@article {1527, title = {A simple, catalytic H-2-hydrogenation method for the synthesis of fine chemicals; hydrogenation of protoporphyrin IX dimethyl ester}, journal = {Tetrahedron Letters}, volume = {47}, number = {29}, year = {2006}, note = {ISI Document Delivery No.: 058XJTimes Cited: 2Cited Reference Count: 61Reboucas, Julio S. James, Brian R.}, month = {Jul}, pages = {5119-5122}, type = {Article}, abstract = {A conceptually simple H-2-hydrogenation protocol is introduced for the high-yield preparation of a natural product derivative. Protoporphyrin IX dimethyl ester is hydrogenated to the mesoporphyrin analogue in N,N-dimethylacetamide under H-2 (1 atm) at 80 degrees C within 30 min. The reaction is catalyzed by commercial RUCl3, without the need for the use of phosphine- and/or carbene-based ligands. (c) 2006 Elsevier Ltd. All rights reserved.}, keywords = {ASYMMETRIC CATALYSIS, CARBON-MONOXIDE, COMPLEXES, HEME OXYGENASE-1, HORSERADISH-PEROXIDASE, MESOPORPHYRIN, METALLOPORPHYRINS, NUCLEAR-MAGNETIC-RESONANCE, PORPHYRIN, RUTHENIUM(II) MYOGLOBIN}, isbn = {0040-4039}, url = {://000238697600028}, author = {Reboucas, J. S. and James, Brian R.} }