| Title | Capturing aqueous [F-18]-fluoride with an arylboronic ester for PET: Synthesis and aqueous stability of a fluorescent [F-18]-labeled aryltrifluoroborate |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Ting, R, Lo, J, Adam, MJ, Ruth, TJ, Perrin, DM |
| Journal | Journal of Fluorine Chemistry |
| Volume | 129 |
| Pagination | 349-358 |
| Date Published | May |
| Type of Article | Article |
| ISBN Number | 0022-1139 |
| Keywords | ACIDS, aryltrifluoroborate, CROSS-COUPLING REACTIONS, KINETICS, PET, SYNTHESIS, [F-18]-labeling |
| Abstract | The aqueous stability of aryltrifluoroborates is of importance to their use in transition metal mediated coupling reactions as well as their potential use in [F-18]-labeled aryltrifluoroborate PET imaging agents. Nevertheless, few studies have fully characterized the solvolysis of fluoride from an aryltrifluoroborate in water. Using [F-19] NMR, fluorescence and [F-18]-labeling techniques, we disclose the composition of an aryltrifluoroborate of exceptional kinetic stability with respect to solvolytic defluoridation. This work not only highlights the potential of using [F-18]-labeled aryltrifluoroborates for PET tracers, but provides a chemical platform and a general approach for evaluating the stability of other aryltrifluoroborates. (c) 2008 Elsevier B.V. All rights reserved. |
| URL | <Go to ISI>://000255990600005 |
