@inbook {2453,
	title = {New Chemistry, Including Pulp Bleaching Processes, of the Golden-Aged, Water-Soluble Compound, Tris(hydroxymethyl)phosphine},
	booktitle = {Catalysis of Organic Reactions},
	series = {Chemical Industries},
	volume = {123},
	year = {2009},
	note = {ISI Document Delivery No.: BLT07Times Cited: 0Cited Reference Count: 85James, Brian R.Proceedings Paper22nd Conference on Catalysis of Organic ReactionsMAR 30-APR 03, 2008Richmond, VAOrgan React Catalysis Soc, Avantium, BASF Catalysis LLC, Eli Lilly, Evonik Degussa Corp, WR Grace, Davison Catalysts, Parr Instrument, Air Prod, Amgen, Eastman, Umicore, Bristol Myers Squibb, DuPont, Headwaters, HEI, Lummus Technol, OMG, Seton Hall Univ, Sud Chem6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA},
	pages = {1-14},
	publisher = {Crc Press-Taylor \& Francis Group},
	organization = {Crc Press-Taylor \& Francis Group},
	address = {Boca Raton},
	abstract = {Collaborative studies with the Pulp and Paper Institute of Canada (Paprican) have led serendipitously to development of a pulp bleaching process using tris(hydroxymethyl)phosphine, P(CH2OH)(3) (abbreviated THP), and this on-going work is reviewed. Work on hydrogenation of aromatic residues in lignin, using transition metal catalysts under homogeneous, aqueous-phase conditions, led to the discovery that commercially available THP, in the absence of any metal, bleached selected pulps. Use of THP or a related diphosphine 2 is competitive with the currently used bleaching agents, hydrosulfite (S2O42-) and alkaline peroxide. (Hydroxymethyl)phosphines react as strong nucleophiles and/or reductants toward unsaturated chromophore moieties of lignin, decreasing the degree of conjugation, and hence leading to bleaching. The resulting phosphorus-containing moieties in the lignin also give a more permanent brightening of the pulp. The organo-phosphorus chemistry realized is relevant to other processes catalyzed homogeneously by transition metal-phosphine systems. In situ metal-THP species can catalyze hydrogenation of C=C and/or C=O bonds in lignin chromophores, and investigations on such systems have unearthed new THP-promoted transition metal chemistry.},
	keywords = {BIPHASIC CONDITIONS, BRIGHTNESS STABILIZING AGENTS, CATALYTIC-HYDROGENATION, CLUSTER CATALYSIS, HOMOGENEOUS CATALYST, LIGNIN MODEL COMPOUNDS, mechanical, PHOSPHORUS-COMPOUNDS, pulps, ruthenium complexes, TERTIARY PHOSPHINES},
	isbn = {978-1-4200-7076-7},
	url = {<Go to ISI>://000270967300001},
	author = {James, Brian R.},
	editor = {Prunier, M. L.}
}
@article {716,
	title = {Dichloro(diphosphine)(2-pyridyl-ketone)ruthenium(II) complexes},
	journal = {Canadian Journal of Chemistry-Revue Canadienne De Chimie},
	volume = {81},
	number = {11},
	year = {2003},
	note = {ISI Document Delivery No.: 746YXTimes Cited: 9Cited Reference Count: 31},
	month = {Nov},
	pages = {1263-1269},
	type = {Article},
