@article {1505,
	title = {Identification of sokotrasterol sulfate as a novel proangiogenic steroid},
	journal = {Circulation Research},
	volume = {99},
	number = {3},
	year = {2006},
	note = {ISI Document Delivery No.: 070DTTimes Cited: 3Cited Reference Count: 39Murphy, Siun Larrivee, Bruno Pollet, Ingrid Craig, Kyle S. Williams, David E. Huang, Xin-Hui Abbott, Megan Wong, Fred Curtis, Cameron Conrads, Thomas P. Veenstra, Timothy Puri, Mira Hsiang, York Roberge, Michel Andersen, Raymond J. Karsan, Aly},
	month = {Aug},
	pages = {257-265},
	type = {Article},
	abstract = {The potential to promote neovascularization in ischemic tissues using exogenous agents has become an exciting area of therapeutics. In an attempt to identify novel small molecules with angiogenesis promoting activity, we screened a library of natural products and identified a sulfated steroid, sokotrasterol sulfate, that induces angiogenesis in vitro and in vivo. We show that sokotrasterol sulfate promotes endothelial sprouting in vitro, new blood vessel formation on the chick chorioallantoic membrane, and accelerates angiogenesis and reperfusion in a mouse hindlimb ischemia model. We demonstrate that sulfation of the steroid is critical for promoting angiogenesis, as the desulfated steroid exhibited no endothelial sprouting activity. We thus developed a chemically synthesized sokotrasterol sulfate analog, 2 beta,3 alpha,6 alpha-cholestanetrisulfate, that demonstrated equivalent activity in the hindlimb ischemia model and resulted in the generation of stable vessels that persisted following cessation of therapy. The function of sokotrasterol sulfate was dependent on cyclooxygenase-2 activity and vascular endothelial growth factor induction, as inhibition of either cyclooxygenase-2 or vascular endothelial growth factor blocked angiogenesis. Surface expression of alpha(v)beta(3) integrin was also necessary for function, as neutralization of alpha(v)beta(3) integrin, but not beta(1) integrin, binding abrogated endothelial sprouting and antiapoptotic activity in response to sokotrasterol sulfate. Our findings indicate that sokotrasterol sulfate and its analogs can promote angiogenesis in vitro and in vivo and could potentially be used for promoting neovascularization to relieve the sequelae of vasoocclusive diseases.},
	keywords = {ACTIVATION, ANGIOGENESIS, apoptosis, ARTERIOGENESIS, ENDOTHELIAL-CELLS, endothelium, IN-VITRO, INHIBITION, INTEGRIN ALPHA(V)BETA(3), ischemia, MARINE NATURAL-PRODUCTS, NF-KAPPA-B},
	isbn = {0009-7330},
	url = {<Go to ISI>://000239501200009},
	author = {Murphy, S. and Larrivee, B. and Pollet, I. and Craig, K. S. and Williams, D. E. and Huang, X. H. and Abbott, M. and Wong, F. and Curtis, C. and Conrads, T. P. and Veenstra, T. and Puri, M. and Hsiang, Y. and Roberge, M. and Andersen, R. J. and Karsan, A.}
}
@article {796,
	title = {Research achievement award-D. John Faulkner},
	journal = {Journal of Natural Products},
	volume = {67},
	number = {8},
	year = {2004},
	note = {ISI Document Delivery No.: 850GWTimes Cited: 2Cited Reference Count: 130},
	month = {Aug},
	pages = {1239-1251},
	type = {Review},
	abstract = {David John Faulkner, one of the pioneers of marine natural products chemistry and the 2003 recipient of the ASP Research Achievement Award, passed away on November 23, 2002. John was very pleased to learn that he{\textquoteright}d been named as the award recipient and was intending to present the ASP Research Achievement Award Address at the annual meeting in July 2003, Chapel Hill, North Carolina. John{\textquoteright}s untimely death left an unprecedented event in the history of the ASP-a posthumous Research Achievement Award to a deserving individual and an untimely loss for us