@article {2360,
	title = {Metabolic abnormalities in fronto-striatal-thalamic white matter tracts in schizophrenia},
	journal = {Schizophrenia Research},
	volume = {109},
	number = {1-3},
	year = {2009},
	note = {ISI Document Delivery No.: 437VZTimes Cited: 3Cited Reference Count: 52Beasley, Clare L. Dwork, Andrew J. Rosoklija, Gorazd Mann, J. John Mancevski, Branislav Jakovski, Zlatko Davceva, Natasa Tait, Andrew R. Straus, Suzana K. Honer, William G.},
	month = {Apr},
	pages = {159-166},
	type = {Article},
	abstract = {{The anterior limb of the internal capsule (ALIC) is the major white matter tract providing reciprocal connections between the frontal cortex, striatum and thalamus. Mounting evidence suggests that this tract may be affected in schizophrenia, with brain imaging studies reporting reductions in white matter volume and density, changes in fractional anisotropy and reduced asymmetry. However, the molecular correlates of these deficits are currently unknown. The aim of this study was to identify alterations in protein and metabolite levels in the ALIC in schizophrenia. Samples were obtained post-mortem from individuals with schizophrenia (n = 15) and non-psychiatric controls (n = 13). Immunoreactivity for the myelin-associated protein myelin basic protein (MBP), and the axonal-associated proteins phosphorylated neurofilament and SNAP-25 was measured by enzyme-linked immunoadsorbent assay (ELISA). Metabolite concentrations were quantified by proton nuclear magnetic resonance (H-1 NMR) spectroscopy. Levels of myelin- or axonal-associated proteins did not differ between groups. Overall differences in metabolite concentrations were observed between the two groups (MANOVA F=2.685},
	keywords = {ANTERIOR CINGULATE CORTEX, Axon, BASAL GANGLIA, composition, CORPUS-CALLOSUM, EXPRESSION, fiber, HUMAN INTERNAL CAPSULE, Internal capsule, LACTATE, MENTAL-ILLNESS, METABOLITE, myelin, POLARIZED-LIGHT, POSTMORTEM BRAINS, PREFRONTAL CORTEX, SEVERE},
	isbn = {0920-9964},
	url = {<Go to ISI>://000265516300023},
	author = {Beasley, C. L. and Dwork, A. J. and Rosoklija, G. and Mann, J. J. and Mancevski, B. and Jakovski, Z. and Davceva, N. and Tait, A. R. and Straus, S. K. and Honer, W. G.}
}
@article {4659,
	title = {Measurement of some small-molecule and peptide neurotransmitters in-vitro using a fiber-optic probe with pulsed ultraviolet resonance Raman spectroscopy},
	journal = {Journal of Neuroscience Methods},
	volume = {92},
	number = {1-2},
	year = {1999},
	note = {ISI Document Delivery No.: 262ADTimes Cited: 13Cited Reference Count: 22},
	month = {Oct},
	pages = {15-24},
	type = {Article},
	abstract = {Many techniques have been developed to investigate the chemistry associated with brain activity. These techniques generally fall into two categories: fast techniques with species-limited sensitivity; and generally slower techniques with broader species sensitivity. Therefore, a need exists for a fast, minimally invasive technique that is sensitive to a wide array of biologically relevant compounds in order to measure chemical brain events in real time. The work presented here describes the development of a novel spectroscopic neurotransmitter probe for the rapid and simultaneous detection of a variety of neurotransmitters. A fiber-optic-linked Raman and tunable ultraviolet resonance Raman system was assembled with custom designed optical fiber probes. Using this system, the ultraviolet resonance Raman spectra of some small-molecule and peptide neurotransmitters were measured in-vitro with a fiber-optic probe and are reported here for the first time. The probe has furthermore been used to measure neurotransmitter secretions obtained from depolarized rat pheochromocytoma (PC12) cells. These results demonstrate the general utility of this approach which, due to the fiber-optic implementation, could potentially also be applied to in-vivo neurotransmitter determinations. (C) 1999 Elsevier Science B.V. All rights reserved.},
	keywords = {CELLS, fiber, neuropeptide, neurotransmitter, optical, resonance Raman spectroscopy},
	isbn = {0165-0270},
	url = {<Go to ISI>://000084042800003},
	author = {Schulze, H. G. and Greek, L. S. and Barbosa, C. J. and Blades, M. W. and Gorzalka, B. B. and Turner, R. F. B.}
}
@article {4659,
	title = {Measurement of some small-molecule and peptide neurotransmitters in-vitro using a fiber-optic probe with pulsed ultraviolet resonance Raman spectroscopy},
	journal = {Journal of Neuroscience Methods},
	volume = {92},
	number = {1-2},
	year = {1999},
	note = {ISI Document Delivery No.: 262ADTimes Cited: 13Cited Reference Count: 22},
	month = {Oct},
	pages = {15-24},
	type = {Article},
	abstract = {Many techniques have been developed to investigate the chemistry associated with brain activity. These techniques generally fall into two categories: fast techniques with species-limited sensitivity; and generally slower techniques with broader species sensitivity. Therefore, a need exists for a fast, minimally invasive technique that is sensitive to a wide array of biologically relevant compounds in order to measure chemical brain events in real time. The work presented here describes the development of a novel spectroscopic neurotransmitter probe for the rapid and simultaneous detection of a variety of neurotransmitters. A fiber-optic-linked Raman and tunable ultraviolet resonance Raman system was assembled with custom designed optical fiber probes. Using this system, the ultraviolet resonance Raman spectra of some small-molecule and peptide neurotransmitters were measured in-vitro with a fiber-optic probe and are reported here for the first time. The probe has furthermore been used to measure neurotransmitter secretions obtained from depolarized rat pheochromocytoma (PC12) cells. These results demonstrate the general utility of this approach which, due to the fiber-optic implementation, could potentially also be applied to in-vivo neurotransmitter determinations. (C) 1999 Elsevier Science B.V. All rights reserved.},
	keywords = {CELLS, fiber, neuropeptide, neurotransmitter, optical, resonance Raman spectroscopy},
	isbn = {0165-0270},
	url = {<Go to ISI>://000084042800003},
	author = {Schulze, H. G. and Greek, L. S. and Barbosa, C. J. and Blades, M. W. and Gorzalka, B. B. and Turner, R. F. B.}
}