	abstract = {Described are the synthesis and characterization of Ru(II) complexes of the type RuCl2L2(N-O), where L-2 is either 1,4-bis(diphenylphosphino)butane (dppb) or (PPh3)(2), and N-O represents chelated 2-benzoylpyridine (2-bzpy) or 2-acetylpyridine (2-acpy); the Ru presursors used were [RuCl2(dppb)](2)(mu-dppb) or RuCl2(PPh3)(3). The crystal structure of cis-RuCl2(dppb)(2-bzpy) is presented, and three other RuCl2L2(N-O) complexes with cis-chlorines are isolated and characterized spectroscopically; of the trans-dichloro species, RuCl2(PPh3)(2)(N-O) complexes are isolated, while the corresponding dppb species are characterized in situ. In all cases, thermodynamically stable cis-complexes are formed from initially formed trans-species.},
	keywords = {2, 2-acetylpyridine, 2-benzoylpyridine, 2{\textquoteright}-BIPYRIDINE, CRYSTAL-STRUCTURE, DONOR, ISOMERIZATION, LIGANDS, phosphines, REDOX POTENTIALS, ruthenium, ruthenium complexes, structures, X-RAY},
	isbn = {0008-4042},
	url = {<Go to ISI>://000186777600018},
	author = {Queiroz, S. L. and Batista, A. A. and de Araujo, M. P. and Bianchini, R. C. and Oliva, G. and Ellena, J. and James, Brian R.}
}
@article {641,
	title = {The synthesis, structural characterization, and in vitro anti-cancer activity of chloro(p-cymene) complexes of ruthenium(II) containing a disulfoxide ligand},
	journal = {Inorganica Chimica Acta},
	volume = {352},
	year = {2003},
	note = {ISI Document Delivery No.: 711FATimes Cited: 39Cited Reference Count: 47},
	month = {Aug},
	pages = {238-246},
	type = {Article},
	abstract = {Two diruthenium(II) complexes [RuCl2(p-cymene)](2)(mu-BESE) (1), [RuCl2(p-cymene)](2)(mu-BESP) (2), and the mononuclear salt [RuCl(p-cymene)(BESE)]PF6 (3), containing the disulfoxides BESE and BESP, were synthesized and characterized by elemental analysis, and NMR and IR spectroscopies, and were shown to contain S-bound sulfoxide groups; the disulfoxides are EtS(O)(CH2)(n) S(O)Et, where n = 2 (BESE) or 3 (BESP). Complexes 1 and 3 were also characterized by X-ray crystallography. Preliminary in vitro tests of I and 3 were conducted using the MTT assay, which measures mitochondrial dehydrogenase activity as an indication of cell viability; these complexes showed in vitro anti-cancer activity against a human mammary cancer cell line (MDA-MB-435s) with IC50 values of 360 and 55 muM, respectively. (C) 2003 Elsevier B.V. All rights reserved.},
	keywords = {anti-cancer activity, arene complexes, CANCER, cell, COMPLEX, COORDINATION, crystal structures, CRYSTAL-STRUCTURE, DIMETHYL-SULFOXIDE LIGAND, DIRUTHENIUM(II), disulfoxide ligands, INHIBITION, p-Cymene complexes, RADIOSENSITIZING ACTIVITY, ruthenium complexes, SOLUTION CHEMISTRY},
	isbn = {0020-1693},
	url = {<Go to ISI>://000184727900029},
	author = {Huxham, L. A. and Cheu, E. L. S. and Patrick, B. O. and James, Brian R.}
}
@article {5102,
	title = {Bis(mercapto) and hydrido(thiolate) complexes of Ru(II)-dppm (dppm = Ph2PCH2PPh2)},
	journal = {Inorganica Chimica Acta},
	volume = {320},
	number = {1-2},
	year = {2001},
	note = {ISI Document Delivery No.: 472CETimes Cited: 6Cited Reference Count: 33},
	month = {Aug},
