@article {2491, title = {The Direct Synthesis of Unsymmetrical Vicinal Diamines from Terminal Alkynes: A Tandem Sequential Approach for the Synthesis of Imidazolidinones}, journal = {Synthesis-Stuttgart}, number = {1}, year = {2009}, note = {ISI Document Delivery No.: 395LSTimes Cited: 6Cited Reference Count: 84Lee, Alison V. Sajitz, Melanie Schafer, Laurel L.Sp. Iss. SI}, month = {Jan}, pages = {97-104}, type = {Article}, abstract = {The combination of titanium-catalyzed anti-Markovnikov hydroamination of terminal alkynes with the Strecker reaction is used in the synthesis of unsymmetrical vicinal diamines via the one-pot synthesis of alpha-cyanoamines. This methodology is Further applied to the efficient synthesis of imidazolidinones. An easy-to-use bis(amidate)titanium precatalyst permits efficient approaches to heterocyclic chemistry from terminal alkynes.}, keywords = {AMINES, ANTI-MARKOVNIKOV, ASYMMETRIC-SYNTHESIS, CATALYZED INTERMOLECULAR HYDROAMINATION, HETEROCYCLES, HYDROAMINATION, IMIDO COMPLEXES, INTRAMOLECULAR HYDROAMINATION, LIGANDS, SCOPE, tandem reactions, TITANIUM, TITANIUM PRECATALYST, VINYLARENES}, isbn = {0039-7881}, url = {://000262526200012}, author = {Lee, A. V. and Sajitz, M. and Schafer, L. L.} } @article {1060, title = {Intramolecular hydroamination of unactived olefins with Ti(NMe2)(4) as a precatalyst}, journal = {Organic Letters}, volume = {7}, number = {10}, year = {2005}, note = {ISI Document Delivery No.: 924NCTimes Cited: 104Cited Reference Count: 59}, month = {May}, pages = {1959-1962}, type = {Article}, abstract = {[GRAPHICS] Commercially available Ti(NMe2)(4) has been used effectively as a precatalyst in a facile protocol for the intramolecular hydroamination of aminoalkenes to yield pyrrolidine and piperidine heterocyclic products with isolated yields up to 92\%. Germinally substituted substrates display the highest reactivity. This precatalyst is also effective for the hydroamination of activated internal alkenes, providing access to more complex heterocyclic target molecules.}, keywords = {ALKENE HYDROAMINATION, ALKYNE, AMIDO COMPLEXES, ANTI-MARKOVNIKOV, CATALYZED INTERMOLECULAR HYDROAMINATION, GROUP-3 METALS, HYDROAMINATION, IMIDO COMPLEXES, REACTIVITY, TITANIUM, ZIRCONIUM}, isbn = {1523-7060}, url = {://000228984500019}, author = {Bexrud, J. A. and Beard, J. D. and Leitch, D. C. and Schafer, L. L.} }