@article {doi:10.1002/anie.201709532,
	title = {An Eighteen-Membered Macrocyclic Ligand for Actinium-225 Targeted Alpha Therapy},
	journal = {Angewandte Chemie International Edition},
	volume = {56},
	number = {46},
	year = {2017},
	pages = {14712-14717},
	abstract = {Abstract The 18-membered macrocycle H2macropa was investigated for 225Ac chelation in targeted alpha therapy (TAT). Radiolabeling studies showed that macropa, at submicromolar concentration, complexed all 225Ac (26 kBq) in 5 min at RT. [225Ac(macropa)]+ remained intact over 7 to 8 days when challenged with either excess La3+ ions or human serum, and did not accumulate in any organ after 5 h in healthy mice. A bifunctional analogue, macropa-NCS, was conjugated to trastuzumab as well as to the prostate-specific membrane antigen-targeting compound RPS-070. Both constructs rapidly radiolabeled 225Ac in just minutes at RT, and macropa-Tmab retained >99 \% of its 225Ac in human serum after 7 days. In LNCaP xenograft mice, 225Ac-macropa-RPS-070 was selectively targeted to tumors and did not release free 225Ac over 96 h. These findings establish macropa to be a highly promising ligand for 225Ac chelation that will facilitate the clinical development of 225Ac TAT for the treatment of soft-tissue metastases.},
	keywords = {actinium, CANCER, Chelates, macrocycles, RADIOPHARMACEUTICALS},
	doi = {10.1002/anie.201709532},
	url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201709532},
	author = {Thiele, Nikki A. and Brown, Victoria and Kelly, James M. and Amor-Coarasa, Alejandro and Jermilova, Una and MacMillan, Samantha N. and Nikolopoulou, Anastasia and Ponnala, Shashikanth and Ramogida, Caterina F. and Robertson, Andrew K. H. and Rodr{\'\i}guez-Rodr{\'\i}guez, Cristina and Schaffer, Paul and Williams Jr., Clarence and Babich, John W. and Radchenko, Valery and Wilson, Justin J.}
}
@article {WILSON2015428,
	title = {Evaluation of nitrogen-rich macrocyclic ligands for the chelation of therapeutic bismuth radioisotopes},
	journal = {Nuclear Medicine and Biology},
	volume = {42},
	number = {5},
	year = {2015},
	pages = {428 - 438},
	abstract = {Introduction The use of α-emitting isotopes for radionuclide therapy is a promising treatment strategy for small micro-metastatic disease. The radioisotope 213Bi is a nuclide that has found substantial use for targeted α-therapy (TAT). The relatively unexplored aqueous chemistry of Bi3+, however, hinders the development of bifunctional chelating agents that can successfully deliver these Bi radioisotopes to the tumor cells. Here, a novel series of nitrogen-rich macrocyclic ligands is explored for their potential use as Bi-selective chelating agents. Methods The ligands, 1,4,7,10-tetrakis(pyridin-2-ylmethyl)-1,4,7,10-tetraazacyclododecane (Lpy), 1,4,7,10-tetrakis(3-pyridazylmethyl)-1,4,7,10-tetraazacyclododecane (Lpyd), 1,4,7,10-tetrakis(4-pyrimidylmethyl)-1,4,7,10-tetraazacyclododecane (Lpyr), and 1,4,7,10-tetrakis(2-pyrazinylmethyl)-1,4,7,10-tetraazacyclododecane (Lpz), were prepared by a previously reported method and investigated here for their abilities to bind Bi radioisotopes. The commercially available and commonly used ligands 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and N-[(R)-2-amino-3-(p-isothiocyanato-phenyl)propyl]-trans-(S,S)- cyclohexane-1,2-diamine-N,N,N{\textquoteright},N",N"-pentaacetic acid (CHX-A''-DTPA) were also explored for comparative purposes. Radio-thin-layer chromatography (TLC) was used to measure the binding kinetics and