	pages = {184-189},
	type = {Article},
	abstract = {From a mixture of cis- and trans-Ru(SH)(2)(dppm)(2) (4), formed from reaction of H2S with trans-Ru(H)Cl(dppm)(2) (2), a crystal of cis-4 has been isolated and its structure determined by X-ray analysis. The mercapto protons are located within the centrosymmetric structure, although the S-atoms are partially disordered (S - H similar to 1.06 Angstrom). The thiolate complexes, trans-Ru(H)SR(dppm)(2) (R = Ph, 5a; C6F5, 5b), have been isolated from reaction of trans-2 with 1 equiv. of RSH. trans-Ru(H)SH(dppm)(2) (3) has been isolated from reaction of H2S with a mixture of cis- and trans-Ru(H)(2)(dppm)(2) (1). An improved synthetic route for 1 is presented. (C) 2001 Elsevier Science B.V. All rights reserved.},
	keywords = {CHEMISTRY, COMPLEXES, crystal structures, CRYSTAL-STRUCTURE, DERIVATIVES, DINUCLEAR RHODIUM COMPLEXES, hydrido complexes, HYDROFORMYLATION, MECHANISMS, MERCAPTO, PHOSPHINE COMPLEXES, ruthenium complexes, RUTHENIUM(II), THIOLATO, WATER},
	isbn = {0020-1693},
	url = {<Go to ISI>://000170965000025},
	author = {Khorasani-Motlagh, M. and Safari, N. and Pamplin, C. B. and Patrick, B. O. and James, Brian R.}
}
@article {4280,
	title = {Chelate ring-opening ruthenium complexes: X-ray crystal structure and solution studies of cis,trans-bis(2-dimethyl-aminoethyl)diphenylphosphino(dichloro)ruthenium (II)},
	journal = {Inorganica Chimica Acta},
	volume = {273},
	number = {1-2},
	year = {1998},
	note = {ISI Document Delivery No.: ZP204Times Cited: 13Cited Reference Count: 34XXXIII International Conference on Coordination ChemistryAUG 30-SEP 04, 1998FLORENCE, ITALY},
	month = {May},
	pages = {1-7},
	type = {Proceedings Paper},
	abstract = {{The Ru(II) complex cis,trans-[Ru(Me(2)NCH(2)Ch(2)PPh(2)-P,N)(2)Cl-2] (1) has been characterized in the solid state and in solution. X-ray crystallography showed that complex 1 is monoclinic, space group C-2/c; a = 36.0421},
	keywords = {aminophosphine complexes, chelate ring complexes, crystal structures, DERIVATIVES, IMIDAZOLE, METAL-COMPLEXES, PHOSPHINE-LIGANDS, ruthenium complexes, SERIES},
	isbn = {0020-1693},
	url = {<Go to ISI>://000073728200002},
	author = {Guo, Z. J. and Habtemariam, A. and Sadler, P. J. and James, Brian R.}
}
@article {4297,
	title = {Intramolecular protonation and other mechanisms for substitution reactions of hydrido(thiolato)- and di(thiolato)-ruthenium(II) phosphine complexes},
	journal = {Inorganica Chimica Acta},
	volume = {280},
	number = {1-2},
	year = {1998},
	note = {ISI Document Delivery No.: 124VGTimes Cited: 3Cited Reference Count: 28},
	month = {Oct},
	pages = {75-86},
	type = {Article},
