@article {5046,
	title = {Aggregation studies of benzoporphyrin derivative},
	journal = {Canadian Journal of Chemistry-Revue Canadienne De Chimie},
	volume = {79},
	number = {5-6},
	year = {2001},
	note = {ISI Document Delivery No.: 456EVTimes Cited: 11Cited Reference Count: 33},
	month = {May},
	pages = {1068-1074},
	type = {Article},
	abstract = {The photophysical properties of a ring B benzoporphyrin derivative 1,3-diene dimethylester were investigated in solution (water-DMSO mixtures). At low proportions of water in DMSO, the diester obeys Beer{\textquoteright}s law at all pH values and ionic strengths investigated. For solvent systems containing more than 30\% water, the extent of deviation from Beer{\textquoteright}s law as a function of porphyrin concentration is attributed to formation of porphyrin dimers. Dimerization equilibrium constants (Kd) have been determined in different percentage of solvent mixtures, using absorption and fluorescence spectroscopies, and were found to exhibit a linear correlation between log (Kd) and the inverse of the dielectric constant (log (Kd) = 24.6 - 1060.4 x 1/epsilon (mix)). This equation permits the calculation of Kd in mixtures of water-DMSO.},
	keywords = {AGGREGATION, benzoporphyrin, BPD, DERIVATIVE, DIMERIZATION, FLUORESCENCE, PHOTODYNAMIC THERAPY, PHOTOSENSITIZERS, porphyrins, SPECTROSCOPY, therapy},
	isbn = {0008-4042},
	url = {<Go to ISI>://000170070900079},
	author = {Delmarre, D. and Hioka, N. and Boch, R. and Sternberg, E. and Dolphin, D.}
}
@article {4089,
	title = {Application of long-circulating liposomes to cancer photodynamic therapy},
	journal = {Biological \& Pharmaceutical Bulletin},
	volume = {20},
	number = {6},
	year = {1997},
	note = {ISI Document Delivery No.: XG547Times Cited: 26Cited Reference Count: 30},
	month = {Jun},
	pages = {670-673},
	type = {Article},
	abstract = {Photodynamic therapy (PDT) as a cancer treatment is notable for its quite low side effects in comparison with those of chemotherapy and radiotherapy. However, the accumulation of porphyrin derivatives used in PDT into tumor tissues is rather low. Since long-circulating liposomes are known to accumulate passively into tumor tissues, we liposomalized a porphyrin derivative, benzoporphyrin derivative monoacid ring A (BPD-MA), and used these liposomes to investigate the usefulness of PDT for tumor-bearing mice. BPD-MA was liposomalized into glucuronate-modified liposomes, which are known to be long-circulating. These liposomes were injected i.v. into Balb/c mice bearing Meth A sarcoma, and tumor regression and survival time were monitored after irradiation with laser light. Tumor regression and complete curing of tumor (80\% cure rate by the treatment with 6 mg/kg BPD-R?IA) were observed when long circulating liposomalized BPD-MA was injected and laser-irradiated. In contrast, only a 20\% cure rate was obtained when the animals were treated with BPD-MA solution or BPD-MA entrapped in conventional liposomes. These results suggest that a long-circulating liposomal formulation of photo-sensitive agents is useful for PDT.},
	keywords = {BEARING MICE, benzoporphyrin, BENZOPORPHYRIN DERIVATIVES, BPD, CELLS, DERIVATIVE, drug delivery system, EFFICACY, INVIVO, LIPOPROTEINS, liposome, MURINE TUMOR-MODEL, PHOTODYNAMIC THERAPY, PHOTOSENSITIZER, time},
	isbn = {0918-6158},
	url = {<Go to ISI>://A1997XG54700016},
	author = {Oku, N. and Saito, N. and Namba, Y. and Tsukada, H. and Dolphin, D. and Okada, S.}
}
