@article {WANG2024139004,
	title = {Strategies for using magnetic beads in enhanced deep eutectic solvent-mechanochemical extraction of natural products from orange peels},
	journal = {Food Chemistry},
	volume = {447},
	year = {2024},
	pages = {139004},
	abstract = {To address the challenges of low recovery, prolonged extraction times, and environmental pollution caused by toxic solvents in traditional extraction methods, magnetic bead-enhanced deep eutectic solvent mechanochemical extraction was developed for extracting natural products from orange peels. The extraction efficiencies of deep eutectic solvents were experimentally evaluated, and theoretical methods were used to guide solvent selection. Choline chloride-ethylene glycol demonstrated the highest efficiency under the optimal extraction conditions: a molar ratio of 1:2, no water content, a solid-liquid ratio of 0.08~g/mL, and an extraction time of 60~s. The synergy between the deep eutectic solvent and magnetic bead-enhanced the mechanochemical extraction efficiencies. The study also examined the effects of different magnetic bead types and orange peel powder particle sizes on extraction efficiency, finding that a 0.11~mm particle size combined with CIP@SiO2 yielded the best results. Overall, this study holds promise as an environmentally friendly and efficient extraction method.},
	keywords = {Deep eutectic solvents, Hydrogen bond donors and acceptors, Magnetic beads, Mechanochemical extraction, natural products, Orange peel},
	issn = {0308-8146},
	doi = {https://doi.org/10.1016/j.foodchem.2024.139004},
	url = {https://www.sciencedirect.com/science/article/pii/S0308814624006538},
	author = {Zhaoyang Wang and Wuxia Ge and Wentao Bi and David Da Yong Chen}
}
@article {2183,
	title = {Intraannular Savige-Fontana reaction: One-step conversion of one class of monocyclic peptides into another class of bicyclic peptides},
	journal = {Chemistry-a European Journal},
	volume = {14},
	number = {11},
	year = {2008},
	note = {ISI Document Delivery No.: 291XITimes Cited: 1Cited Reference Count: 34May, Jonathan P. Perrin, David M.},
	pages = {3404-3409},
	type = {Article},
	abstract = {Cyclisation and cross-linking strategies are important for the synthesis of cyclic and bicyclic peptides. These macrolactams are of great interest due to their increased biological activity compared to linear analogues. Herein, we describe the synthesis of a cyclic peptide containing an Hpi toxicophore, reminiscent of phakellistatins and omphalotins. The first intraannular cross-linking of such a peptide is then presented: using neat TFA to catalyse a Savige-Fontana tryptathionylation, the Hpi-containing peptide is converted to a bicyclic amatoxin analogue. As such, this methodology represents an efficient cyclisation method for cross-linking peptides and exposes a heretofore unrealised relationship between two different classes of peptide natural products. This finding increases the degree of potential chemical space for library generation.},
	keywords = {2-CHLOROTRITYL CHLORIDE, 2-THIOETHER DERIVATIVES, amatoxin, ANALOGS, CROSS-LINKING, CYSTEINE SULFHYDRYL-GROUPS, ILE3-AMANINAMIDE, indole, ISOPHAKELLISTATIN-3, natural products, OXIDATION, PEPTIDES, PHALLOTOXINS, RNA POLYMERASE-II, TRYPTOPHAN},
	isbn = {0947-6539},
	url = {<Go to ISI>://000255230200019},
	author = {May, J. P. and Perrin,David M.}
}
@article {935,
	title = {Stereochemical assignment in acyclic lipids across long distance by circular dichroism: Absolute stereochemistry of the aglycone of caminoside A},
	journal = {Angewandte Chemie-International Edition},
	volume = {43},
	number = {44},
	year = {2004},
	note = {ISI Document Delivery No.: 874FTTimes Cited: 14Cited Reference Count: 30},
	pages = {5946-5951},
	type = {Article},
	keywords = {AGENT, ANTIVIRAL ANTIBIOTICS, B-1, CHROMOPHORES, circular dichroism, CONFIGURATION ANALYSIS, CYCLOVIRACIN, glycolipids, LIPOSOMES, MOSHER METHOD, natural products, NMR, PHYSICOCHEMICAL, PROPERTIES, SECONDARY ALCOHOLS, SPIN-COUPLING CONSTANTS, STEREOCHEMISTRY},
	isbn = {1433-7851},
	url = {<Go to ISI>://000225337000017},
	author = {MacMillan, J. B. and Linington, R. G. and Andersen, R. J. and Molinski, T. F.}
