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Altering pyridinone N-substituents to optimise activity as potential prodrugs for Alzheimer’s disease

TitleAltering pyridinone N-substituents to optimise activity as potential prodrugs for Alzheimer’s disease
Publication TypeJournal Article
Year of Publication2008
AuthorsScott, LE, Page, BDG, Patrick, BO, Orvig, C
JournalDalton Transactions
Pagination6364-6367
Type of ArticleArticle
ISBN Number1477-9226
Keywordsaluminum, BLOOD-BRAIN-BARRIER, COMPLEXES, DISORDERS, DIVALENT, IRON CHELATORS, PENETRATION, STABILITIES, therapy, TRIVALENT METAL-IONS
Abstract

Selective design modifications of specifically substituted 3-hydroxy-4(1H)-pyridinones show possibly advantageous ring freedom while maintaining metal-binding ability and antioxidant capacity, moving toward an efficient potential treatment for Alzheimer’s disease.

URL<Go to ISI>://000260834600005