@article {2513,
	title = {Divalent later transition metal complexes of the traditional chinese medicine (TCM) liriodenine: coordination chemistry, cytotoxicity and DNA binding studies},
	journal = {Dalton Transactions},
	number = {48},
	year = {2009},
	note = {ISI Document Delivery No.: 527IETimes Cited: 1Cited Reference Count: 91Liu, Yan-Cheng Chen, Zhen-Feng Liu, Li-Min Peng, Yan Hong, Xue Yang, Bin Liu, Hua-Gang Liang, Hong Orvig, Chris},
	pages = {10813-10823},
	type = {Article},
	abstract = {Liriodenine (L), a natural alkaloid, was isolated as an active component from the anticancer traditional Chinese medicine (TCM), Zanthoxylum nitidum. It reacted with Mn-II, Fe-II, Co-II and Zn-II to afford four metal complexes: [MnCl2(L)(2)] (1), [FeCl2(L)(2)] (2), [Co(L)(2)(H2O)(2)center dot Co(L)(2)(CH3CH2OH)(2)](ClO4)(4) (3), and [Zn-2(L)(2)(mu(2)-Cl)(2)Cl-2] (4), which were characterized by elemental analysis, IR, ESI-MS. Their crystal structures were determined by the single crystal X-ray diffraction method. The in vitro cytotoxicity of L and complexes 1-4 against 10 human tumour cell lines was assayed. Some of these metal-based compounds exhibited enhanced cytotoxicity vs. free L to selected tumour cell lines. The binding properties of L and its complexes 1-4 to ct-DNA were investigated by spectroscopic methods and viscosity measurements. Agarose gel electrophoresis experiments were also carried out to evaluate their unwinding ability towards plasmid DNA and their inhibition towards Topoisomerase I. All the results indicate that complexes 1-4 may bind more intensively to the DNA helix than does L, and intercalative binding for complexes 1-4 and electrostatic interactions for complexes 3-4 to DNA should be considered. For complex 4, covalent binding to DNA may exist. Of special note, all these metal complexes effectively inhibit Topoisomerase I even at low concentration (<= 10 mu M).},
	keywords = {antitumor agents, CISPLATIN, CRYSTAL-STRUCTURE, GEL-ELECTROPHORESIS, INHIBITION, INNOVATIVE COMBINATION, INTERCALATION, PLATINUM ANTICANCER AGENTS, RUTHENIUM(II) COMPLEXES, TOPOISOMERASE-I},
	isbn = {1477-9226},
	url = {<Go to ISI>://000272359900023},
	author = {Liu, Y. C. and Chen, Z. F. and Liu, L. M. and Peng, Y. and Hong, X. and Yang, B. and Liu, H. G. and Liang, H. and Orvig, Chris}
}
@article {2388,
	title = {Potential new inorganic antitumour agents from combining the anticancer traditional Chinese medicine (TCM) liriodenine with metal ions, and DNA binding studies},
	journal = {Dalton Transactions},
	number = {2},
	year = {2009},
	note = {ISI Document Delivery No.: 385IHTimes Cited: 6Cited Reference Count: 68Chen, Zhen-Feng Liu, Yan-Cheng Liu, Li-Min Wang, Heng-Shan Qin, San-Hai Wang, Bo-Long Bian, He-Dong Yang, Bin Fun, Hoong-Kun Liu, Hua-Gang Liang, Hong Orvig, Chris},
	pages = {262-272},
	type = {Article},
	abstract = {Liriodenine (L), an active component of the anticancer traditional Chinese medicine (TCM), was isolated from Zanthoxylum nitidum. Its reactions with Pt(II) and Ru(II) afforded three metal complexes: cis-[PtCl2(L)] (1), cis-[PtCl2(L)(DMSO)] (2), and cis-[RuCl2(L)(DMSO)(2)]center dot 1.5H(2)O (3), the crystal structures of L, 2 and 3 were determined by single-crystal X-ray diffraction methods. These complexes were fully characterized by elemental analysis, IR spectrophotometry, H-1 and C-13 NMR spectroscopies, and ES mass spectrometry. The in vitro cytotoxicity of L and complexes 1-3 against 11 human tumour cell lines was assayed. The metal-based compounds exhibit enhanced cytotoxicity vs. free L, suggesting that these compounds display synergy in the combination of metal ions and liriodenine. The binding properties of L and its complexes 1-3 to ct-DNA were investigated through UV-vis, fluorescence, CD spectra, viscosity and agarose gels electrophoretic measurements.},
