@article {MacLennan201879,
	title = {Capillary electrophoresis-mass spectrometry for targeted and untargeted analysis of the sub-5 kDa urine metabolome of patients with prostate or bladder cancer: A feasibility study},
	journal = {Journal of Chromatography B},
	volume = {1074{\textendash}1075},
	year = {2018},
	pages = {79 - 85},
	abstract = {Abstract Targeted and untargeted analyses of the sub-5 kDa urine metabolome of genitourinary cancer patients (prostate and/or bladder) were performed without chemical derivatization using capillary electrophoresis-electrospray ionization-mass spectrometry (CE-ESI-MS). For targeted analysis, endogenous levels of sarcosine and 5 other amino acid metabolites implicated in the progression of prostate cancer were quantified in four patients and in a pooled urine sample from healthy volunteers. An untargeted analysis (m/z 50 to 850) of patient urine was performed using the same CE-ESI-MS system identifying over 400 distinct molecular features per patient. All patient urine samples were collected at prostatectomy/cystectomy via catheter. Patient urine samples were filtered by centrifugation, with endogenous sarcosine enriched by solid-phase extraction, and the processed samples loaded onto CE-ESI-MS for analysis. Diagnostic information, digital pathological slides, and tissue samples were collected and stored in a comprehensive biobanking database. The introduction of urine sample collection into the surgery workflow was facile and is a promising strategy for addressing the translational research challenge of moving smoothly from {\textquotedblleft}chromatogram to nomogram{\textquotedblright}.},
	keywords = {amino acids},
	issn = {1570-0232},
	doi = {https://doi.org/10.1016/j.jchromb.2018.01.007},
	url = {https://www.sciencedirect.com/science/article/pii/S1570023217317051},
	author = {Matthew S. MacLennan and Miranda G.M. Kok and Laiel Soliman and Alan So and Antonio Hurtado-Coll and David D.Y. Chen}
}
@article {11431,
	title = {Highly enantioselective, catalytic conjugate addition of cyanide to alpha,beta-unsaturated imides.},
	journal = {Journal of the American Chemical Society},
	volume = {125},
	year = {2003},
	month = {2003 Apr 16},
	pages = {4442-3},
	abstract = {(Salen)Al-Cl complex 1a catalyzes the asymmetric conjugate addition of hydrogen cyanide to alpha,beta-unsaturated imides in high yields and enantioselectivities. The cyanide adducts can readily be converted into a variety of useful chiral building blocks, including alpha-substituted-beta-amino acids and beta-substituted-gamma-aminobutyric acids. Mechanistic data obtained thus far point to a cooperative bimetallic mechanism for nucleophile and electrophile activation.},
	keywords = {ALKENES, amino acids, CATALYSIS, CYANIDES, gamma-Aminobutyric Acid, Imides, Stereoisomerism},
	issn = {0002-7863},
	author = {Sammis, G. M. and Jacobsen, Eric N.}
}
@article {443,
	title = {Univalent salts as modifiers in micellar capillary electrophoresis},
	journal = {Electrophoresis},
	volume = {23},
	number = {12},
	year = {2002},
	note = {ISI Document Delivery No.: 573XDTimes Cited: 11Cited Reference Count: 23},
	month = {Jun},
	pages = {1912-1920},
	type = {Article},
	abstract = {The influence of three univalent salts (LiCl, and RbCl) on the separation of amino acids labelled with 3-(4-carboxybenzoyl)-quinoline-2-carboxaldehyde (CBQCA) in micellar capillary electrophoresis has been studied. Capacity factors for a series of eight CBQCA-labelled amino acids in a sodium dodecyl sulfate (SDS) micellar system containing different concentrations of salt were measured and were found to be related to both the hydrodynamic radius of the salt counter-ion (Li+, Na+, Rb+) and the relative hydrophobicity of the amino acid. Affinities of the analytes for the micelles were generally observed to decrease as the salt concentration in the background electrolyte was increased from 10 to 50 mM. This decrease in affinity was greatest in the presence of the salt counter-ion with the smallest hydrodynamic radius and is primarily due to an increased resistance to mass transfer. Furthermore, interaction of hydrophobic analytes with the micelles is greater than that of hydrophilic analytes at all salt concentrations due to the greater strength of the hydrophobic interactions and this effect is also enhanced in the presence of a smaller counter-ion. No negative effects due to Joule heating or electromigrative dispersion were observed for low to moderate concentrations of salt, which suggests that the use of simple univalent salts to modify analyte/micelle affinities can be a practical method for improving the separation of complex mixtures.},
