@article {572,
	title = {New okadaic acid analogues from the marine sponge Merriamum oxeato and their effect on mitosis},
	journal = {Journal of Natural Products},
	volume = {66},
	number = {6},
	year = {2003},
	note = {ISI Document Delivery No.: 695CYTimes Cited: 4Cited Reference Count: 25},
	month = {Jun},
	pages = {838-843},
	type = {Article},
	abstract = {Inhibitors of the G2 DNA damage checkpoint can selectively sensitize cancer cells with impaired p53 tumor suppressor activity to killing by DNA-damaging drugs or ionizing radiation and have been proposed as a promising therapeutic strategy. An extract from the Northeastern Pacific marine sponge Merriamum. oxeato showed G2 checkpoint inhibitory activity, and fractionation identified the known dinoflagellate toxin dinophysistoxin 1 (1) and the two novel analogues 27-O-acetylokadaic acid (2) and 27-O-acetyldinophysistoxin 1 (3) as the active compounds. The mixture of 1, 2, and 3 was extremely potent at inhibiting the G2 checkpoint (IC50 = 1 ng/mL) and cellular protein Ser/Thr phosphatases (IC50 = 1 ng/mL), and it radiosensitized MCF-7 breast cancer cells expressing mutated p53 at all concentrations tested. However, the mixture of 1, 2, and 3 was also very toxic to cells not exposed to DNA damage (IC50 = 1 ng/mL), making these compounds poor candidates for therapeutic agents to augment the effectiveness of DNA-damaging therapies.},
	keywords = {CELL-CYCLE CHECKPOINTS, DNA-DAMAGE CHECKPOINT, ELUCIDATION, INHIBITION, ISOGRANULATIMIDE, P53, PROTEIN-KINASES, TRANSFORMATION},
	isbn = {0163-3864},
	url = {<Go to ISI>://000183814600019},
	author = {Britton, R. and Roberge, M. and Brown, C. and Van Soest, R. and Andersen, R. J.}
}
@article {678,
	title = {Template effect where 1-3 molecules drive formation of a trimer carceplex},
	journal = {Chemistry-a European Journal},
	volume = {9},
	number = {14},
	year = {2003},
	note = {ISI Document Delivery No.: 706XATimes Cited: 6Cited Reference Count: 46},
	month = {Jul},
	pages = {3253-3262},
	type = {Article},
	abstract = {The template effect in the formation of a trimer carceplex using 1-3 molecules as templates is explored. Thirteen different templates were studied and template ratios were measured for templates of like and unlike molecularity. Five transition-state models were studied for their binding abilities to see if these mirror the template ratios. The chemical shifts of the guests and the thermodynamic and kinetic values for templation suggest that binding is key, often tight, and that the guest determining step is formation of the last covalent bond. The molecular dynamics of guests as well as the conformational dynamics of both hosts and guests further addresses nature of the recognition between host and guest. Finally, we were surprised to discover that water can bind reversibly to the trimer carceplexes, which will have ramifications to any inner phase reactions conducted inside the cage.},
	keywords = {AMPLIFICATION, BARRIER, BINDING, CAPTURE, carceplex, CHEMISTRY, DIELS-ALDER REACTION, DYNAMICS, ELUCIDATION, ENCAPSULATION, HOST-GUEST COMPLEXATION, host-guest systems, molecular recognition, RESORCINARENE CAPSULE, REVERSIBLE, supramolecular, TEMPLATE SYNTHESIS},
	isbn = {0947-6539},
	url = {<Go to ISI>://000184479300009},
	author = {Makeiff, D. A. and Sherman, J. C.}
}
@article {3597,
	title = {Cationic iridium(III) carbonyl complexes: [Ir(CO)(6)](3+) and [Ir(CO)(5)Cl](2+)},
	journal = {Angewandte Chemie-International Edition in English},
	volume = {35},
	number = {17},
	year = {1996},
	note = {ISI Document Delivery No.: VM029Times Cited: 55Cited Reference Count: 27},
	month = {Sep},
	pages = {1974-1976},
	type = {Article},
	keywords = {carbonyl complexes, ELUCIDATION, FLUOROSULFATE, IR spectroscopy, iridium compounds, MOLECULAR-STRUCTURE, MONOXIDE, SPECTRA, STRUCTURE, UNDECAFLUORODIANTIMONATE(V)},
	isbn = {0570-0833},
	url = {<Go to ISI>://A1996VM02900023},
	author = {Bach, C. and Willner, H. and Wang, C. Q. and Rettig, S. J. and Trotter, J. and Aubke, F.}
}
@article {3597,
	title = {Cationic iridium(III) carbonyl complexes: [Ir(CO)(6)](3+) and [Ir(CO)(5)Cl](2+)},
	journal = {Angewandte Chemie-International Edition in English},
	volume = {35},
	number = {17},
	year = {1996},
	note = {ISI Document Delivery No.: VM029Times Cited: 55Cited Reference Count: 27},
	month = {Sep},
	pages = {1974-1976},
	type = {Article},
	keywords = {carbonyl complexes, ELUCIDATION, FLUOROSULFATE, IR spectroscopy, iridium compounds, MOLECULAR-STRUCTURE, MONOXIDE, SPECTRA, STRUCTURE, UNDECAFLUORODIANTIMONATE(V)},
	isbn = {0570-0833},
	url = {<Go to ISI>://A1996VM02900023},
	author = {Bach, C. and Willner, H. and Wang, C. Q. and Rettig, S. J. and Trotter, J. and Aubke, F.}
}
