@article {572,
	title = {New okadaic acid analogues from the marine sponge Merriamum oxeato and their effect on mitosis},
	journal = {Journal of Natural Products},
	volume = {66},
	number = {6},
	year = {2003},
	note = {ISI Document Delivery No.: 695CYTimes Cited: 4Cited Reference Count: 25},
	month = {Jun},
	pages = {838-843},
	type = {Article},
	abstract = {Inhibitors of the G2 DNA damage checkpoint can selectively sensitize cancer cells with impaired p53 tumor suppressor activity to killing by DNA-damaging drugs or ionizing radiation and have been proposed as a promising therapeutic strategy. An extract from the Northeastern Pacific marine sponge Merriamum. oxeato showed G2 checkpoint inhibitory activity, and fractionation identified the known dinoflagellate toxin dinophysistoxin 1 (1) and the two novel analogues 27-O-acetylokadaic acid (2) and 27-O-acetyldinophysistoxin 1 (3) as the active compounds. The mixture of 1, 2, and 3 was extremely potent at inhibiting the G2 checkpoint (IC50 = 1 ng/mL) and cellular protein Ser/Thr phosphatases (IC50 = 1 ng/mL), and it radiosensitized MCF-7 breast cancer cells expressing mutated p53 at all concentrations tested. However, the mixture of 1, 2, and 3 was also very toxic to cells not exposed to DNA damage (IC50 = 1 ng/mL), making these compounds poor candidates for therapeutic agents to augment the effectiveness of DNA-damaging therapies.},
	keywords = {CELL-CYCLE CHECKPOINTS, DNA-DAMAGE CHECKPOINT, ELUCIDATION, INHIBITION, ISOGRANULATIMIDE, P53, PROTEIN-KINASES, TRANSFORMATION},
	isbn = {0163-3864},
	url = {<Go to ISI>://000183814600019},
	author = {Britton, R. and Roberge, M. and Brown, C. and Van Soest, R. and Andersen, R. J.}
}
@article {760,
	title = {Trisphaerolide A, a novel polyketide from the Dominican sponge Erylus trisphaerus},
	journal = {Journal of Natural Products},
	volume = {66},
	number = {4},
	year = {2003},
	note = {ISI Document Delivery No.: 673CVTimes Cited: 4Cited Reference Count: 14},
	month = {Apr},
	pages = {561-563},
	type = {Article},
	abstract = {The structure of trisphaerolide A (1), a mildly cytotoxic metabolite isolated from extracts of the marine sponge Erylus trisphaerus collected in Dominica, has been elucidated by detailed analysis of spectroscopic data. Trisphaerolide A (1) has a putative polyketide biogenesis, incorporating a rare variant on the standard pathway, which involves the addition of methyl branches arising from C-2 carbons of acetate units to chain carbons that arise from C-1 of acetate units.},
	keywords = {biosynthesis, CELL-CYCLE, DNA-DAMAGE CHECKPOINT, INHIBITION, ISOGRANULATIMIDE},
	isbn = {0163-3864},
	url = {<Go to ISI>://000182562800025},
	author = {van Altena, I. and Van Soest, R. and Roberge, M. and Andersen, R. J.}
}
@article {5023,
	title = {Granulatimide and 6-bromogranulatimide, minor alkaloids of the Brazilian ascidian Didemnum granulatum},
	journal = {Journal of Natural Products},
	volume = {64},
	number = {2},
	year = {2001},
	note = {ISI Document Delivery No.: 407DRTimes Cited: 16Cited Reference Count: 6},
	month = {Feb},
	pages = {254-255},
	type = {Article},
	abstract = {Reinvestigation of the extract of the ascidian Didemnum granulatum collected on the Brazilian coastline led to the isolation of two minor compounds, granulatimide (2) and 6-bromogranulatimide (3), which have been identified by analysis of their spectroscopic data. The isolation of 2 and 3 from D. granulatum corroborates previous assumptions about the occurrence of granulatimide as a natural product.},
	keywords = {ISOGRANULATIMIDE},
	isbn = {0163-3864},
	url = {<Go to ISI>://000167257100029},
	author = {Britton, R. and de Oliveira, Jhhl and Andersen, R. J. and Berlinck, R. G. S.}
}
@article {4982,
	title = {New diterpenoids from the octocoral Pachyclavularia violacea collected in Papua New Guinea},
	journal = {Tetrahedron},
	volume = {56},
	number = {46},
	year = {2000},
	note = {ISI Document Delivery No.: 371YWTimes Cited: 12Cited Reference Count: 13},
	month = {Nov},
	pages = {9031-9037},
	type = {Article},
	abstract = {Six new diterpenoids, pachyclavulariolides A (1) to F (6), with cembrane and briarane carbon skeletons have been isolated from specimens of Pachyclavularia violacea collected in Papua New Guinea. The structures of the new diterpenoids were elucidated by analysis of spectroscopic data. A single crystal X-ray diffraction analysis of pachyclavulariolide B (2) confirmed its structure. Pachyclavulariolide F (6) showed in vitro cytotoxicity. (C) 2000 Elsevier Science Ltd. All rights reserved.},
	keywords = {DITERPENOIDS, ISOGRANULATIMIDE, octocoral, Pachyclavularia violacea},
	isbn = {0040-4020},
	url = {<Go to ISI>://000165207700008},
	author = {Xu, L. and Patrick, B. O. and Roberge, M. and Allen, T. and van Ofwegen, L. P. and Andersen, R. J.}
}
