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Alotaketals A and B, Sesterterpenoids from the Marine Sponge Hamigera Species that Activate the cAMP Cell Signaling Pathway

TitleAlotaketals A and B, Sesterterpenoids from the Marine Sponge Hamigera Species that Activate the cAMP Cell Signaling Pathway
Publication TypeJournal Article
Year of Publication2009
AuthorsForestier, R, Merchant, CE, de Voogd, NJ, Matainaho, T, Kieffer, TJ, Andersen, RJ
JournalOrganic Letters
Volume11
Pagination5166-5169
Date PublishedNov
Type of ArticleArticle
ISBN Number1523-7060
KeywordsCHEMICAL GENETICS, FORSKOLIN
Abstract

The new sesterterpenoids alotaketals A (1) and B (2) have been isolated from extracts of the marine sponge Hamigera sp. collected in Papua New Guinea. Their chemical structures were elucidated by analysis of spectroscopic data. Alotaketals A and B have the unprecedented alotane carbon skeleton, and they activate the cAMP cell signaling pathway with EC50’s of 18 and 240 nM, respectively.
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