@article {2163,
	title = {Cross-metathesis of the vinyl group, on tetrapyrrolic macrocycles: Reactivity, selectivity, and mechanism},
	journal = {Journal of Organic Chemistry},
	volume = {73},
	number = {17},
	year = {2008},
	note = {ISI Document Delivery No.: 344EDTimes Cited: 3Cited Reference Count: 32Liu, Xin Sternberg, Ethan Dolphin, David},
	month = {Sep},
	pages = {6542-6550},
	type = {Article},
	abstract = {To find a general strategy for modifying the peripheral structure of vinylchlorin and porphyrin substrates, cross-metathes is on the vinyl group of these tetrapyrrolic macrocycles was investigated. The N-heterocyclic carbene-containing ruthenium complex 3 efficiently catalyzed the cross-metathes is (CM) of vinylchlorins and vinylporphyrins with a variety of olefins in high E-stereoselectivity. Different substituents on the olefin dramatically influenced the reaction. While the chlorins were more reactive than the porphyrins (as free bases), the corresponding zinc complexes showed higher activity. The reaction mechanism was investigated, and an empirical model for selective CM was applied to our studies to direct further reactions.},
	keywords = {A DERIVATIVES, CATALYSTS, chlorins, OLEFIN METATHESIS, PHOTODYNAMIC THERAPY, PHOTOSENSITIZERS, RUCL2(=CHR)(PR(3))(2)},
	isbn = {0022-3263},
	url = {<Go to ISI>://000258908000009},
	author = {Liu, X. and Sternberg, E. and Dolphin, D.}
}
@article {376,
	title = {Carbonyl ylide 1,3-dipolar cycloadditions with porphyrins},
	journal = {Tetrahedron Letters},
	volume = {43},
	number = {40},
	year = {2002},
	note = {ISI Document Delivery No.: 594JVTimes Cited: 30Cited Reference Count: 10},
	month = {Sep},
	pages = {7281-7283},
	type = {Article},
	abstract = {Carbonyl ylides react with tetraarylporphyrins to afford the corresponding [3+2] tetrahydrofuran cycloaddition products in moderate yields. (C) 2002 Published by Elsevier Science Ltd.},
	keywords = {carbonyl ylide, chlorins, cycloadditions, porphyrins},
	isbn = {0040-4039},
	url = {<Go to ISI>://000178047100038},
	author = {Flemming, J. and Dolphin, D.}
}
@article {435,
	title = {Evaluation of tetraphenyl-2,3-dihydroxychlorins as potential photosensitizers},
	journal = {Journal of Porphyrins and Phthalocyanines},
	volume = {6},
	number = {2},
	year = {2002},
	note = {ISI Document Delivery No.: 595XYTimes Cited: 15Cited Reference Count: 33},
	pages = {146-155},
	type = {Article},
	abstract = {A series of beta,beta-dihydroxychlorins derived from meso-tetraphenylporphyrins (TPPs) have been synthesized. Their in vitro cytotoxicity has been measured and compared to BPDMA (verteporfin). Under the assay conditions BPDMA had an LD50 (lethal dose to kill 50\% of cells) value of 0.007 muM (5 ng/mL). The LD50 values for the TPP derivatives varied from 1.7 x 10(-2) to 9.9 muM depending upon the substituents and their position on the phenyl groups. One example of the dihydroxychlorin prepared from unsubstituted 5,15-diphenylporphyrin was examined and this exhibited an LD50 of 2.4 x 10(-3) muM! Copyright (C) 2002 Society of Porphyrins \& Phthalocyanines.},
	keywords = {AGGREGATION, BACTERIOCHLORINS, beta, beta-dihydroxychlorins, BIODISTRIBUTION, chlorins, cytotoxicity, DERIVATIVES, photodynamic, PHOTODYNAMIC THERAPY, PHOTOPHYSICAL PROPERTIES, PHOTOSENSITIZERS, porphyrins, PROTEIN-BINDING, SENSITIZERS, therapy, TUMOR PHOTOSENSITIZERS},
	isbn = {1088-4246},
	url = {<Go to ISI>://000178134600008},
	author = {Macalpine, J. K. and Boch, R. and Dolphin, D.}
}
@article {4063,
	title = {Chemical modification of chlorophyll a: Synthesis of new regiochemically pure benzoporphyrin and dibenzoporphyrin derivatives},
	journal = {Canadian Journal of Chemistry-Revue Canadienne De Chimie},
	volume = {75},
	number = {3},
	year = {1997},
	note = {ISI Document Delivery No.: XD813Times Cited: 10Cited Reference Count: 28},
	month = {Mar},
	pages = {262-275},
	type = {Article},
	abstract = {Starting from pheophorbide a methyl ester (5), a degradation product of chlorophyll a, routes for the preparation of 3-vinylporphyrins 6 and 9 and of an [A,C]-divinylporphyrin 16 are described. These porphyrins were obtained as a result of chemical modification of 5 on ring D and the exocyclic ring E. Diels-Alder reactions of these (di)vinylporphyrins with dimethyl acetylenedicarboxylate, to afford new regiochemically pure benzoporphyrin derivatives 29 and 30 and dibenzoporphyrin derivative 33 for potential use as sensitizers in photodynamic therapy of tumors, were also investigated.},
	keywords = {(di)benzoporphyrins, (di)vinylporphyrins, chlorins, CHLOROPHYLL, CONVERSION, Diels-Alder, ESTERS, photodynamic, PHOTODYNAMIC THERAPY, ROUTE, therapy},
	isbn = {0008-4042},
	url = {<Go to ISI>://A1997XD81300003},
	author = {Ma, L. F. and Dolphin, D.}
}
@article {3262,
	title = {2,3-VIC-DIHYDROXY-MESO-TETRAPHENYLCHLORINS FROM THE OSMIUM-TETROXIDE OXIDATION OF MESO-TETRAPHENYLPORPHYRIN},
	journal = {Tetrahedron Letters},
	volume = {36},
	number = {19},
	year = {1995},
	note = {ISI Document Delivery No.: QY111Times Cited: 34Cited Reference Count: 25},
	month = {May},
	pages = {3295-3298},
	type = {Article},
	abstract = {meso-Tetraphenylporphyrins and meso-tetraphenylmetalloporphyrins were converted into stable 2,3-vic-dihydroxy-meso-tetraphenylchlorins and 2,3-vic-dihydroxy-meso-tetraphenylmetallochlorins by oxidation with stoichiometric amounts of OsO4 and subsequent reduction of the isolable osmate esters. The stable dihydroxychlorins were dehydrated under acid catalysis to yield 2-hydroxy-meso-tetraphenylporphyrins.},
	keywords = {BACTERIOCHLORINS, chlorins, EFFICIENT SYNTHESIS, PHOTODYNAMIC THERAPY, porphyrins, TUMOR PHOTOSENSITIZERS},
	isbn = {0040-4039},
	url = {<Go to ISI>://A1995QY11100002},
	author = {Bruckner, C. and Dolphin, D.}
}
