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(55)Cobalt complexes with pendant carbohydrates as potential PET imaging agents

Title(55)Cobalt complexes with pendant carbohydrates as potential PET imaging agents
Publication TypeJournal Article
Year of Publication2007
AuthorsFerreira, CL, Lapi, S, Steele, J, Green, DE, Ruth, TJ, Adam, MJ, Orvig, C
JournalApplied Radiation and Isotopes
Volume65
Pagination1303-1308
Date PublishedDec
ISBN Number0969-8043
Abstract

Bis-ligand cobalt(II) complexes of four 3-hydroxy-4-pyridinone ligands with pendant carbohydrates were synthesized and examined for their potential as radiopharmaceuticals. Non-radioactive complexes were prepared on the macroscopic scale and characterized by elemental analysis, mass spectrometry, IR and UV/visible spectroscopy. Facile radiolabeling produced the (CO)-C-55 complexes in high radiochemical yields (> 95%). Identification of the radiolabeled compounds was accomplished by HPLC comparison with the corresponding non-radioactive complexes. (c) 2007 Elsevier Ltd. All rights reserved.

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