	keywords = {amino acids, AMMONIUM-SALTS, COUNTER-ION, EFFICIENCY, ELECTROKINETIC CHROMATOGRAPHY, FLUORESCENCE, micellar capillary electrophoresis, MIGRATION BEHAVIOR, modifiers, RESOLUTION, salt, SDS, SELECTIVITY, SEPARATION},
	isbn = {0173-0835},
	url = {<Go to ISI>://000176857000019},
	author = {McLaren, D. G. and Boulat, O. and Chen, D. D. Y.}
}
@article {5207,
	title = {Effects of pressure and temperature on the solubility of monosodium L-glutamate monohydrate in water},
	journal = {High Pressure Research},
	volume = {21},
	number = {2},
	year = {2001},
	note = {ISI Document Delivery No.: 572UGTimes Cited: 4Cited Reference Count: 21},
	pages = {93-104},
	type = {Article},
	abstract = {The solubility of monosodium L-glutamate monohydrate (MSG.H2O) in water was measured at pressures in the range of 0.10-300 MPa and 298.15 K. The density of MSG solution at high concentrations and heat of solution at saturated concentration were also measured at atmospheric pressure. The solubility, m,, increased with increasing pressure and the pressure coefficient, theta(p) [equivalent to(partial derivative ln m(s)/partial derivativep)(T)], at 0. 10 MPa was (2.0 +/- 0.1) x 10(-10) Pa-1. It agrees well with (2.1 +/- 0.2) x 10(-10) Pa-1 thermodynamically estimated using the partial molar volume, the activity coefficient of the solute in solution, and the molar volume of the crystal. The excellent agreement at 0.10 MPa gives us confidence in the solubility data at higher pressures. The heat of solution data and other pertinent values were used to calculate the temperature coefficient of solubility, theta(T) [equivalent to(partial derivative ln ms/partial derivative(1/T))(p)], by a thermodynamic equality. The resulting theta(T) compares well with the data directly measured by Ogawa.},
	keywords = {25-DEGREES-C, amino acids, CRYSTAL, density, heat of, HIGH-PRESSURE, molar volume, SOLUBILITY, SOLUTION},
	isbn = {0895-7959},
	url = {<Go to ISI>://000176792900003},
	author = {Suzuki, Y. and Matsuo, H. and Koga,Yoshikata and Mukae, K. and Kawakita, T. and Sawamura, S.}
}
@article {5019,
	title = {Separation of free amino acids in human plasma by capillary electrophoresis with laser induced fluorescence: potential for emergency diagnosis of inborn errors of metabolism},
	journal = {Journal of Chromatography B},
	volume = {754},
	number = {1},
	year = {2001},
	note = {ISI Document Delivery No.: 418PQTimes Cited: 44Cited Reference Count: 28},
	month = {Apr},
	pages = {217-228},
	type = {Article},
	abstract = {Free amino acids (AAs) in human plasma are derivatized with 3-(4-carboxybenzoyl)quinoline -2-carboxaldehyde (CBQCA) and analyzed by capillary electrophoresis (CE) with laser induced fluorescence (LIF) detection. The labeling procedure is significantly improved over results reported previously. Derivatization can be completed in 40 min, with concentrations as low as 4x10(-8) M successfully labeled in favourable cases. Twenty-nine AAs (including 2 internal standards) are identified and can be reproducibly separated in 70 min. Migration time RSD values for 23 of these AAs were calculated and found in the range from 0.5 to 4\%. The rapid derivatization procedure and the resolution obtained in the separation are sufficient for a semi-quantitative, emergency diagnosis of several inborn errors of metabolism (IEM). Amino acid profiles for both normal donor plasma samples and plasma samples of patients suffering from phenylketonuria, tyrosinemia, maple syrup urinary disease, hyperornithinemia. and citrullinemia are studied. (C) 2001 Elsevier Science B.V. All rights reserved.},
	keywords = {amino acids, CARNITINE, CHROMATOGRAPHY, inborn errors, urine, ZONE ELECTROPHORESIS},
	isbn = {0378-4347},
	url = {<Go to ISI>://000167900900026},
	author = {Boulat, O. and McLaren, D. G. and Arriaga, E. A. and Chen, D. D. Y.}
}
