@article {2513,
	title = {Divalent later transition metal complexes of the traditional chinese medicine (TCM) liriodenine: coordination chemistry, cytotoxicity and DNA binding studies},
	journal = {Dalton Transactions},
	number = {48},
	year = {2009},
	note = {ISI Document Delivery No.: 527IETimes Cited: 1Cited Reference Count: 91Liu, Yan-Cheng Chen, Zhen-Feng Liu, Li-Min Peng, Yan Hong, Xue Yang, Bin Liu, Hua-Gang Liang, Hong Orvig, Chris},
	pages = {10813-10823},
	type = {Article},
	abstract = {Liriodenine (L), a natural alkaloid, was isolated as an active component from the anticancer traditional Chinese medicine (TCM), Zanthoxylum nitidum. It reacted with Mn-II, Fe-II, Co-II and Zn-II to afford four metal complexes: [MnCl2(L)(2)] (1), [FeCl2(L)(2)] (2), [Co(L)(2)(H2O)(2)center dot Co(L)(2)(CH3CH2OH)(2)](ClO4)(4) (3), and [Zn-2(L)(2)(mu(2)-Cl)(2)Cl-2] (4), which were characterized by elemental analysis, IR, ESI-MS. Their crystal structures were determined by the single crystal X-ray diffraction method. The in vitro cytotoxicity of L and complexes 1-4 against 10 human tumour cell lines was assayed. Some of these metal-based compounds exhibited enhanced cytotoxicity vs. free L to selected tumour cell lines. The binding properties of L and its complexes 1-4 to ct-DNA were investigated by spectroscopic methods and viscosity measurements. Agarose gel electrophoresis experiments were also carried out to evaluate their unwinding ability towards plasmid DNA and their inhibition towards Topoisomerase I. All the results indicate that complexes 1-4 may bind more intensively to the DNA helix than does L, and intercalative binding for complexes 1-4 and electrostatic interactions for complexes 3-4 to DNA should be considered. For complex 4, covalent binding to DNA may exist. Of special note, all these metal complexes effectively inhibit Topoisomerase I even at low concentration (<= 10 mu M).},
	keywords = {antitumor agents, CISPLATIN, CRYSTAL-STRUCTURE, GEL-ELECTROPHORESIS, INHIBITION, INNOVATIVE COMBINATION, INTERCALATION, PLATINUM ANTICANCER AGENTS, RUTHENIUM(II) COMPLEXES, TOPOISOMERASE-I},
	isbn = {1477-9226},
	url = {<Go to ISI>://000272359900023},
	author = {Liu, Y. C. and Chen, Z. F. and Liu, L. M. and Peng, Y. and Hong, X. and Yang, B. and Liu, H. G. and Liang, H. and Orvig, Chris}
}
@article {2388,
	title = {Potential new inorganic antitumour agents from combining the anticancer traditional Chinese medicine (TCM) liriodenine with metal ions, and DNA binding studies},
	journal = {Dalton Transactions},
	number = {2},
	year = {2009},
	note = {ISI Document Delivery No.: 385IHTimes Cited: 6Cited Reference Count: 68Chen, Zhen-Feng Liu, Yan-Cheng Liu, Li-Min Wang, Heng-Shan Qin, San-Hai Wang, Bo-Long Bian, He-Dong Yang, Bin Fun, Hoong-Kun Liu, Hua-Gang Liang, Hong Orvig, Chris},
	pages = {262-272},
	type = {Article},
	abstract = {Liriodenine (L), an active component of the anticancer traditional Chinese medicine (TCM), was isolated from Zanthoxylum nitidum. Its reactions with Pt(II) and Ru(II) afforded three metal complexes: cis-[PtCl2(L)] (1), cis-[PtCl2(L)(DMSO)] (2), and cis-[RuCl2(L)(DMSO)(2)]center dot 1.5H(2)O (3), the crystal structures of L, 2 and 3 were determined by single-crystal X-ray diffraction methods. These complexes were fully characterized by elemental analysis, IR spectrophotometry, H-1 and C-13 NMR spectroscopies, and ES mass spectrometry. The in vitro cytotoxicity of L and complexes 1-3 against 11 human tumour cell lines was assayed. The metal-based compounds exhibit enhanced cytotoxicity vs. free L, suggesting that these compounds display synergy in the combination of metal ions and liriodenine. The binding properties of L and its complexes 1-3 to ct-DNA were investigated through UV-vis, fluorescence, CD spectra, viscosity and agarose gels electrophoretic measurements.},
