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Separation of 44Ti from proton irradiated scandium by using solid-phase extraction chromatography and design of 44Ti/44Sc generator system

TitleSeparation of 44Ti from proton irradiated scandium by using solid-phase extraction chromatography and design of 44Ti/44Sc generator system
Publication TypeJournal Article
Year of Publication2016
AuthorsRadchenko, V, Meyer, CAL, Engle, JW, Naranjo, CM, Unc, GA, Mastren, T, Brugh, M, Birnbaum, ER, John, KD, Nortier, FM, Fassbender, ME
JournalJournal of Chromatography A
Volume1477
Pagination39 - 46
ISSN0021-9673
KeywordsBDGA, Sc, Scandium metal target, Solid phase extraction chromatography, Ti, ZR resin
Abstract

Scandium-44g (half-life 3.97h [1]) shows promise for positron emission tomography (PET) imaging of longer biological processes than that of the current gold standard, 18F, due to its favorable decay parameters. One source of 44gSc is the long-lived parent nuclide 44Ti (half-life 60.0 a). A 44Ti/44gSc generator would have the ability to provide radionuclidically pure 44gSc on a daily basis. The production of 44Ti via the 45Sc(p,2n) reaction requires high proton beam currents and long irradiation times. Recovery and purification of no-carrier added (nca) 44Ti from scandium metal targets involves complex separation chemistry. In this study, separation systems based on solid phase extraction chromatography were investigated, including branched diglycolamide (BDGA) resin and hydroxamate based ZR resin. Results indicate that ZR resin in HCl media represents an effective 44Ti/44gSc separation system.

URLhttp://www.sciencedirect.com/science/article/pii/S0021967316315795
DOI10.1016/j.chroma.2016.11.047