@article {2243,
	title = {Altering pyridinone N-substituents to optimise activity as potential prodrugs for Alzheimer{\textquoteright}s disease},
	journal = {Dalton Transactions},
	number = {45},
	year = {2008},
	note = {ISI Document Delivery No.: 371METimes Cited: 5Cited Reference Count: 29Scott, Lauren E. Page, Brent D. G. Patrick, Brian O. Orvig, Chris},
	pages = {6364-6367},
	type = {Article},
	abstract = {Selective design modifications of specifically substituted 3-hydroxy-4(1H)-pyridinones show possibly advantageous ring freedom while maintaining metal-binding ability and antioxidant capacity, moving toward an efficient potential treatment for Alzheimer{\textquoteright}s disease.},
	keywords = {aluminum, BLOOD-BRAIN-BARRIER, COMPLEXES, DISORDERS, DIVALENT, IRON CHELATORS, PENETRATION, STABILITIES, therapy, TRIVALENT METAL-IONS},
	isbn = {1477-9226},
	url = {<Go to ISI>://000260834600005},
	author = {Scott, L. E. and Page, B. D. G. and Patrick, B. O. and Orvig, Chris}
}
@article {3978,
	title = {Investigation of hydrogel formation from hydroxypropylmethylcellulose (HPMC) by NMR spectroscopy and NMR imaging techniques},
	journal = {Macromolecules},
	volume = {30},
	number = {20},
	year = {1997},
	note = {ISI Document Delivery No.: YA289Times Cited: 54Cited Reference Count: 21},
	month = {Oct},
	pages = {6230-6237},
	type = {Article},
	abstract = {NMR imaging has been used to investigate the in situ swelling behavior of 2-hydroxypropylmethylcellulose (HPMC) tablets in a sample geometry chosen for the simplicity of its diffusion behavior. Preliminary H-1 NMR spectroscopy experiments were performed on equilibrated mixtures of HPMC and water. From these, the dependence of the H-1 T-1 and T-2 relaxation parameters of the water protons with respect to HPMC weight percent were obtained. Further analysis of the T-2 values and H-1 z-spectroscopic data revealed that as the polymer concentration was increased from 10\% to 20\% w/w HPMC, the polymer mobility decreased substantially. One-dimensional NMR imaging of H-1 in the swelling tablet system was used to monitor the movement of water into the polymer and to calculate the T-2 parameters across the system. HPMC weight percents were calculated from these T-2 values using the previously determined calibration. HPMC distributions were determined for two tablet thicknesses. Similar swelling behavior was observed for both thicknesses at early times prior to the thinner tablet becoming completely hydrated.},
	keywords = {ABSORPTION, BEHAVIOR, DIFFUSION, DRUG-RELEASE, GEL LAYER, MECHANISMS, microscopy, PENETRATION, RELEASE DOSAGE FORMS, TABLETS},
	isbn = {0024-9297},
	url = {<Go to ISI>://A1997YA28900036},
	author = {Fyfe, C. A. and Blazek, A. I.}
}
