Interrogating the thionium hydrogen bond as a noncovalent stereocontrolling interaction in chiral phosphate catalysis

CH⋯O bonds are a privileged noncovalent interaction determining the energies and geometries of a large number of structures. In catalytic settings, these are invoked as a decisive feature controlling many asymmetric transformations involving aldehydes. However, little is known about their stereochemical role when the interaction involves other substrate types. We report the results of computations that show for the first time thionium hydrogen bonds to be an important noncovalent interaction in asymmetric catalysis. As a validating case study, we explored an asymmetric Pummerer...


Mar 23 2023 - 10:00am to 11:30am
Dr. Emmanuel Castillo
NuChem Sciences
Mar 28 2023 - 12:45pm to 2:00pm
Dr. Xuanhe Zhao
Department of Mechanical Engineering, Massachusetts Institute of Technology
Mar 29 2023 - 5:00pm to 6:00pm
Tian Zhang
University of British Columbia


Chemistry Alum Gets a Positive Reaction to Debut Novel

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Women in Science: Katrina Bergmann

Katrina Bergmann is a second-year PhD student in the Department of Chemistry at the University of British Columbia, where she conducts research at the interface of computational, physical, and materials chemistry. Katrina is a...