	keywords = {AFFINITY, ALKALOIDS, CISPLATIN, CYTOTOXIC ACTIVITY, DRUGS, FLUORESCENCE, IN-VITRO, PLATINUM(II) COMPLEXES, RUTHENIUM(II) COMPLEXES, TOPOISOMERASE-II},
	isbn = {1477-9226},
	url = {<Go to ISI>://000261807400006},
	author = {Chen, Z. F. and Liu, Y. C. and Liu, L. M. and Wang, H. S. and Qin, S. H. and Wang, B. L. and Bian, H. D. and Yang, B. and Fun, H. K. and Liu, H. G. and Liang, H. and Orvig, Chris}
}
@article {774,
	title = {Ruthenium(II) sulfoxide-maltolato and -nitroimidazole complexes: Synthesis and MTT assay},
	journal = {Inorganic Chemistry},
	volume = {42},
	number = {23},
	year = {2003},
	note = {ISI Document Delivery No.: 743FZTimes Cited: 14Cited Reference Count: 52},
	month = {Nov},
	pages = {7579-7586},
	type = {Article},
	abstract = {{Ru-II sulfoxide-maltolato complexes, Ru(ma)(2)(L)(2) (L = DMSO (1a) and TMSO (1b) or L-2 = BESE (1c)), were synthesized, as well as the analogous ethylmaltolato derivatives, Ru(etma)(2)(L)(2) (2a-c) (ma = 3-hydroxy-2-methylpyran-4-onate},
	keywords = {CISPLATIN, CRYSTAL-STRUCTURE, EXPERIMENTAL-TUMORS, IN-VITRO, MOLECULAR-STRUCTURE, NAMI-A, RADIOSENSITIZING ACTIVITY, RAY STRUCTURAL CHARACTERIZATION, SOLUTION CHEMISTRY, SULFOXIDE)RUTHENIUM(II)},
	isbn = {0020-1669},
	url = {<Go to ISI>://000186562900037},
	author = {Wu, A. and Kennedy, David C and Patrick, B. O. and James, Brian R.}
}
@article {5149,
	title = {Unprecedented sugar-dependent in vivo antitumor activity of carbohydrate-pendant cis-diamminedichloroplatinum(II) complexes},
	journal = {Bioorganic \& Medicinal Chemistry Letters},
	volume = {11},
	number = {23},
	year = {2001},
	note = {ISI Document Delivery No.: 494DZTimes Cited: 23Cited Reference Count: 15},
	month = {Dec},
	pages = {3045-3047},
	type = {Article},
	abstract = {Eight carbohydrate-pendant platinum(II) complexes have been synthesized from carbohydrate-diamine conjugates. D-Glucose, D-mannose, D-galactose, D-xylose, and L-glucose are attached to the dichloroplatinum(II) moiety by 1,3- or 1,2-diaminopropane chelates through with an O-glycoside bond. All the carbohydrate moieties reduced the toxicity inherent with platinum(II) complexes. (C) 2001 Elsevier Science Ltd. All rights reserved.},
	keywords = {CISPLATIN, DNA, DRUGS, MOLECULES},
	isbn = {0960-894X},
	url = {<Go to ISI>://000172267600013},
	author = {Mikata, Y. and Shinohara, Y. and Yoneda, K. and Nakamura, Y. and Brudzinska, I. and Tanase, T. and Kitayama, T. and Takagi, R. and Okamoto, T. and Kinoshita, I. and Doe, M. and Orvig, Chris and Yano, S.}
}
@article {4903,
	title = {Improved synthesis of isogranulatimide, a G2 checkpoint inhibitor. Syntheses of didemnimide C, isodidemnimide A, neodidemnimide A, 17-methylgranulatimide, and isogranulatimides A-C},
	journal = {Journal of Organic Chemistry},
	volume = {65},
	number = {2},
	year = {2000},
	note = {ISI Document Delivery No.: 276YFTimes Cited: 44Cited Reference Count: 35},
	month = {Jan},
	pages = {530-535},
	type = {Article},
	abstract = {A concise, improved synthesis of isogranulatimide (6), a naturally occurring substance with G2 checkpoint inhibition activity, is described. Also reported are the syntheses of didemnimide C (18), isodidemnimide A (24), neodidemnimide A (36), 17-methylgranulatimide (9), and isogranulatimides A (10), B (11), and C (12). Compounds 9-12, congeners of isogranulatimide (6), are now available for biological evaluation.},
	keywords = {BHK CELLS, CAFFEINE, CANCER, CELL-CYCLE CHECKPOINTS, CISPLATIN, DERIVATIVES, DNA-REPLICATION, ENHANCEMENT, IMIDAZOLES, RADIOSENSITIZATION},
	isbn = {0022-3263},
	url = {<Go to ISI>://000084905400039},
	author = {Piers, E. and Britton, R. and Andersen, R. J.}
}
