@article {388,
	title = {Transformation of arsenic(V) by the fungus Fusarium oxysporum melonis isolated from the alga Fucus gardneri},
	journal = {Applied Organometallic Chemistry},
	volume = {16},
	number = {12},
	year = {2002},
	note = {ISI Document Delivery No.: 622PGTimes Cited: 11Cited Reference Count: 18},
	month = {Dec},
	pages = {721-726},
	type = {Article},
	abstract = {A fungus isolated from the macroalga Fucus gardneri was identified by using 28S rDNA sequence analysis, 99\% similarity match, as Fusarium oxysporum meloni. The fungus was exposed to arsenic(V) (500 ppb) in artificial seawater to investigate the possibility that the fungus is the source of the metabolic activity that results in the presence of arsenosugars in the macroalga. High-performance liquid chromatography coupled with inductively coupled plasma mass spectrometry was used to identify the arsenic species in the fungus, and in the growth medium. The fungus was able to accumulate arsenic(V) and an increase in arsenite and dimethylarsinate was also observed. Some reduction of arsenate led to a small increase of arsenite in the growth medium. The fungus does not seem to be involved with the accumulation of arsenosugars by the Fucus. Copyright (C) 2002 John Wiley Sons, Ltd.},
	keywords = {(PCR), arsenic, BIOACCUMULATION, fungus, inductively coupled plasma, polymerase chain reaction, rDNA, SPECIATION},
	isbn = {0268-2605},
	url = {<Go to ISI>://000179655000006},
	author = {Granchinho, S. C. R. and Franz, C. M. and Polishchuk, E. and Cullen, W. R. and Reimer, K. J.}
}
@article {4916,
	title = {Cell-based screen for antimitotic agents and identification of analogues of rhizoxin, eleutherobin, and paclitaxel in natural extracts},
	journal = {Cancer Research},
	volume = {60},
	number = {18},
	year = {2000},
	note = {ISI Document Delivery No.: 358GQTimes Cited: 62Cited Reference Count: 55},
	month = {Sep},
	pages = {5052-5058},
	type = {Article},
	abstract = {We describe a cell-based assay for antimitotic compounds that is suitable for drug discovery and for quantitative determination of antimitotic activity, In the assay, cells arrested in mitosis as a result of exposure to antimitotic agents in pure form or in crude natural extracts are detected by ELISA using the monoclonal antibody TG-3, The assay was used to screen >24,000 extracts of marine microorganisms and invertebrates and terrestrial plants and to guide the purification of active compounds from 5 of 119 positive extracts. A new rhizoxin analogue was found in a Pseudomonas species, six new eleutherobin analogues were identified from the octocoral Erythropodium caribaeorum, and two paclitaxel analogues were found in the stem bark of the tree Ilex macrophylla. The assay was also used for quantitative comparison of the antimitotic activity of different analogues. It revealed the importance of the C-11 to C-13 segment of the diterpene core of eleutherobin for its antimitotic activity. The identification of antimitotic compounds in very low abundance and their high (0.5\%) occurrence in natural extracts indicates that drug discovery efforts using this cell-based assay may lead to the identification of structurally novel antimitotic agents.},
	keywords = {AGENT, ANTITUMOR, BINDING, fungus, INHIBITION, MACROCYCLIC LACTONE ANTIBIOTICS, MICROTUBULE-STABILIZING AGENTS, MITOTIC SPINDLES, RHIZOPUS-CHINENSIS, TAXOL, TUBULIN POLYMERIZATION},
	isbn = {0008-5472},
	url = {<Go to ISI>://000089550600013},
	author = {Roberge, M. and Cinel, B. and Anderson, H. J. and Lim, L. and Jiang, X. X. and Xu, L. and Bigg, C. M. and Kelly, M. T. and Andersen, R. J.}
}
