@article {1112,
	title = {Chromatographic separation and identification of products from the reaction of dimethylarsinic acid with hydrogen sulfide},
	journal = {Chemical Research in Toxicology},
	volume = {18},
	number = {12},
	year = {2005},
	note = {ISI Document Delivery No.: 004XYTimes Cited: 24Cited Reference Count: 44},
	month = {Dec},
	pages = {1821-1829},
	type = {Article},
	abstract = {The reaction of dimethylarsinic acid (DMA(V)) with hydrogen sulfide (H2S) is of biological significance and may be implicated in the overall toxicity and carcinogenicity of arsenic. The course of the reaction in aqueous phase was monitored, and an initial product, dimethylthioarsinic acid, was observed by using LC-ICP-MS and LC-ESI-MS. Dimethylarsinous acid was observed as a minor product. A second slower-forming product was identified, and the electrospray mass chromatograms for this species produced ions at m/z 275, 171, and 137 in positive mode. To aid in the identification of this slower-forming product, crystalline standards of sodium dimethyldithioarsinate and dimethylarsino dimethyldithioarsinate were prepared and re-characterized by using improved spectroscopic and structural analysis techniques. An aqueous solution of sodium dimethyldithioarsinate produced a single major chromatographic peak that matched the retention time (7.6 min) of the slower-forming product and contained similar molecular ions at m/z 275, 171, and 137 via LC-ESI-MS. The dimethylarsino dimethyldithioarsinate standard produced four aqueous phase species one of which coeluted with the slower forming product. This coeluting peak also produced the identical ESI-MS ions as the slower-forming product of DMA(V) + H2S. ESI-MS/MS experiments conducted on sodium dimethyldithioarsinate in deuterated water produced molecular ions at m/z 276, 173, and 137. Subsequent collisionally activated dissociation (CAD) experiments on m/z 276 did not produce a product ion at m/z 173. These data indicate that two different species are present in solution, while NMR data indicate that only dimethyldithioarsinic acid exists in aqueous solutions. This discrepancy was investigated by conducting NMR studies on the acidic solution of sodium dimethyldithioarsinate after taking this solution to dryness. The resolubilized solution produced a proton NMR signal characteristic of dimethylarsino dimethyldithioarsinate. Therefore, it was concluded that the ESI-MS ion at m/z 275 associated with the slowly forming second reaction product and the sodium dimethyldithioarsinate compound is a product of the ESI desolvation process.},
	keywords = {CRYSTAL-STRUCTURE, DIMETHYLDITHIOARSINATE, GLUTATHIONE, METABOLITE, ORGANIC ARSENIC COMPOUNDS, RATS, REARRANGEMENT, TOXICITY, TRIMETHYLARSINE OXIDE, urine},
	isbn = {0893-228X},
	url = {<Go to ISI>://000234787200005},
	author = {Fricke, M. W. and Zeller, M. and Sun, H. and Lai, V. W. M. and Cullen, W. R. and Shoemaker, J. A. and Witkowski, M. R. and Creed, J. T.}
}
@article {3289,
	title = {ARSENIC BIOMETHYLATION BY THE MICROORGANISM APIOTRICHUM HUMICOLA IN THE PRESENCE OF L-METHIONINE-METHYL-D(3)},
	journal = {Applied Organometallic Chemistry},
	volume = {9},
	number = {7},
	year = {1995},
	note = {ISI Document Delivery No.: TG189Times Cited: 15Cited Reference Count: 273rd International Conference on Environmental and Biological Aspects of Main Group Organometals (ICEBAMO 94)SEP, 1994BORDEAUX, FRANCESoc Francaise Chim, Royal Soc Chem, CNRS, EC Measurement \& Testing Program, French Minist Environm, French Minist Res \& Technol, Univ Bordeaux I, Univ Bordeaux II, IFREMER, INRA, Conseil Reg Aquitaine, Lyonnaise Eaux Dumez Water Co., Thermo Jarell Ash, John Wiley \& Sons, Freund Publ, Elsevier Sci Publ},
	month = {Nov},
	pages = {507-515},
	type = {Proceedings Paper},
	abstract = {The microorganism Apiotrichum humicola (previously known as Candida humicola) grown in the presence of either arsenate, arsenite, methyl-arsonic acid or dimethylarsinic acid, produces arsenic-containing metabolites in the growth medium. When L-methionine-methyl-d(3) is added to the cultures, the CD3 label is incorporated intact into the metabolites to a considerable extent to form deuterated dimethylarsenic and trimethylarsenic species, indicating that S-adenosylmethionine, or some related sulphonium compound, is involved in the biological methylation. Conclusive evidence of CD3 incorporation in the arsenicals found in the growth medium was provided by using a specially developed hydride generation-gas chromatography-mass spectrometry system (HG-GC-MS).},
	keywords = {ARSENATE, ARSENITE, CHROMATOGRAPHY MASS SPECTROMETRY, DIMETHYLARSINIC ACID, EXTRACELLULAR, GAS, HYDRIDE GENERATION, HYDRIDE GENERATION GAS, L-METHIONINE-METHYL-D(3), methylarsonic acid, METHYLATION, MICROORGANISM, REDUCTION, S-ADENOSYLMETHIONINE, THIOLS, TRIMETHYLARSINE OXIDE},
	isbn = {0268-2605},
	url = {<Go to ISI>://A1995TG18900002},
