@article {4411,
	title = {Porphyrin-based photosensitizers for use in photodynamic therapy},
	journal = {Tetrahedron},
	volume = {54},
	number = {17},
	year = {1998},
	note = {ISI Document Delivery No.: ZF569Times Cited: 379Cited Reference Count: 376},
	month = {Apr},
	pages = {4151-4202},
	type = {Review},
	keywords = {(+/-)-BONELLIN DIMETHYL ESTER, ALGA, BLOOD PIGMENT HEME, CHLORIN, CHLOROPHYLL DERIVATIVES, E6 NPE6, EFFICIENT SYNTHESIS, HIGH-YIELD SYNTHESIS, NICKEL BETA-OXOPORPHYRINS, PHOTOFRIN-II, SUBSTITUTED PORPHYRINS, TOLYPOTHRIX-NODOSA},
	isbn = {0040-4020},
	url = {<Go to ISI>://000072910600001},
	author = {Sternberg, E. D. and Dolphin, D. and Bruckner, C.}
}
@article {3825,
	title = {Pyrrolic photosensitizers},
	journal = {Current Medicinal Chemistry},
	volume = {3},
	number = {4},
	year = {1996},
	note = {ISI Document Delivery No.: VE317Times Cited: 21Cited Reference Count: 172},
	month = {Aug},
	pages = {239-272},
	type = {Review},
	abstract = {There are three major classes of photosensitizers which can initiate a phototoxic effect to tissues upon irradiation. These are the cationic dyes (Type I Photosensitizer), the psoralens (Type I and II Photosensitizer), and cyclic polypyrrolic compounds (Type II Photosensitizer). The polypyrrolic compounds such as porphyrins have been investigated since the late 1800{\textquoteright}s for their ability to destroy tissue. In the last ten years, compounds such as chlorins and expanded porphyrins have begun to dominate the preclinical field because they can be activated with light at wavelengths tissue does not effectively absorb. The results of these investigation have been reported in more than 10,000 papers in the field covering aspects from mechanisms of action, photophysics, structure activity relationships, new compound development and clinical investigations. With the approval of PHOTOFRIN(R), (porfimer sodium), the first of the pyrrolic compounds to win acceptance by international regulatory bodies and with nearly 10 other second generation compounds undergoing early clinical trials for diseases ranging from esophageal and skin cancers to age related macular degeneration, the field of photodynamic therapy would seem to have a bright future.},
	keywords = {BENZOPORPHYRIN DERIVATIVES, capillary electrophoresis, ENDOGENOUS, M-THPC, MOUSE-TUMOR MODEL, PHOTODYNAMIC THERAPY, PHOTOFRIN-II, PLASMA-LIPOPROTEINS, PROTOPORPHYRIN, RING-A BPD, TISSUE DISTRIBUTION},
	isbn = {0929-8673},
	url = {<Go to ISI>://A1996VE31700002},
	author = {Sternberg, E. and Dolphin, D.}
}
@article {7102,
	title = {PHOTOSENSITIZING POTENCY OF STRUCTURAL ANALOGS OF BENZOPORPHYRIN DERIVATIVE (BPD) IN A MOUSE-TUMOR MODEL},
	journal = {British Journal of Cancer},
	volume = {63},
	number = {1},
	year = {1991},
	note = {ISI Document Delivery No.: ER853Times Cited: 85Cited Reference Count: 19},
	month = {Jan},
	pages = {87-93},
	type = {Article},
	abstract = {The in vivo characteristics of four analogues of benzoporphyrin derivative (BPD) have been investigated. Biodistribution data obtained in DBA/2J mice with BPD-MA (monoacid ring A analogue) which had been tritiated or internally labelled with C-14 showed that both labelled materials acted in an essentially identical manner during the period of study. Biodistribution and clearance studies showed that relative distribution in a variety of mouse tissues was similar for all BPD analogues. M1 tumour cells (rhabdomyosarcoma in DBA/2J mice) taken from tumours excised from animals treated 3 h earlier with BPD, and tested in vitro for photosensitivity provided evidence that significant levels of photosensitiser detected in tumour was both active and associated with tumour cells. The monoacid forms of BPD were found to be much more photodynamically active in this test that were the diacid analogues. The ability of the analogues to ablate tumours in mice by photodynamic therapy was also tested. Again, BPD-MA and BPD-MB proved to be measurably better than the diacid analogues. These findings are discussed in reference to structural and physical differences between the analogues.},
	keywords = {HEMATOPORPHYRIN, PHOTOFRIN-II, PHTHALOCYANINES, PLASMA-LIPOPROTEINS, porphyrins, TOXICITY},
	isbn = {0007-0920},
	url = {<Go to ISI>://A1991ER85300018},
	author = {Richter, A. M. and Waterfield, E. and Jain, A. K. and Allison, B. and Sternberg, E. D. and Dolphin, D. and Levy, J. G.}
}
