of the mixture that has natural acetylation at the eight galactose hydroxyls and at the C-6 hydroxyls of glucose-B and glucose-D. Chemical degradation and transformation in conjunction with extensive analysis of 800 MHz NMR data was used to elucidate the structure of pachymoside A (1).},
	keywords = {BACTERIAL VIRULENCE, ENTEROPATHOGENIC ESCHERICHIA-COLI, glycolipid, GLYCOSPHINGOLIPIDS, HOST-CELLS, III SECRETION, inhibitors, marine sponge, NATURAL-PRODUCTS, Pachymatisma johnstonia, pachymoside, PLAKORTIS-SIMPLEX, PLAKOSIDE, PRENYLATED, RECEPTOR},
	isbn = {0008-4042},
	url = {<Go to ISI>://000220138500006},
	author = {Warabi, K. and Zimmerman, W. T. and Shen, J. K. and Gauthier, A. and Robertson, M. and Finlay, B. B. and Van Soest, R. and Andersen, R. J.}
}
@article {4540,
	title = {Papuamides A-D, HIV-inhibitory and cytotoxic depsipeptides from the sponges Theonella mirabilis and Theonella swinhoei collected in Papua New Guinea},
	journal = {Journal of the American Chemical Society},
	volume = {121},
	number = {25},
	year = {1999},
	note = {ISI Document Delivery No.: 212KXTimes Cited: 83Cited Reference Count: 32},
	month = {Jun},
	pages = {5899-5909},
	type = {Article},
	abstract = {The novel cyclic depsipeptides papuamides A (1), B (2), C (3), and D (4) have been isolated from Papua New Guinea collections of the sponges Theonella mirabilis and Theonella swinhoei. Their structures were determined by a combination of spectroscopic analysis and chemical degradation and derivatization studies. In addition to glycine, alanine, and threonine, these peptides contain a number of unusual amino acids including 3,4-dimethylglutamine, beta-methoxytyrosine, 3-methoxyalanine, and 2,3-diaminobutanoic acid or 2-amino-2-butenoic acid residues. Papuamides A-D (1-4) are also the first marine-derived peptides reported to contain 3-hydroxyleucine and homoproline residues. These peptides also contain a previously undescribed 2,3-dihydroxy-2,6,8-trimethyldeca-(4Z,6E)-dienoic acid moiety N-linked to a terminal glycine residue. Papuamides A (1) and B (2) inhibited the infection of human T-lymphoblastoid cells by HIV-1(RF) in vitro with an EC50 of approximately 4 ng/mL. Compound 1 was also cytotoxic against a panel of human cancer cell lines with a mean IC50 of 75 ng/mL.},
	keywords = {ACIDS, ANTIFUNGAL CYCLIC-PEPTIDES, CALLIPELTA, CYCLOTHEONAMIDES, ENANTIOMERICALLY PURE, GLYCOPEPTIDE, inhibitors, MARINE NATURAL-PRODUCTS, MOZAMBIQUE, POTENT THROMBIN INHIBITORS, SERINE-PROTEASE, SP},
	isbn = {0002-7863},
	url = {<Go to ISI>://000081216800007},
	author = {Ford, P. W. and Gustafson, K. R. and McKee, T. C. and Shigematsu, N. and Maurizi, L. K. and Pannell, L. K. and Williams, D. E. and De Silva, E. D. and Lassota, P. and Allen, T. M. and Van Soest, R. and Andersen, R. J. and Boyd, M. R.}
}
@article {4447,
	title = {Pre-steady state kinetic analysis of an enzymatic reaction monitored by time-resolved electrospray ionization mass spectrometry},
	journal = {Biochemistry},
	volume = {37},
	number = {21},
	year = {1998},
	note = {ISI Document Delivery No.: ZR717Times Cited: 73Cited Reference Count: 53},
	month = {May},
	pages = {7664-7669},
	type = {Article},
	abstract = {For the first time, the new technique of time-resolved electrospray ionization mass spectrometry (ESI-MS) has been used to accurately measure the pre-steady state kinetics of an enzymatic reaction by monitoring a transient enzyme intermediate. The enzyme used to illustrate this approach, Bacillus circulans xylanase, is a retaining glycosidase that hydrolyzes xylan or beta-xylobiosides through a double-displacement mechanism involving a covalent xylobiosyl-enzyme intermediate. A low steady state level of this intermediate formed during the hydrolysis of 2,5-dinitrophenyl beta-D-xylobioside was detected by time-resolved ESI-MS. The low concentration of this intermediate and its rate of formation did not permit pre-steady state kinetic analysis. By contrast, the covalent