	author = {Cullen, W. R. and Li, H. and Pergantis, S. A. and Eigendorf, G. K. and Mosi, A. A.}
}
@article {3002,
	title = {IDENTIFICATION OF EXTRACELLULAR ARSENICAL METABOLITES IN THE GROWTH-MEDIUM OF THE MICROORGANISMS APIOTRICHUM-HUMICOLA AND SCOPULARIOPSIS-BREVICAULIS},
	journal = {Applied Organometallic Chemistry},
	volume = {8},
	number = {4},
	year = {1994},
	note = {ISI Document Delivery No.: PD643Times Cited: 34Cited Reference Count: 28},
	month = {Jul},
	pages = {303-311},
	type = {Article},
	abstract = {The separation and identification of some of the arsenic species produced in cells present in the growth medium when the microorganisms Apiotrichum humicola (previously known as Candida humicola) and Scopulariopsis brevicaulis were grown in the presence of arsenicals were achieved by using hydride generation-gas chromatography-atomic absorption spectrometry methodology (HG GC AA). Arsenite, monomethylarsonate, dimethylarsinate and trimethylarsine oxide were detected following incubation with arsenate. With arsenite as a substrate, the metabolites were monomethylarsonate, dimethylarsinate and trimethylarsine oxide; monomethylarsonate afforded dimethylarsinate and trimethylarsine oxide, and dimethylarsinate afforded trimethylarsine oxide. Trimethylarsine was not detected when the arsenic concentration was 1 ppm.},
	keywords = {APIOTRICHUM-HUMICOLA, arsenic, CANDIDA-HUMICOLA, DIMETHYULARSINATE, ENDOCELLULAR, EXTRACELLULAR, GROWTH MEDIUM, HYDRIDE GENERATION GAS CHROMATOGRAPHY ATOMIC ABSORPTION SPECTROMETRY, METHYLARSONATE, METHYLATION, mobility, SCOPULARIOPSIS-BREVICAULIS, TRIMETHYLARSINE, TRIMETHYLARSINE OXIDE},
	isbn = {0268-2605},
	url = {<Go to ISI>://A1994PD64300003},
	author = {Cullen, W. R. and Li, H. and Hewitt, G. and Reimer, K. J. and Zalunardo, N.}
}
@article {3091,
	title = {SPECIATION OF ARSENIC COMPOUNDS IN SOME MARINE ORGANISMS},
	journal = {Environmental Science \& Technology},
	volume = {28},
	number = {9},
	year = {1994},
	note = {ISI Document Delivery No.: PE258Times Cited: 43Cited Reference Count: 49},
	month = {Sep},
	pages = {1598-1604},
	type = {Article},
	abstract = {Speciation of arsenic compounds in some marine algae, bivalves, and crustaceans was studied by using two techniques: (i) high-performance liquid chromatography with inductively coupled plasma mass spectrometry detection and (ii) hydride generation atomic absorption spectrometry following microwave-assisted digestion. Arsenosugars were identified as the major arsenic compounds present in marine algae, whereas arsenobetaine was the dominant arsenic species present in crab and shrimp. In contrast to most previous reports, which claimed arsenobetaine as the only major arsenic species present in marine bivalves, this study revealed the presence of arsenosugars in addition to arsenobetaine in the bivalves. The speciation of arsenic in sample extracts and {\textquoteright}{\textquoteright}defrost liquid{\textquoteright}{\textquoteright} from previously frozen marine animal samples revealed that up to 48\% of the total arsenic in the sample can be released in the defrost liquid. Arsenic species found in the defrost liquid were identical with those in the sample extracts. Changes in arsenic speciation were observed in the sample extracts that were stored for a long term. Arsenobetaine in sample extracts that were stored at 4 degrees C for 9 months was decomposed to trimethylarsine oxide and two other unidentified arsenic species.},
	keywords = {ARSENIC COMPOUNDS, arsenobetaine, ATOMIC-ABSORPTION SPECTROMETRY, BOMBARDMENT MASS-SPECTROMETRY, ECKLONIA-RADIATA, HOMARUS-AMERICANUS, IDENTIFICATION, KELP, ORGANOARSENIC COMPOUNDS, TRACE-ELEMENTS, TRIMETHYLARSINE OXIDE},
	isbn = {0013-936X},
	url = {<Go to ISI>://A1994PE25800015},
	author = {Le, S. X. C. and Cullen, W. R. and Reimer, K. J.}
}
@article {2767,
	title = {DESORPTION CHEMICAL IONIZATION MASS-SPECTROMETRY OF ARSENIC COMPOUNDS PRESENT IN THE MARINE AND TERRESTRIAL ENVIRONMENT},
	journal = {Rapid Communications in Mass Spectrometry},
	volume = {7},
	number = {1},
	year = {1993},
	note = {ISI Document Delivery No.: KJ908Times Cited: 16Cited Reference Count: 18},
	month = {Jan},
	pages = {33-36},
	type = {Article},
	abstract = {The advantages of desorption chemical ionization mass spectrometry (DCI-MS) for characterizing arsenic compounds that exist in the environment include the presence in the spectra of recognizable molecular ions as well as structurally characteristic fragment ions. Satisfactory spectra can be obtained with 100 ng arsenic on the DCI filament, making the technique eminently suitable for the investigation of environmental samples.},
	keywords = {arsenobetaine, FAST ATOM BOMBARDMENT, IDENTIFICATION, SHRIMPS, TRIMETHYLARSINE OXIDE},
	isbn = {0951-4198},
	url = {<Go to ISI>://A1993KJ90800007},
	author = {Cullen, W. R. and Eigendorf, G. K. and Pergantis, S. A.}
}