	abstract = {Reactions of cct-RuH(SR) (CO)(2)(PPh3)(2) (1) (cct = cis, cis, traits) with R{\textquoteright}SH provide cct-RuH(SR{\textquoteright}) (CO)(2)(PPh3)(2) (R = alkyl, aryl); based on described kinetic data, the proposed mechanism involves PPh3 loss, coordination of R{\textquoteright}SH, intramolecular protonation of RS- by R{\textquoteright}SH, and RSH elimination. The intramolecular protonation step circumvents a potentially slow RSH reductive elimination step. A similar mechanism is proposed for the thiol exchange reactions of cct-Ru(SR)(2)(CO)(2)(PPh3)(2) (2). A corresponding dissociative mechanism is also proposed for the reaction of 1 with P(p-tolyl)(3), which gives cct-RuH(SR) (CO)(2)(PPh3) (P(p-tolyl)(3)) and cct-RuH(SR) (CO)(2)(P(p-tolyl)(3))(2). Other reactions described include the reactions of 1 with H-2, CO, HCl and PPh3, and the reactions of 2 with P(p-tolyl)(3) and H-2. Exposure to light causes 2 to dimerize in solution. (C) 1998 Elsevier Science S.A. All rights reserved.},
	keywords = {ACTIVE-SITES, EXCHANGE, hydride complexes, IRON-SULFUR PROTEINS, kinetics and mechanism, LIGANDS, MOLECULAR-HYDROGEN, nitrogenase, ruthenium complexes, SYNTHETIC ANALOGS, TETRANUCLEAR CLUSTERS <FE4S4(SR)4>2, thiolate complexes, THIOLATO, TRANSITION-METAL COMPLEXES},
	isbn = {0020-1693},
	url = {<Go to ISI>://000076202900012},
	author = {Jessop, P. G. and James, Brian R.}
}
@article {4340,
	title = {Triply-bridged diruthenium(II) 1,4-bis(diphenylphosphino)butane (dppb) and (R)-2,2 {\textquoteright}-bis(diphenylphosphino)-1,1 {\textquoteright}-binaphthyl (binap) complexes, including structural characterisation of [(dppb)ClRu(mu-D2O)-(mu-Cl)(2)RuCl(dppb)], [(eta(2)-H-2)(dppb)Ru(m},
	journal = {Inorganica Chimica Acta},
	volume = {270},
	number = {1-2},
	year = {1998},
	note = {ISI Document Delivery No.: ZD760Times Cited: 31Cited Reference Count: 57},
	month = {Apr},
	pages = {130-144},
	type = {Article},
	abstract = {{Several triply-bridged diruthenium(II)(1,4-bis(diphenylphosphino)butane) complexes were synthesised and characterised by elemental analysis, UV-Vis, NMR and IR spectroscopies, The solid-state structures of [(dppb)ClRu(mu-D2O)(mu-Cl)(2)RuCl(dppb)] (1), [(eta(2)-H-2) (dppb)Ru(mu-Cl)(3)RuCl(dppb)] (2) and [TMP][(dppb)ClRu(mu-Cl)(3)RuCl(dppb)] (3) were established by X-ray crystallographic analyses (TMP=1,1,3-trimethyl-2,3-dihydroperimidinium; dppb = Ph2P(CH2)(4)PPh2). Crystals of 1.1.5C(6)D(6), 2.1.5C(7)D(8) and 3.2Me(2)CO.2H(2)O are all monoclinic, space groups P2(1)/c, P2(1)/n and C2/c, respectively, with Z=4: a=16.8681(6)},
	keywords = {ASYMMETRIC HYDROGENATION, catalytic activity, crystal structures, CRYSTAL-STRUCTURE, DEHYDROGENATION, DINUCLEAR, diphosphine complexes, GENERAL-SYNTHESIS, LIGANDS, PHOSPHINE COMPLEXES, REACTIVITY, ruthenium complexes, triply-bridged complexes},
	isbn = {0020-1693},
	url = {<Go to ISI>://000072720900018},
	author = {Macfarlane, K. S. and Thorburn, I. S. and Cyr, P. W. and Chau, Deky and Rettig, S. J. and James, Brian R.}
}
@article {3644,
	title = {Benzynechromium tricarbonyl. Further synthetic studies},
	journal = {Inorganica Chimica Acta},
	volume = {251},
	number = {1-2},
	year = {1996},
	note = {ISI Document Delivery No.: VX967Times Cited: 5Cited Reference Count: 21},
	month = {Oct},
	pages = {53-64},
	type = {Article},
