@article {2450,
	title = {Quantitative analysis of propofol in whole blood using capillary electrophoresis},
	journal = {Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences},
	volume = {877},
	number = {8-9},
	year = {2009},
	note = {ISI Document Delivery No.: 424NVTimes Cited: 2Cited Reference Count: 19Hui, Yu Raedschelders, Koen Zhang, Hong Ansley, David M. Chen, David D. Y.},
	month = {Mar},
	pages = {703-709},
	type = {Article},
	abstract = {We have developed a straightforward capillary electrophoresis method capable of quantifying clinically relevant propofol concentrations in whole blood from patients undergoing aortocoronary bypass grafting with cardiopulmonary bypass. The method utilizes 400 mu L of whole blood and is capable of detecting propofol in the ng/mL range. Factors affecting reproducibility and reliability of analytical results for clinically relevant samples are discussed. The method was used to evaluate propofol concentrations in blood samples from 30 patients. The distribution in the whole blood concentration achieved in patients advocates the need for target-achieved monitoring techniques. (C) 2009 Elsevier B.V. All rights reserved.},
	keywords = {Aortocoronary bypass, BIOPHARMACEUTICAL INDUSTRY, BREATH, capillary electrophoresis, Cardiopulmonary bypass, CHROMATOGRAPHY-MASS-SPECTROMETRY, grafting, HUMAN, Method development, PLASMA, POPULATION, Propofol, Whole blood},
	isbn = {1570-0232},
	url = {<Go to ISI>://000264574300006},
	author = {Hui, Y. and Raedschelders, K. and Zhang, H. and Ansley, D. M. and Chen, D. D. Y.}
}
@article {2350,
	title = {Rationale, design and baseline characteristics of the PROJECT II study: PROpofol CardioproTECTion for Type II diabetics A randomized, controlled trial of high-dose propofol versus isoflurane preconditioning in patients undergoing on-pump coronary artery b},
	journal = {Contemporary Clinical Trials},
	volume = {30},
	number = {4},
	year = {2009},
	note = {ISI Document Delivery No.: 456NPTimes Cited: 1Cited Reference Count: 23Ansley, David M. Raedschelders, Koen Chen, David D. Y. Choi, Peter T.},
	month = {Jul},
	pages = {380-385},
	type = {Article},
	abstract = {Diabetes mellitus is a leading cause of death globally and results in significant morbidity and mortality following surgery. After cardiac surgery, diabetic patients are especially at risk for low cardiac output syndrome, which can quadruple the risk for postoperative death. Attempts to prevent low cardiac output syndrome have focused on increasing myocardial tolerance to ischemia (preconditioning), which involves the myocardial mitochondrial ATP-regulated K-ATP channel. G-protein initiation, nitric oxide synthase, and protein kinase C. Unfortunately, the signal transduction pathways required for preconditioning are corrupted in diabetes. Effective antioxidant intervention during ischemia-reperfusion appears important for preserving myocardial function: thus, alleviating oxidant-mediated post-ischemic injury by increasing antioxidant defenses (cardioprotection) is an alternative to preconditioning. Our previous work suggests that propofol(2,6-diisopropylphenol), an intravenous anesthetic with antioxidant potential, may confer cardioprotection. In this paper, we describe the rationale and methodology of the Pro-TECT II Study, a Phase II randomized controlled trial designed to explore the relationships of biomarkers of oxidative or nitrosative stress in diabetes, to determine the effect of propofol cardioprotection to counteract these effects in patients undergoing elective primary coronary bypass graft surgery with cardiopulmonary bypass, and to provide feasibility and sample size data needed to conduct Phase III trials. (C) 2009 Elsevier Inc. All rights reserved.},
	keywords = {15-F-2T-ISOPROSTANE FORMATION, antioxidant, apoptosis, CAPACITY, Cardiopulmonary bypass, Diabetes mellitus, EXPRESSION, F2-isoprostanes, HYPERGLYCEMIA, INJURY, MORTALITY, MYOCARDIAL-INFARCTION, Nitric oxide synthase type III, PREDICTORS, Propofol, SHORT-TERM},
	isbn = {1551-7144},
	url = {<Go to ISI>://000266853900014},
	author = {Ansley, D. M. and Raedschelders, K. and Chen, D. D. Y. and Choi, P. T.}
}
