Research

Patterned Signal Ratio Biases in Mass Spectrometry-Based Quantitative Metabolomics

Despite the well-known nonlinear response of electrospray ionization (ESI) in mass spectrometry (MS)-based analysis, its complicated response patterns and negative impact on quantitative comparison are still understudied. We showcase in this work that the patterns of nonlinear ESI response are feature-dependent and can cause significant compression or inflation to signal ratios. In particular, our metabolomics study of serial diluted human urine samples showed that over 72% and 16% metabolic features suffered ratio compression and inflation, respectively, whereas only 12% of the signal...

Events

Jan 19 2021 - 12:45pm to 2:00pm
Gerry Wright | Laird
Department of Biochemistry and Biomedical Sciences, McMaster University
Jan 20 2021 - 5:00pm to 6:00pm
Yitao Xu
University of British Colombia
Jan 21 2021 - 12:45pm to 2:00pm
Prof. Ran Zhao
University of Alberta

News

Congratulations to Sabrina Fried!

Congratulations to Sabrina Fried for the 2020 Science Excellence in Service Award. This award recognizes the exceptional service contributions of Science’s staff, students and faculty. The winners will be honoured at the upcoming Faculty of...

Congratulations to Greg Dake!

Congratulations to Dr. Greg Dake for the 2020 Science Excellence in Service Award. This award recognizes the exceptional service contributions of Science’s staff, students and faculty. The winners will be honoured at the upcoming Faculty of...