	abstract = {{The thermolysis of Ru-3(CO)(11)[Ph(2)PC(6)H(5)Cr(CO)(3)] affords two isomers of the benzyne derivative Ru-3(CO)(7)(C6H4)[PPhC(6)H(5)Cr(CO)(3)](2) ((5) and (6)). The crystal structure of 5, previously determined, shows the phenyl groups are trans to the Ru-3-triangle; in 6 they are probably cis and on the same side of the Ru-3-triangle as the benzyne moiety. Os-3(CO)(11)[Ph(2)PC(6)H(5)Cr(CO)(3)] decomposes on heating to afford a benzyne derivative of a less common class Os-3(CO)(9)(C6H4)[PC6H5Cr(CO)(3)] (7), and an electron deficient molecule Os-3(CO)(8)(PhPC(6)H(4))[Ph(2)PC(6)H(5)Cr(CO)(3)] (8), in which the PhPC(6)H(4) moiety acts as a four-electron donor. The isopropylphosphine derivatives M(3)(CO)(11)[(Pr2PC6H5Cr)-P-i(CO)(3)] (M=Ru, Os), also undergo thermolysis to afford HRu3(CO)(8)[C6H4Cr(CO)(3)](PPr2i) (10), Ru(CO)(3)[(Pr2PC6H5Cr)-P-i(CO)(3)](2) (11), H2Os3(CO)(8)[(PrPC6H4Cr)-P-i(CO)(3)] (12) and H2Os3(CO)(8)[(PrPC6H4Cr)-P-i(CO)(3)][(Pr2PC6H5Cr)-P-i(CO)(3)] (13). Complex 10 is probably a benzynechromium tricarbonyl derivative with a Cr-Ru bond. The phosphines are trans in complex 11, a derivative of Ru(CO)(5). The structures of complexes 12 and 13 are closely related and the orthometalated [PC6H4Cr(CO)(3)] moiety is acting as a four-electron donor to the cluster. Crystal data: for 8 (C41H24CrO11Os3P2 . CH2Cl2): monoclinic},
	keywords = {(BENZYNE)CHROMIUM TRICARBONYL, BENZYNE, carbonyl complexes, CHROMIUM COMPLEXES, cluster complexes, CLUSTERS, COMPLEXES, crystal structures, CRYSTAL-STRUCTURES, MOLECULAR-STRUCTURES, OSMIUM, osmium complexes, ruthenium complexes},
	isbn = {0020-1693},
	url = {<Go to ISI>://A1996VX96700009},
	author = {Cullen, W. R. and Rettig, S. J. and Zhang, H. L.}
}
@article {3705,
	title = {Substitution reaction mechanisms of dihydrido-ruthenium(II) phosphine complexes: Hydride basicity and molecular hydrogen intermediates},
	journal = {Inorganica Chimica Acta},
	volume = {250},
	number = {1-2},
	year = {1996},
	note = {ISI Document Delivery No.: VV296Times Cited: 8Cited Reference Count: 43},
	month = {Sep},
	pages = {351-357},
	type = {Article},
	abstract = {{Kinetic and activation parameter data for the reactions of cct-Ru(H)(2)(CO)(2)(PPh(3))(2) (1) (cct = cis, cis, trans) in THF with thiols, CO and PPh(3) to give cct-RuH(SR)(CO)(2)(PPh(3))(2), Ru(CO)(3)(PPh(3))(2) and Ru(CO)(2)(PPh(3))(2), respectively, reveal a common, rate-determining step, the initial dissociation of H-2 from 1; the activated complex probably resembles the corresponding Ru(eta(2)-H-2) species. Reaction of Ru(H)(2)(dppm)(2) (2) (as a cis/trans mixture},
	keywords = {ACIDITY, CATALYSIS, dihydrogen complexes, ETA-2-DIHYDROGEN COMPLEXES, hydride complexes, HYDRODESULFURIZATION, iron, kinetics and mechanism, MERCAPTO, molecular hydrogen complexes, ruthenium, ruthenium complexes, SPECTRA, sulfide},
	isbn = {0020-1693},
	url = {<Go to ISI>://A1996VV29600040},
	author = {Jessop, P. G. and Rastar, G. and James, Brian R.}
}
@article {3272,
	title = {The kinetics and energetics of formation of a molecular hydrogen complex involving a dinuclear ruthenium(II) centre},
