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THE USE OF LIPOSOMES IN PREDICTING THE BIOLOGICAL MOBILITY OF ARSENIC COMPOUNDS

TitleTHE USE OF LIPOSOMES IN PREDICTING THE BIOLOGICAL MOBILITY OF ARSENIC COMPOUNDS
Publication TypeJournal Article
Year of Publication1992
AuthorsCullen, WR, Nelson, J
JournalApplied Organometallic Chemistry
Volume6
Pagination179-183
Date PublishedApr
Type of ArticleProceedings Paper
ISBN Number0268-2605
KeywordsDIFFUSION, LIPOSOMES, MEMBRANE, ORGANOARSENIC
Abstract

Efflux studies of radio-labelled methylarsonic acid (MMA) and dimethylarsinic acid (DMA) encapsulated in liposomes afford the following permeability values for the two arsenicals: 1.4 x 10(-13) cm s-1 and 4.5 x 10(-11) cm s-1 for MMA and DMA, respectively. These data are compared with the octanol/water partition coefficients which are 7.4 x 10(-3) and 8.4 x 10(-3) for MMA and DMA, respectively.

URL<Go to ISI>://A1992HQ16800010