stabilities of the complexes formed. The long-lived isotope, 207Bi (t1/2=32years), was used for these studies. Density functional theory (DFT) calculations were also employed to probe the ligand interactions with Bi3+ and the generator parent ion Ac3+. Results In contrast to DOTA and CHX-A''-DTPA, these nitrogen-rich macrocycles selectively chelate Bi3+ in the presence of the parent isotope Ac3+. Among the four tested, Lpy was found to exhibit optimal Bi3+-binding kinetics and complex stability. Lpy complexes Bi3+ more rapidly than DOTA, yet the resulting complexes are of similar stability. DFT calculations corroborate the experimentally observed selectivity of these ligands for Bi3+ over Ac3+. Conclusion Taken together, these data implicate Lpy as a valuable chelating agent for the delivery of 213Bi. Its selectivity for Bi3+ and rapid and stable labeling properties warrant further investigation and biological studies.},
	keywords = {Actinium-225, Bismuth-213, macrocycles, Radio-thin-layer chromatography, radiolabeling, Targeted α-therapy},
	issn = {0969-8051},
	doi = {https://doi.org/10.1016/j.nucmedbio.2014.12.007},
	url = {http://www.sciencedirect.com/science/article/pii/S0969805114005721},
	author = {Justin J. Wilson and Maryline Ferrier and Valery Radchenko and Joel R. Maassen and Jonathan W. Engle and Enrique R. Batista and Richard L. Martin and Francois M. Nortier and Michael E. Fassbender and Kevin D. John and Eva R. Birnbaum}
}
@article {2599,
	title = {Linear fully conjugated meso-aryl pentapyrrins},
	journal = {Tetrahedron Letters},
	volume = {50},
	number = {49},
	year = {2009},
	note = {ISI Document Delivery No.: 517HDTimes Cited: 0Cited Reference Count: 34Shin, Ji-Young Hepperle, Steven S. Dolphin, David},
	month = {Dec},
	pages = {6909-6912},
	type = {Article},
	abstract = {A meso-2,6-dichlorophenyl pentapyrrin was prepared using a modified method for dipyrrane synthesis followed by simple DDQ oxidation. The fully conjugated structures formed via redox inter-conversions were studied using crystallographic as well as observed and calculated spectral data. (C) 2009 Elsevier Ltd. All rights reserved.},
	keywords = {ANISOTROPIC DIELECTRICS, AROMATICITY, BASIS-SET, DENSITY-FUNCTIONAL THEORY, EXPANDED, IMPLEMENTATION, macrocycles, MESOSUBSTITUTED DIPYRROMETHANES, MOLECULAR-ORBITAL METHODS, porphyrins, TRIPYRRANE},
	isbn = {0040-4039},
	url = {<Go to ISI>://000271603000047},
	author = {Shin, J. Y. and Hepperle, S. S. and Dolphin, D.}
}
@article {2197,
	title = {trans-Disubstituted diamido/diamine cyclam zirconium complexes},
	journal = {Inorganic Chemistry Communications},
	volume = {11},
	number = {10},
	year = {2008},
	note = {ISI Document Delivery No.: 367KCTimes Cited: 6Cited Reference Count: 24Munha, Rui F. Alves, Luis G. Maulide, Nuno Duarte, M. Teresa Marko, Istvan E. Fryzuk, Michael D. Martins, Ana M.},
	month = {Oct},
	pages = {1174-1176},
	type = {Article},
	abstract = {The reaction of H-2[1,8-dibenzyl-1,4,8,11-tetraazacyclotetradecanel (H(2)Bn(2)CYclam) with 2 equiv of LiBu gives Li(2)Bn(2)Cyclam(L)2 (L = Et2O or THF) that reacts with ZrCl4(THF)(2) to afford (Bn(2)Cyclam)ZrCl2 in 40\% yield. Alternatively (Bn(2)Cyclam)ZrCl2 may be obtained via ZrCl2(CH2SiMe3)(2)(Et2O)(2) in a significantly higher yield (87\%), avoiding the lithiation of H(2)Bn(2)Cyclam. The syntheses of other H-2*Bn(2)CYClaM ligand precursors (*Bn = 3,5-dimethylbenzyl and 3,5-di(tert-butyl)benzyl) and the corresponding Zr derivatives ({3,5-Me2Bn}(2)-Cyclam)ZrCl2 and ({3,5-(Bu2Bn)-Bu-t}(2)-Cyclam)ZrCl2 are also reported. Results on preliminary tests of E-caprolactone and ethylene polymerisation reactions are presented. (C) 2008 Elsevier B.V. All rights reserved.},
