@article {4434,
	title = {Ambewelamides A and B, antineoplastic epidithiapiperazinediones isolated from the lichen Usnea sp},
	journal = {Tetrahedron Letters},
	volume = {39},
	number = {52},
	year = {1998},
	note = {ISI Document Delivery No.: 148LLTimes Cited: 19Cited Reference Count: 15},
	month = {Dec},
	pages = {9579-9582},
	type = {Article},
	abstract = {Two potently cytotoxic epidithiapiperazinediones, ambewelamides A (1) and B (2), have been isolated from the lichen Usnea sp. collected in Sri Lanka. The structures were determined by a combination of X-ray crystallographic and spectroscopic analyses. (C) 1998 Elsevier Science Ltd. All rights reserved.},
	keywords = {microtubules, TAXOL},
	isbn = {0040-4039},
	url = {<Go to ISI>://000077506700001},
	author = {Williams, D. E. and Bombuwala, K. and Lobkovsky, E. and De Silva, E. D. and Karunaratne, V. and Allen, T. M. and Clardy, J. and Andersen, R. J.}
}
@article {3876,
	title = {Cytotoxic peptides hemiasterlin, hemiasterlin A and hemiasterlin B induce mitotic arrest and abnormal spindle formation},
	journal = {Cancer Chemotherapy and Pharmacology},
	volume = {39},
	number = {3},
	year = {1997},
	note = {ISI Document Delivery No.: VZ251Times Cited: 66Cited Reference Count: 17},
	month = {Jan},
	pages = {223-226},
	type = {Article},
	abstract = {Purpose: Hemiasterlin, hemiasterlin A and hemiasterlin B are newly isolated cytotoxic tripeptides with potential as antitumor drugs. We wished to determine their mechanism of cytotoxicity. Methods: We studied their effect on cell survival, cell cycle progression, and microtubule morphology in MCF-7 human mammary carcinoma cells. Results: At the nanomolar concentrations at which they were cytotoxic, the peptides induced arrest in mitotic metaphase. Hemiasterlin A produced abnormal mitotic spindles like those produced by the microtubule inhibitors taxol, nocodazole and vinblastine at low concentrations. At high concentrations hemiasterlin A did not cause microtubule bundling like taxol, but caused microtubule depolymerization like nocodazole and vinblastine. Conclusions: The hemiasterlins probably exert their cytotoxic effect by inhibiting spindle microtubule dynamics.},
	keywords = {CANCER, COLCHICINE SITE, FOSTRIECIN, INHIBITION, microtubules, mitosis, NATURAL-PRODUCTS, OKADAIC ACID, PHOSPHATASE-2A, PODOPHYLLOTOXIN, TAXOL, TUBULIN, VINBLASTINE, VINCA DOMAIN},
	isbn = {0344-5704},
	url = {<Go to ISI>://A1997VZ25100008},
	author = {Anderson, H. J. and Coleman, J. E. and Andersen, R. J. and Roberge, M.}
}