	keywords = {AFFINITY, ALKALOIDS, CISPLATIN, CYTOTOXIC ACTIVITY, DRUGS, FLUORESCENCE, IN-VITRO, PLATINUM(II) COMPLEXES, RUTHENIUM(II) COMPLEXES, TOPOISOMERASE-II},
	isbn = {1477-9226},
	url = {<Go to ISI>://000261807400006},
	author = {Chen, Z. F. and Liu, Y. C. and Liu, L. M. and Wang, H. S. and Qin, S. H. and Wang, B. L. and Bian, H. D. and Yang, B. and Fun, H. K. and Liu, H. G. and Liang, H. and Orvig, Chris}
}
@article {5043,
	title = {A remarkable temperature-dependent, accidental degeneracy of P-31 NMR chemical shifts in Ru(II) diphosphine/diimine complexes},
	journal = {Chemical Communications},
	number = {17},
	year = {2001},
	note = {ISI Document Delivery No.: 469DQTimes Cited: 10Cited Reference Count: 26},
	month = {Sep},
	pages = {1570-1571},
	type = {Article},
	abstract = {Several cis-RUX2((R)-BINAP)(diimine) complexes have been prepared, and many of these exhibit an unusual temperature-dependent, accidental degeneracy of the P-31 shifts in their solution NMR spectra.},
	keywords = {ASYMMETRIC HYDROGENATION, BINAP, CATALYSIS, CHEMISTRY, DERIVATIVES, KETONES, LIGANDS, PHOSPHINE COMPLEXES, REACTIVITY, RUTHENIUM(II) COMPLEXES},
	isbn = {1359-7345},
	url = {<Go to ISI>://000170798800019},
	author = {Cyr, P. W. and Patrick, B. O. and James, Brian R.}
}
@article {4339,
	title = {The co-crystallization of Ru((R)-binap)(eta(3)-Me-allyl)(2) and binap dioxide, and synthesis of Ru(Ph2P(CH2)(4)PPh2)(eta(3)-Me-allyl)(2)},
	journal = {Journal of Organometallic Chemistry},
	volume = {557},
	number = {2},
	year = {1998},
	note = {ISI Document Delivery No.: ZQ872Times Cited: 8Cited Reference Count: 30},
	month = {Apr},
	pages = {213-219},
	type = {Article},
	abstract = {{The molecular structure of the 2-methylallyl species Ru((R)-binap)(eta(3)-Me-allyl)(2) (3) was established by X-ray crystallography of a crystal of 3a, the asymmetric unit of which is composed of half of a molecule of 3 and half of a (R)-(+)-2,2{\textquoteright}-bis(-diphenylphosphinoyl)-1,1{\textquoteright}-binaphthyl(binap dioxide) molecule, co-crystallized with two disordered deuterobenzenes; crystals of 3a are tetragonal, space group I422, with Z = 8},
	keywords = {allyl, ASYMMETRIC HYDROGENATION, BINAP, CATALYSTS, COMPLEXES, ENANTIOSELECTIVE HYDROGENATION, GENERAL-SYNTHESIS, KINETICS, rhodium, ruthenium, RUTHENIUM(II) COMPLEXES, X-ray crystal structure},
	isbn = {0022-328X},
	url = {<Go to ISI>://000073911500007},
	author = {Macfarlane, K. S. and Rettig, S. J. and Liu, Z. Q. and James, Brian R.}
}
@article {4387,
	title = {The reactivity of five-coordinate Ru(II)(1,4-bis(diphenylphosphino)butane) complexes with the N-donor ligands: ammonia, pyridine, 4-substituted pyridines, 2,2{\textquoteright}-bipyridine, bis(o-pyridyl)amine, 1,10-phenanthroline, 4,7-diphenylphenanthroline and ethylene},
	journal = {Inorganica Chimica Acta},
	volume = {267},
	number = {2},
	year = {1998},
	note = {ISI Document Delivery No.: YK955Times Cited: 48Cited Reference Count: 47},
	month = {Jan},
	pages = {209-221},
	type = {Article},
	abstract = {{A series of Ru(II) (1,4-bis(diphenylphosphino)butane) (L)(2) complexes was synthesized from [RuCl2(dppb)](2)(mu-dppb) or RuCl2(dppb)-(PPh3); dppb=Ph2P(CH2)(4)PPh2},
