@article {1428,
	title = {Blood compatibility of novel water soluble hyperbranched polyglycerol-based multivalent cationic polymers and their interaction with DNA},
	journal = {Biomaterials},
	volume = {27},
	number = {31},
	year = {2006},
	note = {ISI Document Delivery No.: 085NOTimes Cited: 48Cited Reference Count: 41Kainthan, Rajesh Kumar Gnanamani, Muthiah Ganguli, Munia Ghosh, Tanay Brooks, Donald E. Maiti, Souvik Kizhakkedathu, Jayachandran N.},
	month = {Nov},
	pages = {5377-5390},
	type = {Article},
	abstract = {A novel class of hyperbranched polymers based on polyglycerol (PG) and poly(ethylene glycol) (PEG) are synthesized by multibranching anionic ring opening polymerization. Multivalent cationic sites are added to these polymers by a post-amination and quarternization reactions. Blood compatibility studies using these polymers at different concentrations showed insignificant effects on complement activation, platelet activation, coagulation, erythrocyte aggregation and hemolysis compared to branched cationic polyethyleneimine (PEI). The degree of quarternization does not have large influence on the blood compatibility of the new polymers. Cytotoxicity of these polymers is significantly lower than that of PEI and is a function of quarternized nitrogen present in the polymer. Also, these polymers bind DNA in the nanomolar range and are able to condense DNA to highly compact, stable, water soluble nanoparticles in the range of 60-80 nm. Gel electrophoresis studies showed that they form electroneutral complexes with DNA around N/P ratio 1 irrespective of the percentage of quarternization under the conditions studied. (c) 2006 Elsevier Ltd. All rights reserved.},
	keywords = {AFM, blood-compatibility, cationic polymers, COAGULATION, COMPLEXES, delivery, DNA, drug, GENE DELIVERY, hyperbranched polymers, IN-VITRO, MOLECULAR-WEIGHT, NANOPARTICLES, OPPOSITELY CHARGED SURFACTANT, PLATELETS, RANDOM COPOLYMER, therapy},
	isbn = {0142-9612},
	url = {<Go to ISI>://000240611000005},
	author = {Kainthan, R. K. and Gnanamani, M. and Ganguli, M. and Ghosh, T. and Brooks, D. E. and Maiti, S. and Kizhakkedathu, J. N.}
}
@article {1518,
	title = {Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast},
	journal = {Cell},
	volume = {126},
	number = {3},
	year = {2006},
	note = {ISI Document Delivery No.: 075KITimes Cited: 111Cited Reference Count: 68Parsons, Ainslie B. Lopez, Andres Givoni, Inmar E. Williams, David E. Gray, Christopher A. Porter, Justin Chua, Gordon Sopko, Richelle Brost, Renee L. Ho, Cheuk-Hei Wang, Jiyi Ketela, Troy Brenner, Charles Brill, Julie A. Fernandez, G. Esteban Lorenz, Todd C. Payne, Grego S. Ishihara, Satoru Ohya, Yoshikazu Andrews, Brenda Hughes, Timothy R. Frey, Brendan J. Graham, Todd R. Andersen, Raymond J. Boone, Charles},
	month = {Aug},
	pages = {611-625},
	type = {Article},
	abstract = {Discovering target and off-target effects of specific compounds is critical to drug discovery and development. We generated a compendium of "chemical-genetic interaction" profiles by testing the collection of viable yeast haploid deletion mutants for hypersensitivity to 82 compounds and natural product extracts. To cluster compounds with a similar mode-of-action and to reveal insights into the cellular pathways and proteins affected, we applied both a hierarchical clustering and a factorgram method, which allows a gene or compound to be associated with more than one group. In particular, tamoxifen, a breast cancer therapeutic, was found to disrupt calcium homeostasis and phosphatidylserine (PS) was recognized as a target for papuamide B, a cytotoxic lipopeptide with anti-HIV activity. Further, the profile of crude extracts resembled that of its constituent purified natural product, enabling detailed classification of extract activity prior to purification. This compendium should serve as a valuable key for interpreting cellular effects of novel compounds with similar activities.},
	keywords = {1, 3-BETA-D-GLUCAN SYNTHASE, BREAST-CANCER CELLS, DELETION MUTANTS, drug, EXPRESSION, GENOME-WIDE ANALYSIS, HAPLOINSUFFICIENCY, INDUCED, SACCHAROMYCES-CEREVISIAE, THEONELLA-SWINHOEI, TRANSCRIPTION FACTOR},
	isbn = {0092-8674},
	url = {<Go to ISI>://000239883400019},
	author = {Parsons, A. B. and Lopez, A. and Givoni, I. E. and Williams, D. E. and Gray, C. A. and Porter, J. and Chua, G. and Sopko, R. and Brost, R. L. and Ho, C. H. and Wang, J. Y. and Ketela, T. and Brenner, C. and Brill, J. A. and Fernandez, G. E. and Lorenz, T. C. and Payne, G. S. and Ishihara, S. and Ohya, Y. and Andrews, B. and Hughes, T. R. and Frey, B. J. and Graham, T. R. and Andersen, R. J. and Boone, C.}
}