	journal = {Inorganica Chimica Acta},
	volume = {240},
	number = {1-2},
	year = {1995},
	note = {ISI Document Delivery No.: TV742Times Cited: 9Cited Reference Count: 32},
	month = {Dec},
	pages = {419-425},
	type = {Article},
	abstract = {The reversible equilibrium conversion under H-2 of [RuCl(dppb) (mu-Cl)](2) (1) to generate (eta(2)-H-2) (dppb) (mu-Cl)(3)RUCl( dppb) in CH2Cl2 (dppb = Ph(2)P(CH2)(4)PPh(2)) has been studied at 0-25 degrees C by UV-Vis and (31)p{H-1} NMR spectroscopy, and by stopped-how kinetics; the equilibrium constant and corresponding thermodynamic parameters, and the forward and reverse rate constants at 25 degrees C have been determined. A measured Delta H degrees value of similar to 0 kj mol(-1) allows for an estimation of an exothermicity of similar to 60 kj mol(-1) for binding an eta(2)-H-2 at an Ru(II) centre; a Delta S degrees value of similar to 60 J mol(-1) K-1 indicates that in solution 1 contains coordinated CH2Cl2. The kinetic and thermodynamic data are compared to those obtained from a previously studied hydrogenation of styrene catalyzed by 1. Preliminary findings on related systems containing Ph(2)P(CH2)(3)PPh(2) and (C6H11)(2)P(CH2)(4)P(C6H11)(2) are also noted.},
	keywords = {BINDING, DERIVATIVES, DIHYDROGEN, dihydrogen complexes, LIGANDS, MECHANISTIC ASPECTS, NITROGEN, PHOSPHINE COMPLEXES, ruthenium complexes, SELECTIVE HYDROGENATION},
	isbn = {0020-1693},
	url = {<Go to ISI>://A1995TV74200054},
	author = {Chau, Deky and James, Brian R.}
}
@article {3320,
	title = {NET AMINE DEALKYLATION AT A DIRUTHENIUM CENTER - DEHYDROGENATION OF A SECONDARY AMINE AND HYDROLYSIS OF A COORDINATED IMINE},
	journal = {Inorganic Chemistry},
	volume = {34},
	number = {10},
	year = {1995},
	note = {ISI Document Delivery No.: QX706Times Cited: 26Cited Reference Count: 36},
	month = {May},
	pages = {2557-2561},
	type = {Article},
	abstract = {Reaction of excess benzylamine with Ru2Cl4(dppb)(2) (1) or RuCl2(dppb)(PPh(3)) (2) under Ar or with Ru2Cl5(dppb)(2) (3) under H-2 or in air generates RuCl2(dppb)(NH(2)CH(2)Ph)(2) [dppb = 1,4-bis(diphenylphosphino)butane, Ph(2)P(CH2)(4)PPh(2)]. Use of 1 equiv of amine per [Ru(II)](2) gives dinuclear Ru2Cl4(dppb)(2)(NH(2)CH(2)Ph) (4a) as a mixture of isomers. The corresponding reactions with dibenzylamine yield only dinuclear products: either Ru2Cl4(dppb)(2)[NH(CH(2)Ph)(2)] (4b), for reactions under H-2, or a mixture of this species and the dealkylation product 4a. The mechanism proposed for formation of the latter involves dehydrogenation of the secondary amine adduct to Ru2Cl4(dppb)(2)[PhCH(2)N=C(H)Ph], followed by hydrolysis of the coordinated imine. Direct reaction of PhCH(2)N=C(H)Ph with 3 under H-2 permits isolation of solely 4b. The findings are of interest also in context of thermal degradation of tertiary amines and hydrogenation of imines catalyzed by Ru ditertiary phosphine complexes.},
	keywords = {ACTIVATION, CATALYSTS, COMPLEXES, CONVERSION, CRYSTAL-STRUCTURE, DIHYDROGEN, PHOSPHINE COMPLEXES, PORPHYRIN, REACTIVITY, ruthenium complexes, TERTIARY-AMINES},