intermediate accumulates fully when the Tyr80Phe mutant hydrolyzes the same substrate. Using time-resolved ESI-MS, the pre-steady state kinetic parameters for the formation of the covalent intermediate in the mutant xylanase have been determined. The kinetic data are in agreement with those determined by monitoring the release of 2,5-dinitrophenol with stopped-flow W-vis spectroscopy. This demonstrates that time-resolved ESI-MS can be used to accurately monitor the pre-steady state kinetics of enzymatic reactions, with the advantage of identifying transient enzyme intermediates by their mass.},
	keywords = {ACTIVE-SITE NUCLEOPHILE, AMINO-ACID, BACILLUS-CIRCULANS XYLANASE, beta-glucosidase, CELLULASES, CYTOCHROME-C, GAS-PHASE, IDENTIFICATION, inhibitors, MECHANISMS},
	isbn = {0006-2960},
	url = {<Go to ISI>://000074006700002},
	author = {Zechel, D. L. and Konermann, L. and Withers, S. G. and Douglas, D. J.}
}
@article {3768,
	title = {A formal, enantiospecific synthesis of pseudoguaianolides},
	journal = {Tetrahedron},
	volume = {52},
	number = {18},
	year = {1996},
	note = {ISI Document Delivery No.: UH378Times Cited: 16Cited Reference Count: 73},
	month = {Apr},
	pages = {6307-6324},
	type = {Article},
	abstract = {The preparation of ketal-enone (3) and hydroxy-ketones (1a), (16), and (4a), from (-)-camphor (6) represents a formal enantiospecific synthesis of (+)-carpesiolin, (+)-confertin, (-)-damsin, (-)-helenalin, (+)-bigelovin, (+)-mexicanin I, and (+)-linifolin A. Copyright (C) 1996 Elsevier Science Ltd},
	keywords = {(+)-CONFERTIN, (+/-)-CONFERTIN, ANTI-TUMOR LACTONES, CAMPHOR DERIVATIVES, DL-HELENALIN, inhibitors, ROUTE, SESQUITERPENE LACTONES, STEROID-SYNTHESIS, SYSTEM},
	isbn = {0040-4020},
	url = {<Go to ISI>://A1996UH37800004},
	author = {Money, T. and Wong, M. K. C.}
}
@article {7321,
	title = {BINDING-ENERGY AND CATALYSIS - FLUORINATED AND DEOXYGENATED GLYCOSIDES AS MECHANISTIC PROBES OF ESCHERICHIA-COLI (LACZ) BETA-GALACTOSIDASE},
	journal = {Biochemical Journal},
	volume = {286},
	year = {1992},
	note = {ISI Document Delivery No.: JN815Times Cited: 86Cited Reference Count: 40Part 3},
	month = {Sep},
	pages = {721-727},
	type = {Article},
	abstract = {Kinetic parameters for the hydrolysis of a series of deoxy and deoxyfluoro analogues of 2{\textquoteright},4{\textquoteright}-dinitrophenyl beta-D-galactopyranoside by Escherichia coli (lacZ) beta-galactosidase have been determined and rates found to be two to nine orders of magnitude lower than that for the parent compound. These large rate reductions result primarily from the loss of transition-state binding interactions due to the replacement of sugar hydroxy groups, and such interactions are estimated to contribute at least 16.7 kJ (4 kcal).mol-1 to binding at the 3, 4 and 6 positions and more than 33.5 kJ (8 kcal).mol-1 at the 2 position. The existence of a linear free-energy relationship between log(k(cat.)/K(m)) for these compounds and the logarithm of the first-order rate constant for their spontaneous hydrolysis demonstrates that electronic effects are also important and provides direct evidence for oxocarbonium ion character in the enzymic transition state. A covalent intermediate which turns over only extremely slowly (t1/2 = 45 h) accumulates during hydrolysis of the 2-deoxyfluorogalactoside, and kinetic parameters for its formation have been determined. This intermediate is nonetheless catalytically competent, since it re-activates much more rapidly in the presence of the transglycosylation acceptors methanol or glucose, thereby providing support for the notion of a covalent intermediate during hydrolysis of the parent substrates.},
	keywords = {ALPHA-D-GLUCOPYRANOSYL, D-GLUCOPYRANOSYL PHOSPHATES, ENZYME, GLYCOGEN-PHOSPHORYLASE, HYDROLYSIS, inhibitors, OLIGOSACCHARIDE, SITE, SPECIFICITY, SUBSTRATE},
	isbn = {0264-6021},
	url = {<Go to ISI>://A1992JN81500010},
	author = {McCarter, J. D. and Adam,Michael J. and Withers, S. G.}
}