	keywords = {1, 4-BIS(DIPHENYLPHOSPHINO)BUTANE, amine-phosphine complexes, crystal structures, CRYSTAL-STRUCTURE, HYDROGENATION, IMINE, PHOSPHINE COMPLEXES, RUTHENIUM(II), RUTHENIUM(II) COMPLEXES, SOLID-STATE, X-RAY},
	isbn = {0020-1693},
	url = {<Go to ISI>://A1998YK95500005},
	author = {Queiroz, S. L. and Batista, A. A. and Oliva, G. and Gambardella, Mtdp and Santos, R. H. A. and Macfarlane, K. S. and Rettig, S. J. and James, Brian R.}
}
@article {4012,
	title = {Synthesis of chiral amines catalyzed homogeneously by metal complexes},
	journal = {Catalysis Today},
	volume = {37},
	number = {2},
	year = {1997},
	note = {ISI Document Delivery No.: XQ681Times Cited: 86Cited Reference Count: 73},
	month = {Aug},
	pages = {209-221},
	type = {Article},
	abstract = {This review describes developments in catalytic asymmetric hydrogenation of prochiral imines. The homogeneous systems were initially dominated by ones based on Rh complexes containing chiral, chelating diphosphine ligands, although related Ru-and Ir-based systems are becoming more prominent; a very recent, extremely effective hydrogen transfer system (from formic acid), based on Ru catalysts containing chiral 1,2-diamine ligands, is especially significant. A fundamentally different type involving an early transition-metal catalyst (a chiral titanocene) has been reported. Enantiomeric excess (e.e.) values in the range of 90-100\% have now been achieved with certain substrates. Emphasis is given to some Rh and Ru catalysts developed in the Department of Chemistry, The University of British Columbia (UBC). Factors discussed include: dependence of conversions, rates and e.e. values on substrate and catalyst type; kinetic dependences; and mechanistic insights, especially possible roles of intermediate metal-hydride and -imine species.},
	keywords = {ASYMMETRIC REDUCTIVE AMINATION, DIASTEREOSELECTIVE, HIGHLY ENANTIOSELECTIVE HYDROGENATION, HYDROGENATION, IMINE HYDROGENATION, KINETIC, PHOSPHINE COMPLEXES, RESOLUTION, rhodium, RUTHENIUM(II) COMPLEXES, SYSTEMS, TITANOCENE CATALYST},
	isbn = {0920-5861},
	url = {<Go to ISI>://A1997XQ68100009},
	author = {James, Brian R.}
}
@article {4123,
	title = {{Synthesis, structure, and reactivity of [RuCl(PP)L]PF6 (PP = (PPh3)(2), Ph2P(CH2)(4)PPh2; L = P(py)(3), PPh(py)(2)},
	journal = {Inorganic Chemistry},
	volume = {36},
	number = {25},
	year = {1997},
	note = {ISI Document Delivery No.: YK964Times Cited: 32Cited Reference Count: 43},
	month = {Dec},
	pages = {5809-5817},
	type = {Article},
	abstract = {{The complexes [RuCl(PPh3)(2)(P, N, N{\textquoteright}-PPh3-x(py)(x))]PF6 (x = 2, 1b; 3, 1c; py = 2-pyridyl) were isolated from the reaction of RuCl2(PPh3)(3) with 1 equiv of PPh3-x(py)(x) and NH4PF6 in acetone. Crystals of 1b (C52H43ClF6N2P4Ru) are monoclinic},
	keywords = {2-(DIPHENYLPHOSPHINO)PYRIDINE, BRIDGING LIGAND, COORDINATION, HYDROFORMYLATION, palladium complexes, PHOSPHINE COMPLEXES, rhodium, RUTHENIUM(II) COMPLEXES},
	isbn = {0020-1669},
	url = {<Go to ISI>://A1997YK96400025},
	author = {Schutte, R. P. and Rettig, S. J. and Joshi, A. M. and James, Brian R.}
}
@article {3392,
	title = {KINETICS AND MECHANISM OF H-2-HYDROGENATION OF STYRENE CATALYZED BY [RUCL(DPPB)(MU-CL)](2) (DPPB=1,4-BIS(DIPHENYLPHOSPHINO)BUTANE) - EVIDENCE FOR HYDROGEN-TRANSFER FROM A DINUCLEAR MOLECULAR-HYDROGEN SPECIES},
	journal = {Journal of Organometallic Chemistry},