}
@article {642,
	title = {Anticancer agents from unique natural products sources},
	journal = {Pharmaceutical Biology},
	volume = {41},
	year = {2003},
	note = {ISI Document Delivery No.: 877RKTimes Cited: 5Cited Reference Count: 8344th Annual Meeting of the American-Society-of-PharmacognosyJUL 12-16, 2003Chapel Hill, NCAmer Soc PharmacognosySuppl. S},
	pages = {15-38},
	type = {Proceedings Paper},
	abstract = {The National Cooperative Natural Products Drug Discovery Group (NCNPDDG) "Anticancer Agents from Unique Natural Products Sources, CA 67786" was first awarded in September 1995. The goal of the project is to discover and develop novel anticancer agents from a variety of natural products sources. The key accomplishments of this NCDDG which will be highlighted in this manuscript include: Development of tools to probe fungi for the production of novel natural products by DNA-based probes. Discovery that the majority of these fungi can produce natural products via nonribosomal peptide synthetases, polyketide synthases, or both - a much larger percentage than current culturing techniques reveal. Identification of the MDR-selective cytotoxic agent austocystin D, and use of a novel yeast deletion strain approach to help identify its molecular target(s). Identification of hemiasterlin and other naturally occurring analogs as potent antimitotic agents with excellent in vivo activity against human solid tumors in mouse models. Development of a total synthesis of hemiasterlin. The utilization of this methodology to provide the first SAR for the hemiasterlin family of antimitotic agents and to identify the synthetic analog HTI-286, which is being examined in clinical trials as an anticancer agent. To provided technology transfer, educational opportunities and compensation to countries of origin for collection and study of their natural product resources. This NCNPDDG program has provided funding to research programs at the University of the Philippines, The University of the South Pacific in the Fiji Islands, Colombo University in Sri Lanka, the Instituto de Quimica de Sao Carlos, Universidade de Sao Paulo, Brazil, and the University of Papua New Guinea.},
	keywords = {ACTIVATED PROTEIN-KINASE, antitumor agents, austocystins, CYCLIN-DEPENDENT KINASES, CYTOTOXIC PEPTIDES, fungi, GROWTH-FACTOR RECEPTOR, hemiasterlins, IN-VIVO, LINKED-IMMUNOSORBENT-ASSAY, MARINE, MICROORGANISMS, MULTIDRUG-RESISTANCE, natural products, NCDDG, sponges, TRIPEPTIDE HEMIASTERLIN, TUMOR-CELL LINES, TYROSINE KINASE},
	isbn = {1388-0209},
	url = {<Go to ISI>://000225587500004},
	author = {Ireland, C. M. and Aalbersberg, W. and Andersen, R. J. and Ayral-Kaloustian, S. and Berlinck, R. G. S. and Bernan, V. and Carter, G. and Churchill, A. C. L. and Clardy, J. and Concepcion, G. P. and De Silva, E. D. and Discafani, C. and Fojo, T. and Frost, P. and Gibson, D. and Greenberger, L. M. and Greenstein, M. and Harper, M. K. and Mallon, R. and Loganzo, F. and Nunes, M. and Poruchynsky, M. S. and Zask, A.}
}
@article {749,
	title = {Briarane, erythrane, and aquariane diterpenoids from the Caribbean gorgonian Erythropodium caribaeorum},
	journal = {European Journal of Organic Chemistry},
	number = {18},
	year = {2003},
	note = {ISI Document Delivery No.: 726HFTimes Cited: 5Cited Reference Count: 15},
	month = {Sep},
	pages = {3515-3523},
	type = {Article},
	abstract = {Seven new diterpenoids belonging to the briarane [erythrolides R (5), S (6), T (7), and U (8)], erythrane [erythrolide V (9)], and aquariane [aquariolides B (10) and C (11)] skeletal classes have been isolated from the encrusting gorgonian Erythropodium caribaeorum. The structures of the new compounds were elucidated by spectroscopic analysis and chemical interconversions. A biogenetic proposal that links carbon skeletons found in E. caribaeorum diterpenoids is presented. (C) Wiley-VCH Verlag GmbH Co.},
	keywords = {asymmetric, bioorganic chemistry, ELEUTHEROBIN, ERYTHROLIDES, natural products, structure elucidation, SYNTHESIS, terpenoids},
	isbn = {1434-193X},
	url = {<Go to ISI>://000185592300005},
	author = {Taglialatela-Scafati, O. and Craig, K. S. and Reberioux, D. and Roberge, M. and Andersen, R. J.}
}
