@article {LU2019111567,
	title = {Discovery of β-carboline copper(II) complexes as Mcl-1 inhibitor and in~vitro and in~vivo activity in cancer models},
	journal = {Eur. J. Med Chem.},
	volume = {181},
	year = {2019},
	pages = {111567},
	abstract = {<p>Mcl-1 is an anti-apoptotic member of Bcl-2 family proteins. The development of inhibitors of Mcl-1 has been challenging. To develop metal-based Mcl-1inhibitors, twenty two copper(II) complexes 25\&ndash;46 with 9-substituted β-carboline derivatives were reported. Complexes 38 and 39 showed higher cytotoxicity than the corresponding ligands or cisplatin. The most potent complex 39 presented higher selectivity to Mcl-1 than other Bcl-2 family proteins, and killed cancer cells via Bax/Bak mediated apoptosis. Complex 39 showed an excellent safety profile in mouse model, and significantly inhibited the tumor growth in NCI-H460 tumor bearing model, which is more potent than AZD5991 at the same dosage. Complex 39 prolonged the survival time of the tumor bearing mice. Complex 39 is the first metal-based Mcl-1 inhibitor acting as a potential anticancer agent.</p>},
	keywords = {ANTICANCER, apoptosis, COPPER(II) COMPLEX, Mcl-1, β-Carboline},
	issn = {0223-5234},
	doi = {https://doi.org/10.1016/j.ejmech.2019.111567},
	url = {http://www.sciencedirect.com/science/article/pii/S022352341930697X},
	author = {Xing Lu and Yan-Cheng Liu and Chris Orvig and Hong Liang and Zhen-Feng Chen}
}
@article {3949,
	title = {Synthesis and characterization of the mixed valence Cu(I)/Cu(II) 3,5-bis(trifluoromethyl)-pyrazolate complex, [Cu(II)(2)Cu(I)(F(6)dmpz)(5)]},
	journal = {Canadian Journal of Chemistry-Revue Canadienne De Chimie},
	volume = {75},
	number = {5},
	year = {1997},
	note = {ISI Document Delivery No.: XF492Times Cited: 18Cited Reference Count: 17},
	month = {May},
	pages = {491-498},
	type = {Article},
	abstract = {{The reaction of molten 3,5-bis(trifluoromethyl)pyrazole (F(6)dmpzH) with copper metal shot under an atmosphere of dioxygen yields the green trimetallic mixed valence [Cu(II)(2)Cu(I)(F(6)dmpz)(5)]. Crystals of [Cu(II)(2)Cu(I)F(6)dmpz)(5)] are triclinic},
	keywords = {3, 5-bis(trifluoromethyl)pyrazolates, ANTIFERROMAGNETISM, copper, COPPER(II) COMPLEX, MAGNETIC-PROPERTIES, METAL PYRAZOLATE POLYMERS, RAY CRYSTAL-STRUCTURE, STRUCTURE, trimetallic, X-RAY},
	isbn = {0008-4042},
	url = {<Go to ISI>://A1997XF49200003},
	author = {Ehlert, M. K. and Storr, A. and Summers, D. A. and Thompson, R. C.}
}
@article {3949,
	title = {Synthesis and characterization of the mixed valence Cu(I)/Cu(II) 3,5-bis(trifluoromethyl)-pyrazolate complex, [Cu(II)(2)Cu(I)(F(6)dmpz)(5)]},
	journal = {Canadian Journal of Chemistry-Revue Canadienne De Chimie},
	volume = {75},
	number = {5},
	year = {1997},
	note = {ISI Document Delivery No.: XF492Times Cited: 18Cited Reference Count: 17},
	month = {May},
	pages = {491-498},
	type = {Article},
	abstract = {{The reaction of molten 3,5-bis(trifluoromethyl)pyrazole (F(6)dmpzH) with copper metal shot under an atmosphere of dioxygen yields the green trimetallic mixed valence [Cu(II)(2)Cu(I)(F(6)dmpz)(5)]. Crystals of [Cu(II)(2)Cu(I)F(6)dmpz)(5)] are triclinic},
	keywords = {3, 5-bis(trifluoromethyl)pyrazolates, ANTIFERROMAGNETISM, copper, COPPER(II) COMPLEX, MAGNETIC-PROPERTIES, METAL PYRAZOLATE POLYMERS, RAY CRYSTAL-STRUCTURE, STRUCTURE, trimetallic, X-RAY},
	isbn = {0008-4042},
	url = {<Go to ISI>://A1997XF49200003},
	author = {Ehlert, M. K. and Storr, A. and Summers, D. A. and Thompson, R. C.}
}