	isbn = {0020-1669},
	url = {<Go to ISI>://A1995QX70600012},
	author = {Fogg, D. E. and James, Brian R.}
}
@article {3241,
	title = {RUTHENIUM COMPLEXES CONTAINING TERTIARY PHOSPHINES AND IMIDAZOLE OR 2,2{\textquoteright}-BIPYRIDINE LIGANDS},
	journal = {Inorganica Chimica Acta},
	volume = {230},
	number = {1-2},
	year = {1995},
	note = {ISI Document Delivery No.: QN719Times Cited: 26Cited Reference Count: 39},
	month = {Mar},
	pages = {111-117},
	type = {Article},
	abstract = {{Complexes RuCl3(PPh(3))L(2) (L=MeIm (1a), Im (1b)) and [RuCl2(PPh(3))(2)(bipy)]Cl . 4H(2)O (2) have been synthesized via the ruthenium(III) precursor RuCl3(PPh(3))(2) (DMA), and characterized, including an X-ray structural analysis for 1a (MeIm=N-methylimidazole},
	keywords = {BIPYRIDINE COMPLEXES, CRYSTAL, crystal structures, DERIVATIVES, HYDROGEN, IMIDAZOLE COMPLEXES, ruthenium complexes, TERTIARY PHOSPHINE COMPLEXES, X-ray structure},
	isbn = {0020-1693},
	url = {<Go to ISI>://A1995QN71900015},
	author = {Batista, A. A. and Polato, E. A. and Queiroz, S. L. and Nascimento, O. R. and James, Brian R. and Rettig, S. J.}
}
@article {3028,
	title = {A COMPARISON OF CATALYTIC ACTIVITY FOR IMINE HYDROGENATION USING RU DITERTIARY PHOSPHINE COMPLEXES, INCLUDING CHIRAL SYSTEMS},
	journal = {Inorganica Chimica Acta},
	volume = {222},
	number = {1-2},
	year = {1994},
	note = {ISI Document Delivery No.: PD174Times Cited: 39Cited Reference Count: 45},
	month = {Jul},
	pages = {85-90},
	type = {Article},
	abstract = {A family of ruthenium ditertiary phosphine complexes was investigated for catalytic activity toward imine hydrogenation. The diphosphines (PP) used include chiral (chiraphos, diop, binap) and achiral (dppe, dppb) systems (chiraphos = Ph2PCH(Me)CH(Me)PPh2; diop = Ph2PCH2CHOCMe2OCHCH2PPh2; binap = 2,2{\textquoteright}-bis(diphenylphosphino)-1,1{\textquoteright}-binaphthyl; Ph2P(CH2)(n)PPh2 (n = 2, dppe; n = 4, dppb)). Activity was observed in MeOH at low catalyst concentrations (0.77 mM Ru), under moderate conditions (room temperature (r.t.), 1000 psi H2). The air-stable Ru2Cl5(PP)2 complexes were more active than the commonly used dimeric Ru2(II,II) systems to which they give rise in situ. Asymmetric induction in the prochiral ketimine PhCH2N = C(Me)Ph was consistent, though modest, within the diop and binap series of neutral complexes, implying a common catalytic intermediate within each series. A maximum e.e. of 27\% was found using Ru2Cl5(chiraphos)2 as catalyst; this represents a non-optimized figure for asymmetric induction, as no other prochiral ketimines were screened.},
	keywords = {1{\textquoteright}-BINAPHTHYL, 2, 2{\textquoteright}-BIS(DIPHENYLPHOSPHINO)-1, ACIDS, ASYMMETRIC HYDROGENATION, BINAP, CATALYSIS, DIPHOSPHINE, ENANTIOSELECTIVE, HYDROGENATION, IMINE HYDROGENATION, LIGANDS, NITRILE COMPLEXES, PHOSPHINE COMPLEXES, ruthenium complexes, X-ray structure},
	isbn = {0020-1693},
	url = {<Go to ISI>://A1994PD17400011},
	author = {Fogg, D. E. and James, Brian R. and Kilner, M.}
}