all. We are bereft of a colleague, a friend, and a mentor, and the opportunity to hear John{\textquoteright}s words on the occasion of his own award. In tribute to John, we have assembled a retrospective of John{\textquoteright}s work that is not meant to be a comprehensive review (this would take considerably more space) but a selection of highlights and personal vignettes from some of those that trained in marine natural products under his mentorship. This paper is a written account of the symposium presented by the authors at the ASP Annual Meeting in Chapel Hill, North Carolina, on July 16, 2003.},
	keywords = {ANTIFUNGAL, APLYSINA-FISTULARIS VERONGIA, CYCLIC-PEPTIDES, JUVENILE-HORMONE, MARINE NATURAL-PRODUCTS, NUDIBRANCH HEXABRANCHUS-SANGUINEUS, POLYPROPIONATE METABOLITES, PULMONATE, SIPHONARIA-DENTICULATA, SPONGE DYSIDEA-HERBACEA, THEONELLA-SWINHOEI, TRISUBSTITUTED OLEFINIC BONDS},
	isbn = {0163-3864},
	url = {<Go to ISI>://000223600200007},
	author = {Andersen, R. J. and Ireland, C. M. and Molinski, T. F. and Bewley, C. A.}
}
@article {4540,
	title = {Papuamides A-D, HIV-inhibitory and cytotoxic depsipeptides from the sponges Theonella mirabilis and Theonella swinhoei collected in Papua New Guinea},
	journal = {Journal of the American Chemical Society},
	volume = {121},
	number = {25},
	year = {1999},
	note = {ISI Document Delivery No.: 212KXTimes Cited: 83Cited Reference Count: 32},
	month = {Jun},
	pages = {5899-5909},
	type = {Article},
	abstract = {The novel cyclic depsipeptides papuamides A (1), B (2), C (3), and D (4) have been isolated from Papua New Guinea collections of the sponges Theonella mirabilis and Theonella swinhoei. Their structures were determined by a combination of spectroscopic analysis and chemical degradation and derivatization studies. In addition to glycine, alanine, and threonine, these peptides contain a number of unusual amino acids including 3,4-dimethylglutamine, beta-methoxytyrosine, 3-methoxyalanine, and 2,3-diaminobutanoic acid or 2-amino-2-butenoic acid residues. Papuamides A-D (1-4) are also the first marine-derived peptides reported to contain 3-hydroxyleucine and homoproline residues. These peptides also contain a previously undescribed 2,3-dihydroxy-2,6,8-trimethyldeca-(4Z,6E)-dienoic acid moiety N-linked to a terminal glycine residue. Papuamides A (1) and B (2) inhibited the infection of human T-lymphoblastoid cells by HIV-1(RF) in vitro with an EC50 of approximately 4 ng/mL. Compound 1 was also cytotoxic against a panel of human cancer cell lines with a mean IC50 of 75 ng/mL.},
	keywords = {ACIDS, ANTIFUNGAL CYCLIC-PEPTIDES, CALLIPELTA, CYCLOTHEONAMIDES, ENANTIOMERICALLY PURE, GLYCOPEPTIDE, inhibitors, MARINE NATURAL-PRODUCTS, MOZAMBIQUE, POTENT THROMBIN INHIBITORS, SERINE-PROTEASE, SP},
	isbn = {0002-7863},
	url = {<Go to ISI>://000081216800007},
	author = {Ford, P. W. and Gustafson, K. R. and McKee, T. C. and Shigematsu, N. and Maurizi, L. K. and Pannell, L. K. and Williams, D. E. and De Silva, E. D. and Lassota, P. and Allen, T. M. and Van Soest, R. and Andersen, R. J. and Boyd, M. R.}
}
@article {4034,
	title = {Investigations of terpenoid biosynthesis by the dorid nudibranch Cadlina luteomarginata},
	journal = {Journal of Organic Chemistry},
	volume = {62},
	number = {21},
	year = {1997},
	note = {ISI Document Delivery No.: YC657Times Cited: 16Cited Reference Count: 21},
	month = {Oct},
	pages = {7239-7246},
	type = {Article},
