@article {1522, title = {Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific marine hydroid Garveia annulata}, journal = {Journal of Natural Products}, volume = {69}, number = {10}, year = {2006}, note = {ISI Document Delivery No.: 098ZQTimes Cited: 17Cited Reference Count: 20Pereira, Alban Vottero, Eduardo Roberge, Michel Mauk, A. Grant Andersen, Raymond J.}, month = {Oct}, pages = {1496-1499}, type = {Article}, abstract = {Crude extracts of the marine hydroid Garveia annulata show potent inhibition of indoleamine 2,3-dioxygenase (IDO). Fractionation of the extract led to the identification of the new polyketides annulin C (1), 2-hydroxygarveatin E (4), garveatin E (5), and garvin C (9). Annulins A (2), B (3), and C (1) were found to be submicromolar inhibitors of IDO.}, keywords = {CANCER, chemotherapy, ENZYME, HUMAN LENS, MECHANISM, METABOLITES, NUCLEAR CATARACT, REJECTION, TOLERANCE, TRYPTOPHAN DEGRADATION}, isbn = {0163-3864}, url = {://000241562700025}, author = {Pereira, A. and Vottero, E. and Roberge, M. and Mauk, A. G. and Andersen, R. J.} }