@article {YAN2020122216,
	title = {Enantioselective analysis in complex matrices using capillary electrophoresis-mass spectrometry: A case study of the botanical drug Corydalis Rhizoma},
	journal = {Journal of Chromatography B},
	volume = {1152},
	year = {2020},
	month = {06/2020},
	pages = {122216},
	abstract = {<p>Enantioselective analysis is critically important in the pharmaceutical and agricultural industries. However, most of the methods reported were developed for the analysis of pure racemates acquired from chemical synthesis or purification. Direct analysis of chiral enantiomers in complex matrices has rarely been reported. This work demonstrated capillary electrophoresis-mass spectrometry (CE-MS) for the enantioselective analysis of botanical drugs for the first time, using a widely used botanical drug, Corydalis Rhizoma, as an example. The method was used for the simultaneous enantioselective analysis of dl-tetrahydropalmatine and (RS)-tetrahydroberberine (canadine) in Corydalis Rhizoma extract. Using (2-hydroxypropyl)-β-cyclodextrin as the chiral selector, a partial filling technique was used to avoid signal suppression and contamination of the MS detector. Post column organic modifier was used to assist with ionization in the flow through microvial CE-MS interface, therefore, organic solvents was not used in the background electrolyte. The completely aqueous background electrolyte contributed to better chiral separations. The CE-MS method established here can directly determine the analytes in their complex matrix without any pre-purification steps, while also offering high sensitivity and low operational costs (including sample, chiral selector and solvent). In the method validation process, good linearity (r \&gt; 0.993), sensitivity and accuracy (recoveries within 89.1\&ndash;110.0\%) were demonstrated. The CE-MS technique was shown to be able to provide good selectivity for the simultaneous chiral separation of multiple pairs of enantiomers in complex matrices.</p>},
	keywords = {Botanical drug, CHIRAL, Corydalis Rhizoma, Electrophoresis-mass spectrometry, Tetrahydroberberine, Tetrahydropalmatine},
	issn = {1570-0232},
	doi = {https://doi.org/10.1016/j.jchromb.2020.122216},
	url = {http://www.sciencedirect.com/science/article/pii/S1570023220306401},
	author = {Binjun Yan and Zi-Ao Huang and Noorfatimah Yahaya and DDY Chen}
}
@article {4317,
	title = {The effects of a mixture of charged and neutral additives on analyte migration behavior in capillary electrophoresis},
	journal = {Electrophoresis},
	volume = {19},
	number = {3},
	year = {1998},
	note = {ISI Document Delivery No.: ZD713Times Cited: 14Cited Reference Count: 45},
	month = {Mar},
	pages = {388-396},
	type = {Article},
	abstract = {Multicomponent additives, such as derivatized cyclodextrins with various degrees of substitution, can be considered single-component additives as long as the fraction of each component remains constant. In this paper, equations are derived describing the effect of such additives on the migration behavior of analytes. These equations are used in the study of capillary electrophoresis (CE) systems with differentially charged cyclodextrins as additives. For weakly acidic analytes, the binding with highly negatively charged sulfobutyl ether beta-cyclodextrin (SBE-beta-CD) increases their negative electrophoretic mobility, while the binding with neutral hydroxypropyl-beta-cyclodextrin (HP-beta-CD) decreases their negative mobility. By obtaining the equilibrium constants and mobilities for each additive with each analyte (in this case, phenol, 2-naphthol and 1-naphthol), the migration behavior of these analytes in CE systems is quantitatively predicted at various concentrations of mixtures of the two additives. The properties of the contour lines in the binding isotherm surfaces of such CE systems are discussed.},
	keywords = {ANALYTE, ASPECTS, BETA-CYCLODEXTRIN, CHIRAL, ELECTROPHORESIS, MICELLAR ELECTROKINETIC CHROMATOGRAPHY, MIGRATION BEHAVIOR, MOBILE PHASES, multicomponent additives, RESOLUTION, SELECTIVITY, SEPARATION, separation theory, STATIONARY PHASE, THEORETICAL, TIOCONAZOLE ENANTIOMERS, two-additive capillary, ZONE ELECTROPHORESIS},
	isbn = {0173-0835},
	url = {<Go to ISI>://000072716000004},
	author = {Kranack, A. R. and Bowser, M. T. and Britz-McKibbin, P. and Chen, D. D. Y.}
}
@article {7265,
	title = {COORDINATION CHEMISTRY OF 2-(2{\textquoteright}-HYDROXYPHENYL)-2-OXAZOLINES WITH ALUMINUM, GALLIUM, AND INDIUM - 1ST TRIS(LIGAND)METAL(III) COMPLEXES OF THIS NATURALLY-OCCURRING BINDING GROUP},
	journal = {Inorganic Chemistry},
	volume = {31},
	number = {26},
	year = {1992},
	note = {ISI Document Delivery No.: KE754Times Cited: 62Cited Reference Count: 44},
	month = {Dec},
	pages = {5408-5416},
	type = {Article},
	abstract = {{A series of tris(ligand)metal(III) complexes of group 13 metals (Al, Ga, In) with 2-(2{\textquoteright}-hydroxyphenyl)-2-oxazoline (Hoz), 2-(5{\textquoteright}-bromo-2{\textquoteright}-hydroxyphenyl)-2-oxazoline (HBroz), 2-(2{\textquoteright}-hydroxy-3{\textquoteright}-methylphenyl)-2-oxazoline(Hmoz), 2-(2{\textquoteright}-hydroxy-3{\textquoteright}-allylphenyl)-2-oxazoline (Haloz) have been prepared. These compounds have been studied by a variety of techniques including variable-temperature NMR (H-1 and Al-27) and single-crystal X-ray diffraction. The M(OZ)3-CH3OH complexes (M = Al, Ga, In) are isomorphous and isostructural. Crystallographic data for C28H28MN3O7: monoclinic},
	keywords = {CHIRAL, CRYSTAL-STRUCTURE, ENTEROBACTIN, INTRAMOLECULAR REARRANGEMENT REACTIONS, ISOMERIZATION, KINETICS, LIGANDS, MICROBIAL IRON TRANSPORT, PROBABLE MECHANISM, SIDEROPHORES, TRIS-CHELATE COMPLEXES},
	isbn = {0020-1669},
	url = {<Go to ISI>://A1992KE75400016},
	author = {Hoveyda, H. R. and Karunaratne, V. and Rettig, S. J. and Orvig, Chris}
}
