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Oxaziridine cleavage with a low-valent nickel complex: competing C-O and C-N fragmentation from oxazanickela(II)cyclobutanes

TitleOxaziridine cleavage with a low-valent nickel complex: competing C-O and C-N fragmentation from oxazanickela(II)cyclobutanes
Publication TypeJournal Article
Year of Publication2017
AuthorsDesnoyer, AN, Chiu, W, Cheung, C, Patrick, BO, Love, JA
JournalCHEMICAL COMMUNICATIONS
Volume53
Pagination12442-12445
Date PublishedNOV 28
ISSN1359-7345
Abstract

Reacting the low-valent nickel complex {[}(dtbpe)Ni](2)(mu-eta(2): eta(2)-C6H6) with oxaziridines was found to form mixtures of imine, amide and aldehyde products. If the N-substituent of the oxaziridine is sufficiently bulky, a short-lived intermediate can be isolated and characterized by X-ray diffraction studies as an oxazanickela(II) cyclobutane. This is the first well-defined example of N-O oxidative addition of an oxaziridine to a transition metal. Subsequent fragmentation of this oxazanickelacyclobutane forms a complex mixture of products, including a nickel(II) imido complex, demonstrating that oxaziridines can serve as nitrene precursors. Preliminary mechanistic analysis is consistent with a bimetallic mechanism of fragmentation of the oxazanickelacyclobutane to form the nickel imido and eta(2)-aldehyde complexes.

DOI10.1039/c7cc07690h