| Title | 1-Deoxygalactonojirimycin-lysine hybrids as potent D-galactosidase inhibitors |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Steiner, AJ, Schitter, G, Stuetz, AE, Wrodnigg, TM, Tarling, CA, Withers, SG, Fantur, K, Mahuran, D, Paschke, E, Tropak, M |
| Journal | BIOORGANIC & MEDICINAL CHEMISTRY |
| Volume | 16 |
| Pagination | 10216-10220 |
| Date Published | DEC 15 |
| ISSN | 0968-0896 |
| Abstract | Cyclization by double reductive amination of L-arabino-hexos-5-ulose with suitably protected D- as well as L-lysine derivatives provided 1-deoxygalactonojirimycin lysine hybrids without any observable epimer formation at C-5. Modi. cations on the lysine moiety by acylation gave access to lipophilic derivatives which exhibited excellent D-galactosidase inhibitory activities. (C) 2008 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.bmc.2008.10.054 |
