|Title||Dentigerumycin F and G: Dynamic structures retrieved through a genome-mining/nitrogen-NMR methodology|
|Publication Type||Journal Article|
|Year of Publication||2022|
|Authors||Morgan, KD, Williams, DE, Ryan, KS, Andersen, RJ|
|Keywords||Genome mining, Natural product discovery, Nitrogen-15, NMR-guided discovery, Piperazic acid|
Continual efforts to unearth new natural product chemistry expands our understanding of the scope of chemical space. Here we report the two low-abundance piperazic acid-containing linear peptides dentigerumycins F (1) and G (2), discovered through a combined genome-mining/15N NMR-based discovery method. Dentigerumycins F and G demonstrate a dynamic equilibrium in their oxane ring systems, which complicated structure elucidation. The application of various NMR solvents and conditions revealed the constitution of these natural products.