	keywords = {amido ligands, CATALYSTS, CHEMISTRY, CONTAIN, Cyclam, epsilon-Caprolactone polymerisation, ETHYLENE, HAFNIUM COMPLEXES, LIGANDS, macrocycles, OLEFIN POLYMERIZATION, polymerisation, Tetraazamacrocycles, TITANIUM COMPLEXES, ZIRCONIUM},
	isbn = {1387-7003},
	url = {<Go to ISI>://000260549900019},
	author = {Munha, R. F. and Alves, L. G. and Maulide, N. and Duarte, M. T. and Marko, I. E. and Fryzuk,Michael D. and Martins, A. M.}
}
@article {617,
	title = {Dinuclear organometallic dinitrogen complexes of niobium},
	journal = {Inorganica Chimica Acta},
	volume = {345},
	year = {2003},
	note = {ISI Document Delivery No.: 653EUTimes Cited: 4Cited Reference Count: 30},
	month = {Mar},
	pages = {53-62},
	type = {Article},
	abstract = {{The niobium(III) chloride precursors (R)[P2N2]NbCl stabilized by the bis-(amidophosphine) macrocycle (where (R)[P2N2] RP(CH2SiMe2NSiMe2CH2)(2)PR},
	keywords = {ACTIVATION, amidophosphine ligands, AZOBENZENE, CLEAVAGE, CRYSTAL-STRUCTURE, CRYSTALLOGRAPHY, DINITROGEN COMPLEXES, END-ON, FIXATION, fluxionality, macrocycle, macrocycles, N-2, NIOBIUM, NITRIDE, SIDE-ON},
	isbn = {0020-1693},
	url = {<Go to ISI>://000181422900008},
	author = {Fryzuk,Michael D. and Kozak, C. M. and Patrick, B. O.}
}
@article {5034,
	title = {A highly efficient preparation of N-confused cyclodecapyrroles},
	journal = {Tetrahedron Letters},
	volume = {42},
	number = {19},
	year = {2001},
	note = {ISI Document Delivery No.: 427KUTimes Cited: 4Cited Reference Count: 33},
	month = {May},
	pages = {3263-3265},
	type = {Article},
	abstract = {Cyclodecapyrroles, potential novel host systems, were synthesized in 78-88\% yields by condensation of tripyrrane dialdehyde with bis(5-carboxyl-2,4-dimethyl-pyrrole-3-yl)-methane, ethane, and -propane in the presence of HBr and TFA. (C) 2001 Elsevier Science Ltd. All rights reserved.},
	keywords = {3, 3 {\textquoteright}-dipyrromethane, ANION SENSORS, CALIXPYRROLES, CYCLOOCTAPYRROLES, cyclopolypyrrole, EXPANDED PORPHYRINS, HOST, macrocycle, macrocycles, METAL-COMPLEXES, TRIPYRRANE},
	isbn = {0040-4039},
	url = {<Go to ISI>://000168404000006},
	author = {Chen, Q. Q. and Dolphin, D.}
}
@article {4214,
	title = {Novel and improved syntheses of 5,15-diphenylporphyrin and its dipyrrolic precursors},
	journal = {Journal of Porphyrins and Phthalocyanines},
	volume = {2},
	number = {6},
	year = {1998},
	note = {ISI Document Delivery No.: 209DJTimes Cited: 53Cited Reference Count: 66},
	month = {Nov-Dec},
	pages = {455-465},
	type = {Article},
	abstract = {Optimized syntheses of 5,15-diphenylporphyrin (DPP, 1) and its dipynolic precursors are described. A novel procedure for the synthesis of dipyrromethane (2), prepared by hydrodesulfurization of the corresponding di-2-pyrrolylthione (8), is presented, as well as an improved method to isolate large quantities of 5-phenyldipyrromethane (4), prepared by the acid-catalysed condensation of pyrrole with benzaldehyde. These dipyrromethanes are key reagents in two high-yield (2+2)-type syntheses of DPP. 5-Phenyldipyrromethane was formylated to provide 1-formyl- (11) and 1,9-diformyl-5-phenyldipyrromethane (12), and reduction of 11 provided the corresponding hydroxymethyl compound 13, These compounds (11-13), however, were much less efficient precursors to DPP. Two polypyrrolic compounds, 1,1,2,2-dipyrrolylethane (9) and 5,10-diphenyltripyrrane (10), potentially useful for the synthesis of porphyrinic macrocycles, were isolated as side-products during the dipyrromethane and 5-phenyldipyrromethane syntheses. (C) 1998 John Wiley \& Sons, Ltd.},
