@article {477,
	title = {Chiral separation of benzoporphyrin derivative mono- and diacids by laser induced fluorescence-capillary electrophoresis},
	journal = {Electrophoresis},
	volume = {23},
	number = {1},
	year = {2002},
	note = {ISI Document Delivery No.: 513ZATimes Cited: 9Cited Reference Count: 42},
	month = {Jan},
	pages = {93-101},
	type = {Article},
	abstract = {A method for the separation of benzoporphyrin derivative mono- and diacid (BPDMA, BPDDA) enantiomers; by laser induced fluorescence-capillary electrophoresis (LIF-CE) has been developed. By using 300 mm borate buffer, pH 9.2, 25 mm sodium cholate and 10\% acetronitrile as electrolyte, +10 kV electrokinetic sampling injection of 2 s and an applied +20 kV voltage across the ends of a 37 cm capillary (30 cm to the detector, 50 mum ID), all six BPD stereoisomers; were baseline-separated within 20 min. Formation constants, free electrophoretic and complexation mobilities with borate and cholate were determined based on dynamic complexation capillary electrophoresis theory. The BPD enantiomers can be quantitatively determined in the range of 10(-2)-10(-5) mg mL(-1). The correlation coefficients (r(2)) of the least-squares linear regression analysis of the BPD enantiomers are in the range of 0.9914-0.9997. Their limits of detection are 2.18-3.5 x 10(-3) mg mL(-1). The relative standard deviations for the separation were 2.90-4.64\% (n = 10). In comparison with high-performance liquid chromatography (HPLC), CE has better resolution and efficiency. This separation method was successfully applied to the BPD enantiomers obtained from a matrix of bovine serum and from liposomally formulated material as well as from studies with rat, dog and human microsomes.},
	keywords = {benzoporphyrin derivative mono- and diacids, BORATE COMPLEXATION, capillary electrophoresis, DYNAMIC COMPLEXATION MODEL, MIGRATION BEHAVIOR, PERFORMANCE LIQUID-CHROMATOGRAPHY, PHOTODYNAMIC THERAPY, PHOTOSENSITIZER, porphyrins, QUANTITATIVE DESCRIPTION, SYSTEM, TUMOR, ZONE ELECTROPHORESIS},
	isbn = {0173-0835},
	url = {<Go to ISI>://000173410100014},
	author = {Peng, X. J. and Sternberg, E. and Dolphin, D.}
}
@article {2971,
	title = {MESO-PHENYL SUBSTITUTED PORPHOCYANINES - A NEW CLASS OF FUNCTIONALIZED EXPANDED PORPHYRINS},
	journal = {Tetrahedron Letters},
	volume = {35},
	number = {30},
	year = {1994},
	note = {ISI Document Delivery No.: NY923Times Cited: 18Cited Reference Count: 11},
	month = {Jul},
	pages = {5377-5380},
	type = {Article},
	abstract = {Porphocyanines bearing phenyl substituents at both or one of the two available mesopositions have been synthesised. Derivatives have also been synthesised with substituents on the phenyl rings and both alkyl and unsubstituted pyrrolic beta-positions.},
	keywords = {BIOLOGICAL-ACTIVITIES, EXPANDED PORPHYRINS, INVITRO, PHOTODYNAMIC THERAPY, PHOTOTOXICITY, PORPHOCYANINES, TUMOR, ZINC PHTHALOCYANINES},
	isbn = {0040-4039},
	url = {<Go to ISI>://A1994NY92300015},
	author = {Boyle, R. W. and Xie, L. Y. and Dolphin, D.}
}
@article {7365,
	title = {INVITRO SCREENING OF CRUDE EXTRACTS AND PURE METABOLITES OBTAINED FROM MARINE-INVERTEBRATES FOR THE TREATMENT OF BREAST-CANCER},
	journal = {Cancer Chemotherapy and Pharmacology},
	volume = {30},
	number = {5},
	year = {1992},
	note = {ISI Document Delivery No.: JG989Times Cited: 31Cited Reference Count: 27},
	month = {Sep},
	pages = {401-406},
	type = {Article},
	abstract = {A total of 15 samples (crude extracts and pure secondary metabolites) obtained from marine invertebrates collected from the offshore waters of British Columbia, Papua New Guinea, and Sri Lanka have previously been shown to exert cytotoxic activity in the in vitro L1210 leukemic bioassay. We screened these metabolites for in vitro cytotoxic activity against the drug-sensitive breast-tumor cell lines MCF-7, T-47D, ZR-75- 1, and MDA-MB23 1; the multidrug-resistant and P-glycoprotein (Pgp)-positive breast-tumor cell lines MCF-7 Ad(r) and MDA-Al(r); and normal and malignant human breast epithelial cells (HBEC) in primary culture. Eight samples exhibited significant [drug concentration resulting in a 50\% decrease in cell growth as compared with controls (ED50), <25-mu-g/ml] dose-dependent cytotoxicity against the drug-sensitive cell lines; the ED50 values were as low as 0.004-mu-g/ml. Five of the eight samples exhibited significant cytotoxicity against the multidrug-resistant cell lines; the ED50 values were as low as 0.0006-mu-g/ml. Incubation of MCF-7 Ad(r) cells with varying concentrations of compounds in the presence of Adriamycin demonstrated that none of the compounds tested interfered with Pgp function. Results obtained using HBEC in primary culture showed a wide range of chemosensitivities for a given drug against tissue taken from different patients, demonstrating the uniqueness of the response of different individuals to chemotherapy.},
	keywords = {BREAST CANCER, CELLS, chemotherapy, COLORIMETRIC ASSAY, GROWTH, INVITRO SCREENING, MARINE ORGANISMS, SPONGE, TUMOR},
	isbn = {0344-5704},
	url = {<Go to ISI>://A1992JG98900011},
	author = {Stingl, J. and Andersen, R. J. and Emerman, J. T.}
}