	volume = {488},
	number = {1-2},
	year = {1995},
	note = {ISI Document Delivery No.: QG254Times Cited: 32Cited Reference Count: 31},
	month = {Feb},
	pages = {161-167},
	type = {Article},
	abstract = {Kinetic studies on the H-2-hydrogenation of styrene catalyzed by [RuCl(dppb)(mu-Cl)](2) (dppb = Ph(2)P(CH2)(4)PPh(2)) in N,N-dimethylacetamide solution, near ambient conditions have revealed a first-order dependence on Ru, and dependences on H-2 and on styrene that are first-order at lower concentrations and decrease with increasing concentration. Considered along with NMR and tensiometric data, the findings are interpreted in terms of a basic hydride route in which an initially formed, dinuclear, molecular hydrogen complex (eta(2)-H-2)Ru(dppb)(mu-Cl)(3)RuCl(dppb) transfers both hydrogens to the styrene.},
	keywords = {ASYMMETRIC HYDROGENATION, BINAP, CATALYSIS, COMPLEXES, DIHYDROGEN, dihydrogen complexes, HYDROGENATION, KINETICS, LIGANDS, phosphine, ruthenium, RUTHENIUM(II) COMPLEXES, SELECTIVE, STYRENE, UNSATURATED CARBOXYLIC-ACIDS},
	isbn = {0022-328X},
	url = {<Go to ISI>://A1995QG25400022},
	author = {Joshi, A. M. and Macfarlane, K. S. and James, Brian R.}
}
@article {7272,
	title = {SYNTHESIS, CHARACTERIZATION AND REACTIVITY OF SOME MONONUCLEAR AND DINUCLEAR CHLORORUTHENIUM COMPLEXES CONTAINING CHELATING DITERTIARY PHOSPHINES (P-P) WITH P-PRU = 1},
	journal = {Inorganica Chimica Acta},
	volume = {198},
	year = {1992},
	note = {ISI Document Delivery No.: JK243Times Cited: 72Cited Reference Count: 92},
	month = {Aug-Oct},
	pages = {283-296},
	type = {Article},
	abstract = {{Mixed-valence complexes of the type (P-P)ClRu(mu-Cl)3RuCl(P-P), and the [RuCl(P-P)]2(mu-Cl)2 products formed by their reduction with H2, are synthesized, where P-P is a chelating ditertiary phosphine Ph2P(CH2)nPPh2 (n = 3-6) or some related chiral analogues such as diop, chiraphos, dppcp, dpcycp, bdpp, binap, phenop or norphos (diop = Ph2PCH2CHOCMe2OCHCH2PPh2; chiraphos = Ph2PCH(Me)CH(Me)PPh2; dppcp = Ph2PCH(CH2)3CHPPh2; dpcycp = (C6H11)2PCH(CH2)3CHP(C6H11)2; bdpp(skewphos) = Ph2PCH(Me)CH2CH(Me)PPh2; binap = 2,2{\textquoteright}-bis(diphenylphosphine)-1,1{\textquoteright}-binaphthyl; phenop = Ph2PN(Et)CH(CH2Ph)CH2OPPh2; norphos = Ph2PCHCHCH=CHCH(CH2)CHPPh2). The [RuCl(binap)]2(mu-Cl)2 species is also formed in solution by dissociation of PPh3 from RuCl2(binap)(PPh3) which is synthesized by phosphine exchange with RuCl2(PPh3)3. From the [RuCl(P-P)]2(mu-Cl)2 complex (P-P = Ph2P(CH2)4PPh2), a range of L(P-P)Ru(mu-Cl)3RuCl(P-P) species is readily formed, where L includes an amine, acetone, NN-dimethylacetamide, Mel, PhCN, CO, N2 or H2; the L = NEt3 adduct is made also from RUCl2(dppb)(PPh3), while the corresponding dimethyl sulfoxide adduct (L = DMSO), 17e, is synthesized directly from cis-RuCl2(DMSO)4 and the phosphine. P-31{H-1} NMR data are presented for the Ru(II) species, while characterization of 17e includes an X-ray_crystallographic analysis that confirms the trichloro-bridged formulation. Crystal data are as follows: triclinic, P1BAR},
	keywords = {1{\textquoteright}-BINAPHTHYL, 2, 2{\textquoteright}-BIS(DIPHENYLPHOSPHINO)-1, ASYMMETRIC HYDROGENATION, BINAP-RUTHENIUM(II) COMPLEXES, CATALYSTS, COMPLEXES, CRYSTAL-STRUCTURE, DICARBOXYLATE, MECHANISM, ROUTE, RUTHENIUM(II) COMPLEXES, UNSATURATED CARBOXYLIC-ACIDS},
	isbn = {0020-1693},
	url = {<Go to ISI>://A1992JK24300031},
	author = {Joshi, A. M. and Thorburn, I. S. and Rettig, S. J. and James, Brian R.}
}
