Interrogating the thionium hydrogen bond as a noncovalent stereocontrolling interaction in chiral phosphate catalysis

CH⋯O bonds are a privileged noncovalent interaction determining the energies and geometries of a large number of structures. In catalytic settings, these are invoked as a decisive feature controlling many asymmetric transformations involving aldehydes. However, little is known about their stereochemical role when the interaction involves other substrate types. We report the results of computations that show for the first time thionium hydrogen bonds to be an important noncovalent interaction in asymmetric catalysis. As a validating case study, we explored an asymmetric Pummerer...


Nov 29 2022 - 12:45pm to 2:00pm
Dr. Mark Lautens | CGSS Distinguished Lecture
Department of Chemistry, University of Toronto


Congratulations Sarah Burke

Congratulations to Dr. Sarah Burke for being awarded the 2022 Killam Mentoring Award!

Dr. Burke has been awarded for providing constant opportunities to hone essential skills in areas such as critical thinking, public speaking, and grant...

Congratulations to Parisa Mehrkhodavandi!

Congratulations to Professor Parisa Mehrkhodavandi for being awarded the Wall Fellow award!

As part of being a Wall Scholar, Dr. Mehrkhodavandi will work with colleagues in disparate fields to try to understand the impacts of changing our...