	keywords = {1, 10-diphenyltripyrrane, 2, 2+2 synthesis, 2-tetrapyrrolylethane, 5, 5-phenyldipyrromethane, ARYLPORPHYRINS, BIPHENYL, CHEMISTRY, COMPLEXES, dipyrromethane, macrocycles, MESO, meso-diphenylporphyrin synthesis, MESOSUBSTITUTED PORPHYRINS, METALLOPORPHYRINS, STEPWISE SYNTHESES, SUBSTITUTED PORPHYRIN},
	isbn = {1088-4246},
	url = {<Go to ISI>://000081032700001},
	author = {Bruckner, C. and Posakony, J. J. and Johnson, C. K. and Boyle, R. W. and James, Brian R. and Dolphin, D.}
}
@article {4212,
	title = {A water-soluble tetraethylsulfonate derivative of 2-methylresorcinarene as an additive for capillary electrophoresis},
	journal = {Analytical Chemistry},
	volume = {70},
	number = {5},
	year = {1998},
	note = {ISI Document Delivery No.: ZB216Times Cited: 12Cited Reference Count: 25},
	month = {Mar},
	pages = {907-912},
	type = {Article},
	abstract = {A water-soluble tetraethylsulfonate derivative of 2-methylresorcinarene (TESMR), an aromatic-based, bowl-shaped macrocycle, was used as an additive in capillary electrophoresis. Several phenol derivatives are used as analytes to demonstrate the effect of this highly charged additive, TESMR is observed to interact differently with a mixture of positional isomers and other types of phenol derivatives, A comparative study of separations with two charged additives, TESMR and sulfobutyl ether-beta-cyclodextrin (SBE-beta-CD), provided insight into the selectivity exhibited by these additives. The influence of buffer pH, ionic strength, and organic modifier content on separation and peak shape is investigated, Peak asymmetry caused by the use of highly charged additives at lower pH is minimized by the addition of small amounts of a polar aprotic organic solvent to the run buffer. The effects of mixing a charged additive with a neutral additive are also discussed.},
	keywords = {AROMATIC CAVITY, CHROMATOGRAPHY, ELECTROKINETIC, ETHER-BETA-CYCLODEXTRIN, ISOMERS, macrocycles, RESOLUTION, RESORCINOL CYCLIC TETRAMER, SEPARATION, ZONE ELECTROPHORESIS},
	isbn = {0003-2700},
	url = {<Go to ISI>://000072448400021},
	author = {Britr-McKibbin, P. and Chen, D. D. Y.}
}
@article {3293,
	title = {CHARACTERIZATION OF DECAMETHYL AND ETHOXYCARBONYL PENTAPHYRINS},
	journal = {Heterocycles},
	volume = {41},
	number = {11},
	year = {1995},
	note = {ISI Document Delivery No.: TF562Times Cited: 5Cited Reference Count: 23},
	month = {Nov},
	pages = {2553-2564},
	type = {Article},
	abstract = {The syntheses of decamethyl- and ethoxycarbonyl-pentaphyrins are described. Their spectroscopic characterizations are presented in comparison with the permethyl derivatives of porphyrin, sapphyrin and hexaphyrin. The ethoxycarbonyl containing pentaphyrins are the only examples, amongst the expanded polypyrrolic macrocycles, that have an electron withdrawing group directly attached to the macrocyclic ring system. Elimination of a pyrrole and methine carbon unit in the mass spectrometer has been observed as a common feature for the pentaphyrin free bases as well as their metal derivatives.},
	keywords = {COMPLEX, EXPANDED PORPHYRIN, macrocycles, SAPPHYRINS},
	isbn = {0385-5414},
	url = {<Go to ISI>://A1995TF56200017},
	author = {Dansodanquah, R. E. and Xie, L. Y. and Dolphin, D.}
}