	abstract = {Stable isotope incorporation studies with [1,2-C-13(2)]acetate, [1,2-C-13(2),O-18(1)]acetate, [1,2-C-13],mevalonolactone, and [2-C-13]mevalonolactone have been used to investigate the biosynthesis of the terpenoids albicanyl acetate (1), cadlinaldehyde (2), and luteone (3) by the dorid nudibranch Cadlina luteomarginata. The results have shown that all three terpenoids are synthesized de novo by C, luteomarginata and the incorporation patterns are consistent with the biogenetic proposal that the new cadlinalane and luteane carbon skeletons are formed by degradation of a sesterterpenoid precursor. This represents the first demonstration of sesterterpenoid biosynthesis by a marine mollusc. Quantitative analysis has shown that only a small turnover of metabolites takes place during the feeding experiments but that the newly formed molecules have extremely high levels of incorporation of labeled precursors.},
	keywords = {CARBON SKELETON, CHEMICAL DEFENSE, MARINE NATURAL-PRODUCTS, SPONGE APLYSILLA-GLACIALIS},
	isbn = {0022-3263},
	url = {<Go to ISI>://A1997YC65700039},
	author = {Kubanek, J. and Graziani, E. I. and Andersen, R. J.}
}
@article {3682,
	title = {Stable isotope incorporation evidence for a polyacetate origin of the acyl residues in triophamine, a diacylguanidine metabolite obtained from the dorid nudibranch Triopha catalinae},
	journal = {Chemical Communications},
	number = {20},
	year = {1996},
	note = {ISI Document Delivery No.: VP467Times Cited: 11Cited Reference Count: 16},
	month = {Oct},
	pages = {2377-2378},
	type = {Article},
	abstract = {Biosynthetic feeding experiments with sodium [1,2-(13)-C-2]-acetate have shown that the acyl residues of triophamine 1 are formed de novo in Triopha catalinae from five intact acetate units.},
	keywords = {biosynthesis, DEFENSE, MARINE NATURAL-PRODUCTS, MOLLUSKS},
	isbn = {1359-7345},
	url = {<Go to ISI>://A1996VP46700036},
	author = {Graziani, E. I. and Andersen, R. J.}
}
@article {3684,
	title = {Stable isotope incorporation evidence for the de novo biosynthesis of terpenoic acid glycerides by dorid nudibranchs},
	journal = {Tetrahedron},
	volume = {52},
	number = {20},
	year = {1996},
	note = {ISI Document Delivery No.: UK089Times Cited: 18Cited Reference Count: 19},
	month = {May},
	pages = {6869-6878},
	type = {Article},
	abstract = {Feeding experiments with [1,2-C-13(2)]acetate have been used to demonstrate that the dorid nudibranchs Archidoris odhneri and A. montereyensis are capable of de novo biosynthesis of the terpenoic acid glycerides 1 and 4. Feeding experiments using [2-C-13] mevalonolactone as a precursor have shown that Sclerodoris tanya is capable of de novo biosynthesis of the terpenoid fragment of tanyolide B (7). Copyright (C) 1996 Elsevier Science Ltd},
	keywords = {ICHTHYOTOXIC DIACYLGLYCEROL, MARINE NATURAL-PRODUCTS},
	isbn = {0040-4020},
	url = {<Go to ISI>://A1996UK08900003},
	author = {Graziani, E. I. and Andersen, R. J. and Krug, P. J. and Faulkner, D. J.}
}
@article {7080,
	title = {RUBROLIDES-A-H, METABOLITES OF THE COLONIAL TUNICATE RITTERELLA-RUBRA},
	journal = {Journal of Organic Chemistry},
	volume = {56},
	number = {22},
	year = {1991},
	note = {ISI Document Delivery No.: GM576Times Cited: 53Cited Reference Count: 25},
	month = {Oct},
	pages = {6275-6280},
	type = {Article},
	abstract = {Rubrolides A (1) to H (8), a new family of biologically active tunicate metabolites, have been isolated from Ritterella rubra. The structures of the rubrolides were solved by a combination of spectroscopic analysis and chemical interconversions. Rubrolides B (2) and H (8) represent some of the first chlorinated metabolites known from tunicates. The rubrolides are potent in vitro antibiotics and they show moderate but selective inhibition of protein phosphatases 1 and 2A.},
	keywords = {C-13 ASSIGNMENTS, CARIBBEAN TUNICATE, ECTEINASCIDIA-TURBINATA, H-1, MARINE NATURAL-PRODUCTS, NMR, SIGILLINOIDES},
	isbn = {0022-3263},
	url = {<Go to ISI>://A1991GM57600012},
	author = {Miao, S. C. and Andersen, R. J.}
}
