@article {3616,
	title = {Development and application of a nonaqueous capillary electrophoresis system for the analysis of porphyrins and their oligomers (PHOTOFRIN)},
	journal = {Analytical Biochemistry},
	volume = {241},
	number = {2},
	year = {1996},
	note = {ISI Document Delivery No.: VV144Times Cited: 34Cited Reference Count: 23},
	month = {Oct},
	pages = {143-150},
	type = {Article},
	abstract = {PHOTOFRIN is a complex porphyrin mixture used in the photodynamic therapy of cancer, A nonaqueous buffer with a polyether additive is used in the development of a capillary electrophoresis method for the analysis of this type of compound. This method achieves partial separation of 60 peaks for PHOTOFRIN in 30 min. A methanol-based buffer is used to improve the efficiency of the separation by decreasing the aggregation of porphyrin, and the resolution is improved by using the electroosmotic flow (EOF) to counterbalance the electrophoretic migration of the analytes. This counter-balancing EOF holds the analytes in the electric field longer, thereby improving the resolution, Brij 35 is used as a complexation reagent to adjust the selectivity and improve the efficiency of the separation, The effects that Brij 35 concentration has on the separation of both monomeric and oligomeric porphyrins are discussed. The polarity of the solvent is adjusted through the addition of water and its effect is rationalized. A qualitative fingerprinting method for characterizing PHOTOFRIN is developed, and different batches and stressed samples are studied. (C) 1996 Academic Press, Inc.},
	keywords = {ANIONS, FLUORESCENCE DETECTION, HEMATOPORPHYRIN, PHOTODYNAMIC THERAPY, PHOTOSENSITIZERS, POLYHEMATOPORPHYRIN, SEPARATION},
	isbn = {0003-2697},
	url = {<Go to ISI>://A1996VV14400001},
	author = {Bowser, M. T. and Sternberg, E. D. and Chen, D. D. Y.}
}
@article {3017,
	title = {1993 SYNTEX-AWARD LECTURE - PHOTOMEDICINE AND PHOTODYNAMIC THERAPY},
	journal = {Canadian Journal of Chemistry-Revue Canadienne De Chimie},
	volume = {72},
	number = {4},
	year = {1994},
	note = {ISI Document Delivery No.: NN830Times Cited: 84Cited Reference Count: 47},
	month = {Apr},
	pages = {1005-1013},
	type = {Article},
	abstract = {Photodynamic therapy (PDT) involves the treatment of diseased tissue and cells using a photosensitizer and visible light. Such photomedical treatments have been known since the time of the ancient Egyptians but it was only just this year that this therapeutic modality was made available to modern medicine with the approval, in Canada, of Photofrin(R) for the treatment of bladder cancer. This paper reviews PDT with an emphasis on drug development, particulary for the second generation drugs, especially BPDMA (benzoporphyrin derivative-mono acid), which is now in human clinical trials.},
	keywords = {BENZOPORPHYRIN DERIVATIVES, CELLS, HEMATOPORPHYRIN, INACTIVATION, MICE, PHOTOSENSITIZATION, PLASMA-LIPOPROTEINS, porphyrins, PROTEIN DAMAGE, PROTOPORPHYRIN},
	isbn = {0008-4042},
	url = {<Go to ISI>://A1994NN83000001},
	author = {Dolphin, D.}
}
@article {7102,
	title = {PHOTOSENSITIZING POTENCY OF STRUCTURAL ANALOGS OF BENZOPORPHYRIN DERIVATIVE (BPD) IN A MOUSE-TUMOR MODEL},
	journal = {British Journal of Cancer},
	volume = {63},
	number = {1},
	year = {1991},
	note = {ISI Document Delivery No.: ER853Times Cited: 85Cited Reference Count: 19},
	month = {Jan},
	pages = {87-93},
	type = {Article},
	abstract = {The in vivo characteristics of four analogues of benzoporphyrin derivative (BPD) have been investigated. Biodistribution data obtained in DBA/2J mice with BPD-MA (monoacid ring A analogue) which had been tritiated or internally labelled with C-14 showed that both labelled materials acted in an essentially identical manner during the period of study. Biodistribution and clearance studies showed that relative distribution in a variety of mouse tissues was similar for all BPD analogues. M1 tumour cells (rhabdomyosarcoma in DBA/2J mice) taken from tumours excised from animals treated 3 h earlier with BPD, and tested in vitro for photosensitivity provided evidence that significant levels of photosensitiser detected in tumour was both active and associated with tumour cells. The monoacid forms of BPD were found to be much more photodynamically active in this test that were the diacid analogues. The ability of the analogues to ablate tumours in mice by photodynamic therapy was also tested. Again, BPD-MA and BPD-MB proved to be measurably better than the diacid analogues. These findings are discussed in reference to structural and physical differences between the analogues.},
	keywords = {HEMATOPORPHYRIN, PHOTOFRIN-II, PHTHALOCYANINES, PLASMA-LIPOPROTEINS, porphyrins, TOXICITY},
	isbn = {0007-0920},
	url = {<Go to ISI>://A1991ER85300018},
	author = {Richter, A. M. and Waterfield, E. and Jain, A. K. and Allison, B. and Sternberg, E. D. and Dolphin, D. and Levy, J. G.}
}
