Intermolecular Misfolding Captured in Parallelly Organized Titin
The Li Group's exciting discovery reveals that when titin Ig domains are arranged in parallel, just like their organization within muscle sarcomeres, they can misfold into a stable intermolecular domain-swapped state, which is both thermally and mechanically stable—offering new insights into how this unique misfolding could play an important role in the structure and elasticity of muscle.
Congratulations to PhD student Katrina Bergmann from the Hudson group who has been awarded the 2024 Science Excellence in Service Award in the student category! This award recognizes staff,...